A pilot study comparing three-dimensional models of tumor histopathology and magnetic resonance imaging
Abstract Three-dimensional (3D) modeling is often used to provide better visual understanding. This has become an everyday tool especially in medical imaging. However, modeling soft tissue histopathology in 3D is in its early stages, thus making 3D comparison between radiology and histopathology dif...
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Nature Portfolio
2025-01-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-025-85478-1 |
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| author | Anne Koivuholma Heli J. Sistonen Katri Aro Antti Mäkitie Jaana Hagström Timo Atula |
| author_facet | Anne Koivuholma Heli J. Sistonen Katri Aro Antti Mäkitie Jaana Hagström Timo Atula |
| author_sort | Anne Koivuholma |
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| description | Abstract Three-dimensional (3D) modeling is often used to provide better visual understanding. This has become an everyday tool especially in medical imaging. However, modeling soft tissue histopathology in 3D is in its early stages, thus making 3D comparison between radiology and histopathology difficult. Here, we sought to create a model that combines a model based on histopathological tumor borders and a model reformatted from magnetic resonance image (MRI). The 3D models were constructed from an oral squamous cell carcinoma (OSCC) resection specimen and a preoperative MRI scan. Potential challenges were identified, and respective solutions proposed. The 3D model based on histopathological tumor borders was constructed by a method that uses a 3D table scanner and modeling software. The 3D MRI model was constructed using 3D Slicer software. The two models were fitted together by anatomical landmarks in each model. We compared the volume and dimensions between the two 3D models. As a result, we created an image fusion that presents the soft-tissue resection specimen, its histopathological findings, and the MRI findings combined in a digital 3D form. Presenting these two 3D models within the resection specimen can serve as a tool to improve the multidisciplinary discussion of patient management. To create these models, only a few additional steps to a normal protocol are required. |
| format | Article |
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| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
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| spelling | doaj-art-b89ea83c2eea4d8797b3ad87fc36e49d2025-01-19T12:20:49ZengNature PortfolioScientific Reports2045-23222025-01-011511810.1038/s41598-025-85478-1A pilot study comparing three-dimensional models of tumor histopathology and magnetic resonance imagingAnne Koivuholma0Heli J. Sistonen1Katri Aro2Antti Mäkitie3Jaana Hagström4Timo Atula5Department of Otorhinolaryngology - Head and Neck Surgery, University of Helsinki and Helsinki University HospitalDepartment of Radiology, University of Helsinki and Helsinki University HospitalDepartment of Otorhinolaryngology - Head and Neck Surgery, University of Helsinki and Helsinki University HospitalDepartment of Otorhinolaryngology - Head and Neck Surgery, University of Helsinki and Helsinki University HospitalDepartment of Pathology, HUSLAB, Helsinki University Hospital and University of HelsinkiDepartment of Otorhinolaryngology - Head and Neck Surgery, University of Helsinki and Helsinki University HospitalAbstract Three-dimensional (3D) modeling is often used to provide better visual understanding. This has become an everyday tool especially in medical imaging. However, modeling soft tissue histopathology in 3D is in its early stages, thus making 3D comparison between radiology and histopathology difficult. Here, we sought to create a model that combines a model based on histopathological tumor borders and a model reformatted from magnetic resonance image (MRI). The 3D models were constructed from an oral squamous cell carcinoma (OSCC) resection specimen and a preoperative MRI scan. Potential challenges were identified, and respective solutions proposed. The 3D model based on histopathological tumor borders was constructed by a method that uses a 3D table scanner and modeling software. The 3D MRI model was constructed using 3D Slicer software. The two models were fitted together by anatomical landmarks in each model. We compared the volume and dimensions between the two 3D models. As a result, we created an image fusion that presents the soft-tissue resection specimen, its histopathological findings, and the MRI findings combined in a digital 3D form. Presenting these two 3D models within the resection specimen can serve as a tool to improve the multidisciplinary discussion of patient management. To create these models, only a few additional steps to a normal protocol are required.https://doi.org/10.1038/s41598-025-85478-1HistopathologyThree-dimensional reconstructionComputer aided designTongueRadiologyOral squamous cell carcinoma |
| spellingShingle | Anne Koivuholma Heli J. Sistonen Katri Aro Antti Mäkitie Jaana Hagström Timo Atula A pilot study comparing three-dimensional models of tumor histopathology and magnetic resonance imaging Scientific Reports Histopathology Three-dimensional reconstruction Computer aided design Tongue Radiology Oral squamous cell carcinoma |
| title | A pilot study comparing three-dimensional models of tumor histopathology and magnetic resonance imaging |
| title_full | A pilot study comparing three-dimensional models of tumor histopathology and magnetic resonance imaging |
| title_fullStr | A pilot study comparing three-dimensional models of tumor histopathology and magnetic resonance imaging |
| title_full_unstemmed | A pilot study comparing three-dimensional models of tumor histopathology and magnetic resonance imaging |
| title_short | A pilot study comparing three-dimensional models of tumor histopathology and magnetic resonance imaging |
| title_sort | pilot study comparing three dimensional models of tumor histopathology and magnetic resonance imaging |
| topic | Histopathology Three-dimensional reconstruction Computer aided design Tongue Radiology Oral squamous cell carcinoma |
| url | https://doi.org/10.1038/s41598-025-85478-1 |
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