In Vitro Activities of Ertapenem and Imipenem against Clinical Extended Spectrum Beta-Lactamase-Producing Enterobacteriaceae Collected in Military Teaching Hospital Mohammed V of Rabat
Objective. To study the sensitivity level of extended spectrum beta-lactamase-producing Enterobacteriaceae to Carbapenems (Imipenem, Ertapenem) marketed in Morocco and discusses the place of Ertapenem in the treatment of extended spectrum-beta-lactamase-producing. Materials and Methods. A retrospect...
Saved in:
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2012-01-01
|
| Series: | Interdisciplinary Perspectives on Infectious Diseases |
| Online Access: | http://dx.doi.org/10.1155/2012/646480 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832564849429708800 |
|---|---|
| author | M. Elouennass A. Zohoun A. El Ameri N. Alem J. Kasouati Y. Benlahlou I. El Yaagoubi M. Frikh A. Lemnouer A. Benouda |
| author_facet | M. Elouennass A. Zohoun A. El Ameri N. Alem J. Kasouati Y. Benlahlou I. El Yaagoubi M. Frikh A. Lemnouer A. Benouda |
| author_sort | M. Elouennass |
| collection | DOAJ |
| description | Objective. To study the sensitivity level of extended spectrum beta-lactamase-producing Enterobacteriaceae to Carbapenems (Imipenem, Ertapenem) marketed in Morocco and discusses the place of Ertapenem in the treatment of extended spectrum-beta-lactamase-producing. Materials and Methods. A retrospective study of 110 extended spectrum beta-lactamase-producing Enterobacteriaceae. Isolates obtained from blood cultures, superficial and deep pus, and catheters were conducted. The minimum inhibitory concentrations of Imipenem and Ertapenem were done by the E-test. The modified Hodge test was conducted for resistant or intermediate strains. Results. 99.1% of isolates were susceptible to Imipenem. For Ertapenem, 4 were resistant and 4 intermediate. The modified Hodge test was positive for all 08 isolates. A minimum inhibitory concentration comparison of K. pneumoniae, E. cloacae, and E. coli for Imipenem has noted a significant difference between E. cloacae on one hand and E. coli, K. pneumoniae on the other hand (𝑃<0.01). No significant difference was noted for minimum inhibitory concentration of Ertapenem. Conclusion. Our results confirm in vitro effectiveness of Ertapenem against extended spectrum beta-lactamase-producing Enterobacteriaceae as reported elsewhere. However, the emergence of resistance to Carbapenems revealed by production of carbapenemases in this study confirmed a necessary bacteriological documented infection before using Ertapenem. |
| format | Article |
| id | doaj-art-b8c4a9ad27fd4431b2b6db6968f233b2 |
| institution | Kabale University |
| issn | 1687-708X 1687-7098 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Interdisciplinary Perspectives on Infectious Diseases |
| spelling | doaj-art-b8c4a9ad27fd4431b2b6db6968f233b22025-02-03T01:10:07ZengWileyInterdisciplinary Perspectives on Infectious Diseases1687-708X1687-70982012-01-01201210.1155/2012/646480646480In Vitro Activities of Ertapenem and Imipenem against Clinical Extended Spectrum Beta-Lactamase-Producing Enterobacteriaceae Collected in Military Teaching Hospital Mohammed V of RabatM. Elouennass0A. Zohoun1A. El Ameri2N. Alem3J. Kasouati4Y. Benlahlou5I. El Yaagoubi6M. Frikh7A. Lemnouer8A. Benouda9Department of Bacteriology, Military Teaching Hospital Mohammed V and Faculty of Medicine and Pharmacy, Mohammed V University, Souissi, Rabat, MoroccoDepartment of Bacteriology, Military Teaching Hospital Mohammed V and Faculty of Medicine and Pharmacy, Mohammed V University, Souissi, Rabat, MoroccoDepartment of Bacteriology, Military Teaching Hospital Mohammed V and Faculty of Medicine and Pharmacy, Mohammed V University, Souissi, Rabat, MoroccoDepartment of Bacteriology, Military Teaching Hospital Mohammed V and Faculty of Medicine and Pharmacy, Mohammed V University, Souissi, Rabat, MoroccoLaboratory of Biostatistics, Faculty of Medicine and Pharmacy, Mohammed V University, Souissi, Rabat, MoroccoDepartment of Bacteriology, Military Teaching Hospital Mohammed V and Faculty of Medicine and Pharmacy, Mohammed V University, Souissi, Rabat, MoroccoDepartment of Bacteriology, Military Teaching Hospital Mohammed V and Faculty of Medicine and Pharmacy, Mohammed V University, Souissi, Rabat, MoroccoDepartment of Bacteriology, Military Teaching Hospital Mohammed V and Faculty of Medicine and Pharmacy, Mohammed V University, Souissi, Rabat, MoroccoDepartment of Bacteriology, Military Teaching Hospital Mohammed V and Faculty of Medicine and Pharmacy, Mohammed V University, Souissi, Rabat, MoroccoStudy Research Group for Antibiotic Resistance and Bacterial Infections, Faculty of Medicine and Pharmacy, Mohammed V University, Souissi, Rabat, MoroccoObjective. To study the sensitivity level of extended spectrum beta-lactamase-producing Enterobacteriaceae to Carbapenems (Imipenem, Ertapenem) marketed in Morocco and discusses the place of Ertapenem in the treatment of extended spectrum-beta-lactamase-producing. Materials and Methods. A retrospective study of 110 extended spectrum beta-lactamase-producing Enterobacteriaceae. Isolates obtained from blood cultures, superficial and deep pus, and catheters were conducted. The minimum inhibitory concentrations of Imipenem and Ertapenem were done by the E-test. The modified Hodge test was conducted for resistant or intermediate strains. Results. 