Interaction between bacterial adhesins leads to coaggregation by the oral bacteria Veillonella parvula and Streptococcus gordonii
ABSTRACT Veillonella parvula is an unusual diderm firmicute that plays a central role in the formation of dental biofilm formation through coaggregation with many other oral bacteria. However, the molecular interactions leading to oral biofilm formation are largely unknown. In a recent study (L. Dor...
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American Society for Microbiology
2025-02-01
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| Series: | mBio |
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| Online Access: | https://journals.asm.org/doi/10.1128/mbio.03279-24 |
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| author | Jack C. Leo |
| author_facet | Jack C. Leo |
| author_sort | Jack C. Leo |
| collection | DOAJ |
| description | ABSTRACT Veillonella parvula is an unusual diderm firmicute that plays a central role in the formation of dental biofilm formation through coaggregation with many other oral bacteria. However, the molecular interactions leading to oral biofilm formation are largely unknown. In a recent study (L. Dorison, N. Béchon, C. Martin-Gallausiaux, S. Chamorro-Rodriguez, et al., mBio 15:e02171-24, 2024, https://doi.org/10.1128/mbio.02171-24), coaggregation by V. parvula was shown to be mediated by trimeric autotransporter adhesins (TAAs), which are large, fibrous surface proteins widespread in Gram-negative bacteria. Importantly, this study identified the binding partner protein on a coaggregating bacterium, Streptococcus gordonii, which the authors called VisA. This finding is the first time a TAA mediating coaggregation with a different type of protein has been established and suggests that specifically interacting protein partners may have coevolved multiple times to allow complex biofilm formation, as exemplified by the development of dental plaque. Understanding these interactions might lead to innovations to reduce build-up of dental plaque and associated oral diseases. |
| format | Article |
| id | doaj-art-b8a63e6073c24818b5c549d15689daa6 |
| institution | Kabale University |
| issn | 2150-7511 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | American Society for Microbiology |
| record_format | Article |
| series | mBio |
| spelling | doaj-art-b8a63e6073c24818b5c549d15689daa62025-02-05T14:00:47ZengAmerican Society for MicrobiologymBio2150-75112025-02-0116210.1128/mbio.03279-24Interaction between bacterial adhesins leads to coaggregation by the oral bacteria Veillonella parvula and Streptococcus gordoniiJack C. Leo0Antimicrobial Resistance, Omics and Microbiota Group, Centre for Systems Health and Integrated Metabolic Research, Department of Biosciences, Nottingham Trent University, Nottingham, United KingdomABSTRACT Veillonella parvula is an unusual diderm firmicute that plays a central role in the formation of dental biofilm formation through coaggregation with many other oral bacteria. However, the molecular interactions leading to oral biofilm formation are largely unknown. In a recent study (L. Dorison, N. Béchon, C. Martin-Gallausiaux, S. Chamorro-Rodriguez, et al., mBio 15:e02171-24, 2024, https://doi.org/10.1128/mbio.02171-24), coaggregation by V. parvula was shown to be mediated by trimeric autotransporter adhesins (TAAs), which are large, fibrous surface proteins widespread in Gram-negative bacteria. Importantly, this study identified the binding partner protein on a coaggregating bacterium, Streptococcus gordonii, which the authors called VisA. This finding is the first time a TAA mediating coaggregation with a different type of protein has been established and suggests that specifically interacting protein partners may have coevolved multiple times to allow complex biofilm formation, as exemplified by the development of dental plaque. Understanding these interactions might lead to innovations to reduce build-up of dental plaque and associated oral diseases.https://journals.asm.org/doi/10.1128/mbio.03279-24Veillonella parvulacoaggregationStreptococcus gordoniioral biofilmtrimeric autotransporter adhesin |
| spellingShingle | Jack C. Leo Interaction between bacterial adhesins leads to coaggregation by the oral bacteria Veillonella parvula and Streptococcus gordonii mBio Veillonella parvula coaggregation Streptococcus gordonii oral biofilm trimeric autotransporter adhesin |
| title | Interaction between bacterial adhesins leads to coaggregation by the oral bacteria Veillonella parvula and Streptococcus gordonii |
| title_full | Interaction between bacterial adhesins leads to coaggregation by the oral bacteria Veillonella parvula and Streptococcus gordonii |
| title_fullStr | Interaction between bacterial adhesins leads to coaggregation by the oral bacteria Veillonella parvula and Streptococcus gordonii |
| title_full_unstemmed | Interaction between bacterial adhesins leads to coaggregation by the oral bacteria Veillonella parvula and Streptococcus gordonii |
| title_short | Interaction between bacterial adhesins leads to coaggregation by the oral bacteria Veillonella parvula and Streptococcus gordonii |
| title_sort | interaction between bacterial adhesins leads to coaggregation by the oral bacteria veillonella parvula and streptococcus gordonii |
| topic | Veillonella parvula coaggregation Streptococcus gordonii oral biofilm trimeric autotransporter adhesin |
| url | https://journals.asm.org/doi/10.1128/mbio.03279-24 |
| work_keys_str_mv | AT jackcleo interactionbetweenbacterialadhesinsleadstocoaggregationbytheoralbacteriaveillonellaparvulaandstreptococcusgordonii |