2-Brain Regulation for Improved Neuroprotection during Early Development (2-BRAINED): a translational hyperscanning research project
IntroductionVery preterm (VPT) birth is a major risk condition for child development and parental wellbeing, mainly due to multiple sources of stress (e.g., separation and pain exposure) during the neonatal intensive care unit (NICU) stay. Early video-feedback (VF) interventions proved effective in...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Psychology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpsyg.2024.1516616/full |
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| author | Lucia Billeci Valentina Riva Elena Capelli Serena Grumi Miriam Paola Pili Maddalena Cassa Eleonora Siri Elisa Roberti Renato Borgatti Renato Borgatti Livio Provenzi Livio Provenzi |
| author_facet | Lucia Billeci Valentina Riva Elena Capelli Serena Grumi Miriam Paola Pili Maddalena Cassa Eleonora Siri Elisa Roberti Renato Borgatti Renato Borgatti Livio Provenzi Livio Provenzi |
| author_sort | Lucia Billeci |
| collection | DOAJ |
| description | IntroductionVery preterm (VPT) birth is a major risk condition for child development and parental wellbeing, mainly due to multiple sources of stress (e.g., separation and pain exposure) during the neonatal intensive care unit (NICU) stay. Early video-feedback (VF) interventions proved effective in promoting VOT infants’ development and parental wellbeing. Electroencephalography (EEG) hyperscanning allows the assessment of brain-to-brain co-regulation during live interaction between infants and parents, offering promising insights into the mechanisms behind the interactive benefits of early VF interventions.GoalsThis study aimed to compare indices of brain-to-brain co-regulation between dyads of full-term (FT) and VPT infants interacting with their mothers and investigate the effect of an early post-discharge VF intervention on the brain-to-brain co-regulation indices of VPT dyads.Methods and analysisVPT and FT dyads will be enrolled at birth, and the former will be randomly allocated to one of two arms: VF intervention or care as usual. Short-term effectiveness will be assessed through ratings of mother–infant interaction videotaped before and after the VF intervention or care as usual. Mothers of VPT and FT infants will report on their mental state, parenting stress and bonding, and infant temperament and sensory profile at 3 and 6 months (corrected age, CA). At 9 months CA, all dyads will participate in a lab-based EEG-hyperscanning paradigm to assess brain-to-brain co-regulation through phase-locking value (PLV) and other explorative indices.Ethics and disseminationThis study was funded by the Italian Ministry of Health and received approval by the Ethics Committee of Pavia (Italy) and participating hospitals. Research findings will be reported in scientific publications, presented at international conferences, and disseminated to the general public.Study registration numberGR-2021-12375213 (Italian Ministry of Health registry). |
| format | Article |
| id | doaj-art-b8bcb24722c44dc0ad43a933097e6620 |
| institution | Kabale University |
| issn | 1664-1078 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Psychology |
| spelling | doaj-art-b8bcb24722c44dc0ad43a933097e66202025-01-28T06:41:18ZengFrontiers Media S.A.Frontiers in Psychology1664-10782025-01-011510.3389/fpsyg.2024.151661615166162-Brain Regulation for Improved Neuroprotection during Early Development (2-BRAINED): a translational hyperscanning research projectLucia Billeci0Valentina Riva1Elena Capelli2Serena Grumi3Miriam Paola Pili4Maddalena Cassa5Eleonora Siri6Elisa Roberti7Renato Borgatti8Renato Borgatti9Livio Provenzi10Livio Provenzi11Clinical Physiology Institute, National Research Council of Italy (IFC-CNR), Pisa, ItalyChild Psychopathology Unit, Scientific Institute IRCCS E. Medea, Bosisio Parini, ItalyDepartment of Brain and Behavioral Sciences, University of Pavia, Pavia, ItalyDevelopmental Psychobiology Lab, IRCCS Mondino Foundation, Pavia, ItalyDepartment of Brain and Behavioral Sciences, University of Pavia, Pavia, ItalyChild