Multicomponent Nanocomposites for Complex Anticancer Therapy: Effect of Aggregation Processes on Their Efficacy
Multicomponent nanocomposites for anticancer therapy were prepared, characterized, and tested for their antitumor efficacy. The water-soluble star-like dextran-graft-polyacrylamide copolymer was used as a nanoplatform for the creation of polymer-based multicomponent drug delivery systems for photody...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2020-01-01
|
| Series: | International Journal of Polymer Science |
| Online Access: | http://dx.doi.org/10.1155/2020/9627954 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832546899721191424 |
|---|---|
| author | Nataliya Kutsevol Yuliia Kuziv Tetiana Bezugla Vasyl Chumachenko Vasyl Chekhun |
| author_facet | Nataliya Kutsevol Yuliia Kuziv Tetiana Bezugla Vasyl Chumachenko Vasyl Chekhun |
| author_sort | Nataliya Kutsevol |
| collection | DOAJ |
| description | Multicomponent nanocomposites for anticancer therapy were prepared, characterized, and tested for their antitumor efficacy. The water-soluble star-like dextran-graft-polyacrylamide copolymer was used as a nanoplatform for the creation of polymer-based multicomponent drug delivery systems for photodynamic and combined (photodynamic+chemotherapy) antitumor therapy. The three-component nanocomposites with incorporated gold nanoparticles and photosensitizer and the four-component ones additionally loaded by Doxorubicin into polymer nanoplatform were studied at 25 and 37°C by transmission electron microscopy and dynamic light scattering. Nanocomposites were tested for their photodynamic cytotoxicity for the cell line of breast cancer MCF-7/S. Three-component nanocomposites demonstrated higher efficacy than the four-component ones. The decrease in the activity of the four-component systems is explained by the aggregation process caused by the introduction of an additional component, which leads to a decrease in the hydrophilic-hydrophobic balance of the polymer macromolecule. |
| format | Article |
| id | doaj-art-b8d7b0b29b0c456587d8ec0631871877 |
| institution | Kabale University |
| issn | 1687-9422 1687-9430 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Polymer Science |
| spelling | doaj-art-b8d7b0b29b0c456587d8ec06318718772025-02-03T06:46:41ZengWileyInternational Journal of Polymer Science1687-94221687-94302020-01-01202010.1155/2020/96279549627954Multicomponent Nanocomposites for Complex Anticancer Therapy: Effect of Aggregation Processes on Their EfficacyNataliya Kutsevol0Yuliia Kuziv1Tetiana Bezugla2Vasyl Chumachenko3Vasyl Chekhun4Taras Shevchenko National University of Kyiv, 60 Volodymyrska Str., 01602 Kyiv, UkraineTaras Shevchenko National University of Kyiv, 60 Volodymyrska Str., 01602 Kyiv, UkraineTaras Shevchenko National University of Kyiv, 60 Volodymyrska Str., 01602 Kyiv, UkraineTaras Shevchenko National University of Kyiv, 60 Volodymyrska Str., 01602 Kyiv, UkraineR.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology, 45 Vasylkivska Str., 03022 Kyiv, UkraineMulticomponent nanocomposites for anticancer therapy were prepared, characterized, and tested for their antitumor efficacy. The water-soluble star-like dextran-graft-polyacrylamide copolymer was used as a nanoplatform for the creation of polymer-based multicomponent drug delivery systems for photodynamic and combined (photodynamic+chemotherapy) antitumor therapy. The three-component nanocomposites with incorporated gold nanoparticles and photosensitizer and the four-component ones additionally loaded by Doxorubicin into polymer nanoplatform were studied at 25 and 37°C by transmission electron microscopy and dynamic light scattering. Nanocomposites were tested for their photodynamic cytotoxicity for the cell line of breast cancer MCF-7/S. Three-component nanocomposites demonstrated higher efficacy than the four-component ones. The decrease in the activity of the four-component systems is explained by the aggregation process caused by the introduction of an additional component, which leads to a decrease in the hydrophilic-hydrophobic balance of the polymer macromolecule.http://dx.doi.org/10.1155/2020/9627954 |
| spellingShingle | Nataliya Kutsevol Yuliia Kuziv Tetiana Bezugla Vasyl Chumachenko Vasyl Chekhun Multicomponent Nanocomposites for Complex Anticancer Therapy: Effect of Aggregation Processes on Their Efficacy International Journal of Polymer Science |
| title | Multicomponent Nanocomposites for Complex Anticancer Therapy: Effect of Aggregation Processes on Their Efficacy |
| title_full | Multicomponent Nanocomposites for Complex Anticancer Therapy: Effect of Aggregation Processes on Their Efficacy |
| title_fullStr | Multicomponent Nanocomposites for Complex Anticancer Therapy: Effect of Aggregation Processes on Their Efficacy |
| title_full_unstemmed | Multicomponent Nanocomposites for Complex Anticancer Therapy: Effect of Aggregation Processes on Their Efficacy |
| title_short | Multicomponent Nanocomposites for Complex Anticancer Therapy: Effect of Aggregation Processes on Their Efficacy |
| title_sort | multicomponent nanocomposites for complex anticancer therapy effect of aggregation processes on their efficacy |
| url | http://dx.doi.org/10.1155/2020/9627954 |
| work_keys_str_mv | AT nataliyakutsevol multicomponentnanocompositesforcomplexanticancertherapyeffectofaggregationprocessesontheirefficacy AT yuliiakuziv multicomponentnanocompositesforcomplexanticancertherapyeffectofaggregationprocessesontheirefficacy AT tetianabezugla multicomponentnanocompositesforcomplexanticancertherapyeffectofaggregationprocessesontheirefficacy AT vasylchumachenko multicomponentnanocompositesforcomplexanticancertherapyeffectofaggregationprocessesontheirefficacy AT vasylchekhun multicomponentnanocompositesforcomplexanticancertherapyeffectofaggregationprocessesontheirefficacy |