RNA splicing: a split consensus reveals two major 5′ splice site classes

The established consensus sequence for human 5′ splice sites masks the presence of two major splice site classes defined by preferential base-pairing potentials with either U5 snRNA loop 1 or the U6 snRNA ACAGA box. The two 5′ splice site classes are separable in genome sequences, sensitized by spec...

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Bibliographic Details
Main Authors: Matthew T. Parker, Sebastian M. Fica, Gordon G. Simpson
Format: Article
Language:English
Published: The Royal Society 2025-01-01
Series:Open Biology
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Online Access:https://royalsocietypublishing.org/doi/10.1098/rsob.240293
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