Changes in Locomotor Activity Observed During Acute Nicotine Withdrawal Can Be Attenuated by Ghrelin and GHRP-6 in Rats
<b>Background/Objectives:</b> Ghrelin and growth hormone-releasing peptide 6 (GHRP-6) are peptides which can stimulate GH release, acting through the same receptor. Ghrelin and its receptor have been involved in reward sensation and addiction induced by natural and artificial drugs, incl...
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2025-01-01
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| author | Jázmin Ayman András Buzás Roberta Dochnal Miklós Palotai Miklós Jászberényi Zsolt Bagosi |
| author_facet | Jázmin Ayman András Buzás Roberta Dochnal Miklós Palotai Miklós Jászberényi Zsolt Bagosi |
| author_sort | Jázmin Ayman |
| collection | DOAJ |
| description | <b>Background/Objectives:</b> Ghrelin and growth hormone-releasing peptide 6 (GHRP-6) are peptides which can stimulate GH release, acting through the same receptor. Ghrelin and its receptor have been involved in reward sensation and addiction induced by natural and artificial drugs, including nicotine. The present study aimed to investigate the impacts of ghrelin and GHRP-6 on the horizontal and vertical activity in rats exposed to chronic nicotine treatment followed by acute nicotine withdrawal. <b>Methods:</b> Male and female Wistar rats were exposed daily to intraperitoneal (ip) injection with 2 mg/kg nicotine or saline solution for 7 days, twice a day (at 8:00 and at 20:00). In parallel, the rats were exposed daily to an intracerebroventricular (icv) injection with 1 μg/2 μL ghrelin or 1 μg/2 μL GHRP-6 or saline solution for 7 days, once a day (at 8:00). On the morning of the eighth day (12 h after the last ip administration) and the ninth day (24 h after the last ip administration), the horizontal and vertical activity were monitored in a conducta system. <b>Results:</b> On the eighth day, in nicotine-treated rats a significant hyperactivity was observed, that was reduced significantly by ghrelin and GHRP-6. On the ninth day, in nicotine-treated rats a significant hypoactivity was assessed that was reversed significantly by ghrelin and GHRP-6. <b>Conclusions:</b> Based on the present results, the changes in horizontal and vertical activity observed after 12 and 24 h of nicotine withdrawal can be attenuated by ghrelin and GHRP-6. |
| format | Article |
| id | doaj-art-b8b9ea9659fe4b74a212cbea8b8da7c6 |
| institution | Kabale University |
| issn | 2227-9059 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj-art-b8b9ea9659fe4b74a212cbea8b8da7c62025-01-24T13:24:10ZengMDPI AGBiomedicines2227-90592025-01-0113114310.3390/biomedicines13010143Changes in Locomotor Activity Observed During Acute Nicotine Withdrawal Can Be Attenuated by Ghrelin and GHRP-6 in RatsJázmin Ayman0András Buzás1Roberta Dochnal2Miklós Palotai3Miklós Jászberényi4Zsolt Bagosi5Department of Obstetrics and Gynecology, Albert Szent-Györgyi Medical School, University of Szeged, 6725 Szeged, HungaryDepartment of Surgery, Albert Szent-Györgyi Medical School, University of Szeged, 6725 Szeged, HungaryDepartment of Pediatrics and Pedriatic Health Center, Albert Szent-Györgyi Medical School, University of Szeged, 6725 Szeged, HungaryDepartment of Radiology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USADepartment of Pathophysiology, Albert Szent-Györgyi Medical School, University of Szeged, Szőkefalvi-Nagy Béla str. 6., 6720 Szeged, HungaryDepartment of Pathophysiology, Albert Szent-Györgyi Medical School, University of Szeged, Szőkefalvi-Nagy Béla str. 6., 6720 Szeged, Hungary<b>Background/Objectives:</b> Ghrelin and growth hormone-releasing peptide 6 (GHRP-6) are peptides which can stimulate GH release, acting through the same receptor. Ghrelin and its receptor have been involved in reward sensation and addiction induced by natural and artificial drugs, including nicotine. The present study aimed to investigate the impacts of ghrelin and GHRP-6 on the horizontal and vertical activity in rats exposed to chronic nicotine treatment followed by acute nicotine withdrawal. <b>Methods:</b> Male and female Wistar rats were exposed daily to intraperitoneal (ip) injection with 2 mg/kg nicotine or saline solution for 7 days, twice a day (at 8:00 and at 20:00). In parallel, the rats were exposed daily to an intracerebroventricular (icv) injection with 1 μg/2 μL ghrelin or 1 μg/2 μL GHRP-6 or saline solution for 7 days, once a day (at 8:00). On the morning of the eighth day (12 h after the last ip administration) and the ninth day (24 h after the last ip administration), the horizontal and vertical activity were monitored in a conducta system. <b>Results:</b> On the eighth day, in nicotine-treated rats a significant hyperactivity was observed, that was reduced significantly by ghrelin and GHRP-6. On the ninth day, in nicotine-treated rats a significant hypoactivity was assessed that was reversed significantly by ghrelin and GHRP-6. <b>Conclusions:</b> Based on the present results, the changes in horizontal and vertical activity observed after 12 and 24 h of nicotine withdrawal can be attenuated by ghrelin and GHRP-6.https://www.mdpi.com/2227-9059/13/1/143nicotineghrelinGHRP-6dopaminerats |
| spellingShingle | Jázmin Ayman András Buzás Roberta Dochnal Miklós Palotai Miklós Jászberényi Zsolt Bagosi Changes in Locomotor Activity Observed During Acute Nicotine Withdrawal Can Be Attenuated by Ghrelin and GHRP-6 in Rats Biomedicines nicotine ghrelin GHRP-6 dopamine rats |
| title | Changes in Locomotor Activity Observed During Acute Nicotine Withdrawal Can Be Attenuated by Ghrelin and GHRP-6 in Rats |
| title_full | Changes in Locomotor Activity Observed During Acute Nicotine Withdrawal Can Be Attenuated by Ghrelin and GHRP-6 in Rats |
| title_fullStr | Changes in Locomotor Activity Observed During Acute Nicotine Withdrawal Can Be Attenuated by Ghrelin and GHRP-6 in Rats |
| title_full_unstemmed | Changes in Locomotor Activity Observed During Acute Nicotine Withdrawal Can Be Attenuated by Ghrelin and GHRP-6 in Rats |
| title_short | Changes in Locomotor Activity Observed During Acute Nicotine Withdrawal Can Be Attenuated by Ghrelin and GHRP-6 in Rats |
| title_sort | changes in locomotor activity observed during acute nicotine withdrawal can be attenuated by ghrelin and ghrp 6 in rats |
| topic | nicotine ghrelin GHRP-6 dopamine rats |
| url | https://www.mdpi.com/2227-9059/13/1/143 |
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