Advancements in Regenerative Medicine for Articular Cartilage Repair in the Management of Osteoarthritis: A Review of Modern Treatment Methods
Osteoarthritis (OA) is the most common form of chronic joint diseases, and its treatment still remains difficult with the current state of medicine. In this review, modern regenerative methods used in the repair of articular cartilage, both traditional techniques and innovative cellular therapies,...
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| Format: | Article |
| Language: | English |
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Nicolaus Copernicus University in Toruń
2025-01-01
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| Series: | Quality in Sport |
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| Online Access: | https://apcz.umk.pl/QS/article/view/57092 |
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| author | Jakub Dziewic Maria Przygoda Joanna Śnieżna Gabriela Trestka Kamila Stępień Sabina Adamczyk Urszula Zelik Wojciech Florczak Wiktoria Domino Jagienka Włodyka Karol Dzwonnik |
| author_facet | Jakub Dziewic Maria Przygoda Joanna Śnieżna Gabriela Trestka Kamila Stępień Sabina Adamczyk Urszula Zelik Wojciech Florczak Wiktoria Domino Jagienka Włodyka Karol Dzwonnik |
| author_sort | Jakub Dziewic |
| collection | DOAJ |
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Osteoarthritis (OA) is the most common form of chronic joint diseases, and its treatment still remains difficult with the current state of medicine. In this review, modern regenerative methods used in the repair of articular cartilage, both traditional techniques and innovative cellular therapies, are described. It focuses on the most updated treatment modalities, discussing, among other methods, microfracture, osteochondral grafts, autologous chondrocyte implantation (ACI), novel approaches of matrix-assisted autologous chondrocyte transplantation (MACT) and mesenchymal stem cell (MSC) treatments, with especial regard toward the use of platelet-rich plasma (PRP) in relation to other intra-articular injections, namely hyaluronic acid and ozone therapy. The regenerative treatments analyzed in this review have great potential in cartilage defect repair and possible symptom alleviation for OA; long-term efficacy, however, and limitations of cost and invasiveness do have to be more extensively considered. Another discussion concerns macrophages, modulators of the inflammatory environment of the joint, and whether they could serve as potential therapeutic targets. The need for further investigation, in order to modify the existing methods and create other effective regenerative approaches in patients suffering from OA, is presented.
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| format | Article |
| id | doaj-art-b899e46ced0f4213a7cbe213d17940a0 |
| institution | Kabale University |
| issn | 2450-3118 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nicolaus Copernicus University in Toruń |
| record_format | Article |
| series | Quality in Sport |
| spelling | doaj-art-b899e46ced0f4213a7cbe213d17940a02025-01-20T08:23:25ZengNicolaus Copernicus University in ToruńQuality in Sport2450-31182025-01-013710.12775/QS.2025.37.57092Advancements in Regenerative Medicine for Articular Cartilage Repair in the Management of Osteoarthritis: A Review of Modern Treatment MethodsJakub Dziewic0https://orcid.org/0009-0008-4338-4573Maria Przygoda1https://orcid.org/0000-0002-6409-7265Joanna Śnieżna2https://orcid.org/0009-0006-2713-0835Gabriela Trestka3https://orcid.org/0009-0009-9504-8923Kamila Stępień4https://orcid.org/0009-0000-3579-9308Sabina Adamczyk5https://orcid.org/0009-0003-9671-6619Urszula Zelik6https://orcid.org/0009-0009-3369-7936Wojciech Florczak7https://orcid.org/0009-0006-8003-0999Wiktoria Domino8https://orcid.org/0009-0005-0034-7463Jagienka Włodyka9https://orcid.org/0009-0000-7243-7023Karol Dzwonnik10https://orcid.org/0009-0007-1366-3945Medical University of LublinSpecialist Hospital named after Stefan Żeromski, Independent Public Healthcare Facility (SP ZOZ), in KrakówMedical University of LublinClinical Provincial Hospital No. 2 in Rzeszów, Poland Lwowska 60, 35-501 Rzeszów, PolandIndependent Public Health Care Facility of the Ministry of Internal Affairs and Administration in Kielce, Poland Wojska Polskiego 51, 25-375 Kielce, PolandIndependent Public Healthcare Facility of the Ministry of Internal Affairs and Administration in Opole, PolandUniversity Teaching Hospital them F. Chopin in Rzeszów, Poland Fryderyka Szopena 2, 35-055 Rzeszów, PolandMedical University of LublinClinical Provincial Hospital No. 2 in Rzeszów, Poland Lwowska 60, 35-501 Rzeszów, PolandUniversity Teaching Hospital them F. Chopin in Rzeszów, Poland Fryderyka Szopena 2, 35-055 Rzeszów, PolandMedical University of Lublin Osteoarthritis (OA) is the most common form of chronic joint diseases, and its treatment still remains difficult with the current state of medicine. In this review, modern regenerative methods used in the repair of articular cartilage, both traditional techniques and innovative cellular therapies, are described. It focuses on the most updated treatment modalities, discussing, among other methods, microfracture, osteochondral grafts, autologous chondrocyte implantation (ACI), novel approaches of matrix-assisted autologous chondrocyte transplantation (MACT) and mesenchymal stem cell (MSC) treatments, with especial regard toward the use of platelet-rich plasma (PRP) in relation to other intra-articular injections, namely hyaluronic acid and ozone therapy. The regenerative treatments analyzed in this review have great potential in cartilage defect repair and possible symptom alleviation for OA; long-term efficacy, however, and limitations of cost and invasiveness do have to be more extensively considered. Another discussion concerns macrophages, modulators of the inflammatory environment of the joint, and whether they could serve as potential therapeutic targets. The need for further investigation, in order to modify the existing methods and create other effective regenerative approaches in patients suffering from OA, is presented. https://apcz.umk.pl/QS/article/view/57092osteoarthritisarticular cartilage repairstem cellsregenerative medicinecartilage regeneration |
| spellingShingle | Jakub Dziewic Maria Przygoda Joanna Śnieżna Gabriela Trestka Kamila Stępień Sabina Adamczyk Urszula Zelik Wojciech Florczak Wiktoria Domino Jagienka Włodyka Karol Dzwonnik Advancements in Regenerative Medicine for Articular Cartilage Repair in the Management of Osteoarthritis: A Review of Modern Treatment Methods Quality in Sport osteoarthritis articular cartilage repair stem cells regenerative medicine cartilage regeneration |
| title | Advancements in Regenerative Medicine for Articular Cartilage Repair in the Management of Osteoarthritis: A Review of Modern Treatment Methods |
| title_full | Advancements in Regenerative Medicine for Articular Cartilage Repair in the Management of Osteoarthritis: A Review of Modern Treatment Methods |
| title_fullStr | Advancements in Regenerative Medicine for Articular Cartilage Repair in the Management of Osteoarthritis: A Review of Modern Treatment Methods |
| title_full_unstemmed | Advancements in Regenerative Medicine for Articular Cartilage Repair in the Management of Osteoarthritis: A Review of Modern Treatment Methods |
| title_short | Advancements in Regenerative Medicine for Articular Cartilage Repair in the Management of Osteoarthritis: A Review of Modern Treatment Methods |
| title_sort | advancements in regenerative medicine for articular cartilage repair in the management of osteoarthritis a review of modern treatment methods |
| topic | osteoarthritis articular cartilage repair stem cells regenerative medicine cartilage regeneration |
| url | https://apcz.umk.pl/QS/article/view/57092 |
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