99.1% of isolates were susceptible to Imipenem. For Ertapenem, 4 were resistant and 4 intermediate. The modified Hodge test was positive for all 08 isolates. A minimum inhibitory concentration comparison of K. pneumoniae, E. cloacae, and E. coli for Imipenem has noted a significant difference between E. cloacae on one hand and E. coli, K. pneumoniae on the other hand (𝑃<0.01). No significant difference was noted for minimum inhibitory concentration of Ertapenem. Conclusion. Our results confirm in vitro effectiveness of Ertapenem against extended spectrum beta-lactamase-producing Enterobacteriaceae as reported elsewhere. However, the emergence of resistance to Carbapenems revealed by production of carbapenemases in this study confirmed a necessary bacteriological documented infection before using Ertapenem.http://dx.doi.org/10.1155/2012/646480 |
| spellingShingle | M. Elouennass A. Zohoun A. El Ameri N. Alem J. Kasouati Y. Benlahlou I. El Yaagoubi M. Frikh A. Lemnouer A. Benouda In Vitro Activities of Ertapenem and Imipenem against Clinical Extended Spectrum Beta-Lactamase-Producing Enterobacteriaceae Collected in Military Teaching Hospital Mohammed V of Rabat Interdisciplinary Perspectives on Infectious Diseases |
| title | In Vitro Activities of Ertapenem and Imipenem against Clinical Extended Spectrum Beta-Lactamase-Producing Enterobacteriaceae Collected in Military Teaching Hospital Mohammed V of Rabat |
| title_full | In Vitro Activities of Ertapenem and Imipenem against Clinical Extended Spectrum Beta-Lactamase-Producing Enterobacteriaceae Collected in Military Teaching Hospital Mohammed V of Rabat |
| title_fullStr | In Vitro Activities of Ertapenem and Imipenem against Clinical Extended Spectrum Beta-Lactamase-Producing Enterobacteriaceae Collected in Military Teaching Hospital Mohammed V of Rabat |
| title_full_unstemmed | In Vitro Activities of Ertapenem and Imipenem against Clinical Extended Spectrum Beta-Lactamase-Producing Enterobacteriaceae Collected in Military Teaching Hospital Mohammed V of Rabat |
| title_short | In Vitro Activities of Ertapenem and Imipenem against Clinical Extended Spectrum Beta-Lactamase-Producing Enterobacteriaceae Collected in Military Teaching Hospital Mohammed V of Rabat |
| title_sort | in vitro activities of ertapenem and imipenem against clinical extended spectrum beta lactamase producing enterobacteriaceae collected in military teaching hospital mohammed v of rabat |
| url | http://dx.doi.org/10.1155/2012/646480 |
| work_keys_str_mv | AT melouennass invitroactivitiesofertapenemandimipenemagainstclinicalextendedspectrumbetalactamaseproducingenterobacteriaceaecollectedinmilitaryteachinghospitalmohammedvofrabat AT azohoun invitroactivitiesofertapenemandimipenemagainstclinicalextendedspectrumbetalactamaseproducingenterobacteriaceaecollectedinmilitaryteachinghospitalmohammedvofrabat AT aelameri invitroactivitiesofertapenemandimipenemagainstclinicalextendedspectrumbetalactamaseproducingenterobacteriaceaecollectedinmilitaryteachinghospitalmohammedvofrabat AT nalem invitroactivitiesofertapenemandimipenemagainstclinicalextendedspectrumbetalactamaseproducingenterobacteriaceaecollectedinmilitaryteachinghospitalmohammedvofrabat AT jkasouati invitroactivitiesofertapenemandimipenemagainstclinicalextendedspectrumbetalactamaseproducingenterobacteriaceaecollectedinmilitaryteachinghospitalmohammedvofrabat AT ybenlahlou invitroactivitiesofertapenemandimipenemagainstclinicalextendedspectrumbetalactamaseproducingenterobacteriaceaecollectedinmilitaryteachinghospitalmohammedvofrabat AT ielyaagoubi invitroactivitiesofertapenemandimipenemagainstclinicalextendedspectrumbetalactamaseproducingenterobacteriaceaecollectedinmilitaryteachinghospitalmohammedvofrabat AT mfrikh invitroactivitiesofertapenemandimipenemagainstclinicalextendedspectrumbetalactamaseproducingenterobacteriaceaecollectedinmilitaryteachinghospitalmohammedvofrabat AT alemnouer invitroactivitiesofertapenemandimipenemagainstclinicalextendedspectrumbetalactamaseproducingenterobacteriaceaecollectedinmilitaryteachinghospitalmohammedvofrabat AT abenouda invitroactivitiesofertapenemandimipenemagainstclinicalextendedspectrumbetalactamaseproducingenterobacteriaceaecollectedinmilitaryteachinghospitalmohammedvofrabat |