Besides and beyond histopathology; for adjuvant treatment in early tongue cancer
Oral tongue squamous cell carcinomas differ significantly from that of other subsites of oral cavity in relation to clinical behavior. They are more aggressive and have a poorer prognosis. The treatment of choice of early (stage I and II) tongue cancers is surgery. The need for adjuvant treatment is...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Thieme Medical and Scientific Publishers Pvt. Ltd.
2018-01-01
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| Series: | Indian Journal of Medical and Paediatric Oncology |
| Subjects: | |
| Online Access: | http://www.ijmpo.org/article.asp?issn=0971-5851;year=2018;volume=39;issue=3;spage=355;epage=362;aulast=Chakrabarti |
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| _version_ | 1849727487324454912 |
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| author | Swagnik Chakrabarti Shreshtha Ghosh Burhanuddin N Qayyumi Akshat Malik Deepa Nair Sudhir Nair Pankaj Chaturvedi J P Agrawal |
| author_facet | Swagnik Chakrabarti Shreshtha Ghosh Burhanuddin N Qayyumi Akshat Malik Deepa Nair Sudhir Nair Pankaj Chaturvedi J P Agrawal |
| author_sort | Swagnik Chakrabarti |
| collection | DOAJ |
| description | Oral tongue squamous cell carcinomas differ significantly from that of other subsites of oral cavity in relation to clinical behavior. They are more aggressive and have a poorer prognosis. The treatment of choice of early (stage I and II) tongue cancers is surgery. The need for adjuvant treatment is decided on the basis of the histopathology report of the surgical specimen. High-risk patients (positive surgical margins, perineural invasion, lymphovascular spread, lymph node metastasis, and extracapsular extension) receive adjuvant treatment while others are observed. Unfortunately, in the apparently low-risk patients who are observed, there is a high rate of locoregional failure. There are certain histopathology parameters though not routinely validated may be of prognostic significance in this subset of patients. In this review, we have highlighted the importance of the routinely validated and the nonvalidated histopathology parameters and their proper assessment in the decision-making for adjuvant treatment of patients with early tongue cancers. |
| format | Article |
| id | doaj-art-b8d19606cff0443cb3c94de3129774b1 |
| institution | DOAJ |
| issn | 0971-5851 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Thieme Medical and Scientific Publishers Pvt. Ltd. |
| record_format | Article |
| series | Indian Journal of Medical and Paediatric Oncology |
| spelling | doaj-art-b8d19606cff0443cb3c94de3129774b12025-08-20T03:09:49ZengThieme Medical and Scientific Publishers Pvt. Ltd.Indian Journal of Medical and Paediatric Oncology0971-58512018-01-0139335536210.4103/ijmpo.ijmpo_204_16Besides and beyond histopathology; for adjuvant treatment in early tongue cancerSwagnik ChakrabartiShreshtha GhoshBurhanuddin N QayyumiAkshat MalikDeepa NairSudhir NairPankaj ChaturvediJ P AgrawalOral tongue squamous cell carcinomas differ significantly from that of other subsites of oral cavity in relation to clinical behavior. They are more aggressive and have a poorer prognosis. The treatment of choice of early (stage I and II) tongue cancers is surgery. The need for adjuvant treatment is decided on the basis of the histopathology report of the surgical specimen. High-risk patients (positive surgical margins, perineural invasion, lymphovascular spread, lymph node metastasis, and extracapsular extension) receive adjuvant treatment while others are observed. Unfortunately, in the apparently low-risk patients who are observed, there is a high rate of locoregional failure. There are certain histopathology parameters though not routinely validated may be of prognostic significance in this subset of patients. In this review, we have highlighted the importance of the routinely validated and the nonvalidated histopathology parameters and their proper assessment in the decision-making for adjuvant treatment of patients with early tongue cancers.http://www.ijmpo.org/article.asp?issn=0971-5851;year=2018;volume=39;issue=3;spage=355;epage=362;aulast=ChakrabartiAdjuvant therapy in tongue cancersearly squamous cell carcinoma tongueindications for radiotherapy in tongue cancersmolecular markers in tongue cancers |
| spellingShingle | Swagnik Chakrabarti Shreshtha Ghosh Burhanuddin N Qayyumi Akshat Malik Deepa Nair Sudhir Nair Pankaj Chaturvedi J P Agrawal Besides and beyond histopathology; for adjuvant treatment in early tongue cancer Indian Journal of Medical and Paediatric Oncology Adjuvant therapy in tongue cancers early squamous cell carcinoma tongue indications for radiotherapy in tongue cancers molecular markers in tongue cancers |
| title | Besides and beyond histopathology; for adjuvant treatment in early tongue cancer |
| title_full | Besides and beyond histopathology; for adjuvant treatment in early tongue cancer |
| title_fullStr | Besides and beyond histopathology; for adjuvant treatment in early tongue cancer |
| title_full_unstemmed | Besides and beyond histopathology; for adjuvant treatment in early tongue cancer |
| title_short | Besides and beyond histopathology; for adjuvant treatment in early tongue cancer |
| title_sort | besides and beyond histopathology for adjuvant treatment in early tongue cancer |
| topic | Adjuvant therapy in tongue cancers early squamous cell carcinoma tongue indications for radiotherapy in tongue cancers molecular markers in tongue cancers |
| url | http://www.ijmpo.org/article.asp?issn=0971-5851;year=2018;volume=39;issue=3;spage=355;epage=362;aulast=Chakrabarti |
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