Association of TNF-857C>T, TNFRSF1A36A>G, and TNFRSF1B676T>G Polymorphisms with Ischemic Stroke in a Greek Population
Background. The role of genetic factors in the predisposition to develop ischemic stroke has been assessed by previous studies. The main goal of the current study was to determine any possible role of TNF-857C>T,TNFRSF1A36A>G, and TNFRSF1B676T>G polymorphisms in risk for stroke. Materials a...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Stroke Research and Treatment |
| Online Access: | http://dx.doi.org/10.4061/2011/920584 |
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| author | Sofia Markoula Anthoula Chatzikyriakidou Sotirios Giannopoulos Kargiotis Odysseas Sofia Markou Konstantinos Vemmos Ioannis Georgiou Athanassios P. Kyritsis |
| author_facet | Sofia Markoula Anthoula Chatzikyriakidou Sotirios Giannopoulos Kargiotis Odysseas Sofia Markou Konstantinos Vemmos Ioannis Georgiou Athanassios P. Kyritsis |
| author_sort | Sofia Markoula |
| collection | DOAJ |
| description | Background. The role of genetic factors in the predisposition to develop ischemic stroke has been assessed by previous studies. The main goal of the current study was to determine any possible role of TNF-857C>T,TNFRSF1A36A>G, and TNFRSF1B676T>G polymorphisms in risk for stroke. Materials and Methods. One hundred seventy-three patients with first ever ischemic stroke of solely atherosclerotic etiology in Northwest Greece and a control group of 179 healthy unrelated subjects were evaluated. Results. TNFα-857TT, TNFR136AA, and TNFR2676TT genotypes were significantly increased in the patient group compared to controls (𝑃=.008, OR = 2.47 (1.26–4.84), 𝑃=.005, OR = 1.97 (1.22–3.17), and 𝑃=.003, OR = 2.2 (1.43–3.37), resp.). In addition, the TNFR136A and the TNFR2676T alleles were found significantly increased in patients compared to controls (𝑃=.009, OR = 1.48 (1.1–2) and 𝑃=.001, OR = 1.75 (1.25–2.46), resp.). Conclusion. The high incidence of these genotypes and alleles in patient group suggests that they are potentially predisposing factors for stroke in the Greek population studied. Large-scale multicenter controlled studies are needed to verify these polymorphisms effects on stroke susceptibility. |
| format | Article |
| id | doaj-art-b8a940eba84c4243bd730c1bdd34d27c |
| institution | Kabale University |
| issn | 2042-0056 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stroke Research and Treatment |
| spelling | doaj-art-b8a940eba84c4243bd730c1bdd34d27c2025-02-03T05:45:50ZengWileyStroke Research and Treatment2042-00562011-01-01201110.4061/2011/920584920584Association of TNF-857C>T, TNFRSF1A36A>G, and TNFRSF1B676T>G Polymorphisms with Ischemic Stroke in a Greek PopulationSofia Markoula0Anthoula Chatzikyriakidou1Sotirios Giannopoulos2Kargiotis Odysseas3Sofia Markou4Konstantinos Vemmos5Ioannis Georgiou6Athanassios P. Kyritsis7Department of Neurology, School of Medicine, University of Ioannina, University Campus, 45110 Ioannina, GreeceLaboratory of Medical Genetics, School of Medicine, University of Ioannina, University Campus, 45110 Ioannina, GreeceDepartment of Neurology, School of Medicine, University of Ioannina, University Campus, 45110 Ioannina, GreeceNeurosurgical Research Institute, School of Medicine, University of Ioannina, 45110 Ioannina, GreeceDepartment of Neurology, School of Medicine, University of Ioannina, University Campus, 45110 Ioannina, GreeceDepartment of Clinical Therapeutics, National and Kapodistrian, University of Athens, 11528 Athens, GreeceLaboratory of Medical Genetics, School of Medicine, University of Ioannina, University Campus, 45110 Ioannina, GreeceDepartment of Neurology, School of Medicine, University of Ioannina, University Campus, 45110 Ioannina, GreeceBackground. The role of genetic factors in the predisposition to develop ischemic stroke has been assessed by previous studies. The main goal of the current study was to determine any possible role of TNF-857C>T,TNFRSF1A36A>G, and TNFRSF1B676T>G polymorphisms in risk for stroke. Materials and Methods. One hundred seventy-three patients with first ever ischemic stroke of solely atherosclerotic etiology in Northwest Greece and a control group of 179 healthy unrelated subjects were evaluated. Results. TNFα-857TT, TNFR136AA, and TNFR2676TT genotypes were significantly increased in the patient group compared to controls (𝑃=.008, OR = 2.47 (1.26–4.84), 𝑃=.005, OR = 1.97 (1.22–3.17), and 𝑃=.003, OR = 2.2 (1.43–3.37), resp.). In addition, the TNFR136A and the TNFR2676T alleles were found significantly increased in patients compared to controls (𝑃=.009, OR = 1.48 (1.1–2) and 𝑃=.001, OR = 1.75 (1.25–2.46), resp.). Conclusion. The high incidence of these genotypes and alleles in patient group suggests that they are potentially predisposing factors for stroke in the Greek population studied. Large-scale multicenter controlled studies are needed to verify these polymorphisms effects on stroke susceptibility.http://dx.doi.org/10.4061/2011/920584 |
| spellingShingle | Sofia Markoula Anthoula Chatzikyriakidou Sotirios Giannopoulos Kargiotis Odysseas Sofia Markou Konstantinos Vemmos Ioannis Georgiou Athanassios P. Kyritsis Association of TNF-857C>T, TNFRSF1A36A>G, and TNFRSF1B676T>G Polymorphisms with Ischemic Stroke in a Greek Population Stroke Research and Treatment |
| title | Association of TNF-857C>T, TNFRSF1A36A>G, and TNFRSF1B676T>G Polymorphisms with Ischemic Stroke in a Greek Population |
| title_full | Association of TNF-857C>T, TNFRSF1A36A>G, and TNFRSF1B676T>G Polymorphisms with Ischemic Stroke in a Greek Population |
| title_fullStr | Association of TNF-857C>T, TNFRSF1A36A>G, and TNFRSF1B676T>G Polymorphisms with Ischemic Stroke in a Greek Population |
| title_full_unstemmed | Association of TNF-857C>T, TNFRSF1A36A>G, and TNFRSF1B676T>G Polymorphisms with Ischemic Stroke in a Greek Population |
| title_short | Association of TNF-857C>T, TNFRSF1A36A>G, and TNFRSF1B676T>G Polymorphisms with Ischemic Stroke in a Greek Population |
| title_sort | association of tnf 857c t tnfrsf1a36a g and tnfrsf1b676t g polymorphisms with ischemic stroke in a greek population |
| url | http://dx.doi.org/10.4061/2011/920584 |
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