Psychopathology Unit, Scientific Institute IRCCS E. Medea, Bosisio Parini, ItalyChild Psychopathology Unit, Scientific Institute IRCCS E. Medea, Bosisio Parini, ItalyDevelopmental Psychobiology Lab, IRCCS Mondino Foundation, Pavia, ItalyDepartment of Brain and Behavioral Sciences, University of Pavia, Pavia, ItalyChild Neurology and Psychiatry Unit, IRCCS Mondino Foundation, Pavia, ItalyDepartment of Brain and Behavioral Sciences, University of Pavia, Pavia, ItalyDevelopmental Psychobiology Lab, IRCCS Mondino Foundation, Pavia, ItalyIntroductionVery preterm (VPT) birth is a major risk condition for child development and parental wellbeing, mainly due to multiple sources of stress (e.g., separation and pain exposure) during the neonatal intensive care unit (NICU) stay. Early video-feedback (VF) interventions proved effective in promoting VOT infants’ development and parental wellbeing. Electroencephalography (EEG) hyperscanning allows the assessment of brain-to-brain co-regulation during live interaction between infants and parents, offering promising insights into the mechanisms behind the interactive benefits of early VF interventions.GoalsThis study aimed to compare indices of brain-to-brain co-regulation between dyads of full-term (FT) and VPT infants interacting with their mothers and investigate the effect of an early post-discharge VF intervention on the brain-to-brain co-regulation indices of VPT dyads.Methods and analysisVPT and FT dyads will be enrolled at birth, and the former will be randomly allocated to one of two arms: VF intervention or care as usual. Short-term effectiveness will be assessed through ratings of mother–infant interaction videotaped before and after the VF intervention or care as usual. Mothers of VPT and FT infants will report on their mental state, parenting stress and bonding, and infant temperament and sensory profile at 3 and 6 months (corrected age, CA). At 9 months CA, all dyads will participate in a lab-based EEG-hyperscanning paradigm to assess brain-to-brain co-regulation through phase-locking value (PLV) and other explorative indices.Ethics and disseminationThis study was funded by the Italian Ministry of Health and received approval by the Ethics Committee of Pavia (Italy) and participating hospitals. Research findings will be reported in scientific publications, presented at international conferences, and disseminated to the general public.Study registration numberGR-2021-12375213 (Italian Ministry of Health registry).https://www.frontiersin.org/articles/10.3389/fpsyg.2024.1516616/fullEEGhyperscanninginfantparentpretermsynchrony |
| spellingShingle | Lucia Billeci Valentina Riva Elena Capelli Serena Grumi Miriam Paola Pili Maddalena Cassa Eleonora Siri Elisa Roberti Renato Borgatti Renato Borgatti Livio Provenzi Livio Provenzi 2-Brain Regulation for Improved Neuroprotection during Early Development (2-BRAINED): a translational hyperscanning research project Frontiers in Psychology EEG hyperscanning infant parent preterm synchrony |
| title | 2-Brain Regulation for Improved Neuroprotection during Early Development (2-BRAINED): a translational hyperscanning research project |
| title_full | 2-Brain Regulation for Improved Neuroprotection during Early Development (2-BRAINED): a translational hyperscanning research project |
| title_fullStr | 2-Brain Regulation for Improved Neuroprotection during Early Development (2-BRAINED): a translational hyperscanning research project |
| title_full_unstemmed | 2-Brain Regulation for Improved Neuroprotection during Early Development (2-BRAINED): a translational hyperscanning research project |
| title_short | 2-Brain Regulation for Improved Neuroprotection during Early Development (2-BRAINED): a translational hyperscanning research project |
| title_sort | 2 brain regulation for improved neuroprotection during early development 2 brained a translational hyperscanning research project |
| topic | EEG hyperscanning infant parent preterm synchrony |
| url | https://www.frontiersin.org/articles/10.3389/fpsyg.2024.1516616/full |
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