Rockwood Clinical Frailty Scale as a predictor of adverse outcomes among older adults undergoing aortic valve replacement: a protocol for a systematic review
Introduction Frailty is associated with adverse outcomes relating to cardiac procedures. It has been proposed that frailty scoring should be included in the preoperative assessment of patients undergoing aortic valve replacement. We aim to examine the Rockwood Clinical Frailty Scale (CFS), as a pred...
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BMJ Publishing Group
2022-01-01
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| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/12/1/e049216.full |
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| author | Rose Galvin Ahmed Gabr Catherine Peters Margaret O'Connor Aoife Leahy Elaine Shanahan Tadhg Prendiville Laura Quinlan Anastasia Saleh Ivan Casserly |
| author_facet | Rose Galvin Ahmed Gabr Catherine Peters Margaret O'Connor Aoife Leahy Elaine Shanahan Tadhg Prendiville Laura Quinlan Anastasia Saleh Ivan Casserly |
| author_sort | Rose Galvin |
| collection | DOAJ |
| description | Introduction Frailty is associated with adverse outcomes relating to cardiac procedures. It has been proposed that frailty scoring should be included in the preoperative assessment of patients undergoing aortic valve replacement. We aim to examine the Rockwood Clinical Frailty Scale (CFS), as a predictor of adverse outcomes following aortic valve replacement.Methods and analysis Prospective and retrospective cohort studies and randomised controlled trials assessing both the preoperative frailty status (as per the CFS) and incidence of adverse outcomes among older adults undergoing either surgical aortic valve replacement or transcatheter aortic valve replacement will be included. Adverse outcomes will include mortality and periprocedural complications, as well as a composite of 30-day complications. A search will be conducted from 2005 to present using a prespecified search strategy. Studies will be screened for inclusion by two reviewers, with methodological quality assessed using the Quality Assessment of Diagnostic Accuracy Studies (QUADAS-2) tool. Relative risk ratios with 95% CIs will be generated for each outcome of interest, comparing frail with non-frail groups. Data will be plotted on forest plots where applicable. The quality of the evidence will be determined using the Grading of Recommendations, Assessment, Development and Evaluation tool.Ethics and dissemination Ethical approval is not required for this study as no primary data will be collected. We will publish the review in a peer-reviewed journal on completion.PROSPERO registration number CRD42020213757. |
| format | Article |
| id | doaj-art-b883fdf98d9b481aa0a34a0e741df3b2 |
| institution | Kabale University |
| issn | 2044-6055 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | BMJ Publishing Group |
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| series | BMJ Open |
| spelling | doaj-art-b883fdf98d9b481aa0a34a0e741df3b22025-02-02T04:10:12ZengBMJ Publishing GroupBMJ Open2044-60552022-01-0112110.1136/bmjopen-2021-049216Rockwood Clinical Frailty Scale as a predictor of adverse outcomes among older adults undergoing aortic valve replacement: a protocol for a systematic reviewRose Galvin0Ahmed Gabr1Catherine Peters2Margaret O'Connor3Aoife Leahy4Elaine Shanahan5Tadhg Prendiville6Laura Quinlan7Anastasia Saleh8Ivan Casserly9School of Allied Health, University of Limerick Faculty of Education and Health Sciences, Health Research Institute, Limerick, IrelandDepartment of Ageing and Therapeutics, University Hospital Limerick, Limerick, IrelandDepartment of Paediatric Endocrinology, Great Ormond Street Hospital, London, UKDepartment of Ageing and Therapeutics, University Hospital Limerick, Dooradoyle, Limerick, IrelandSchool of Allied Health, University of Limerick, Limerick, IrelandDepartment of Ageing and Therapeutics, Univeristy Hospital Limerick, Limerick, IrelandDepartment of Cardiology, Cork University Hospital, Cork, IrelandDepartment of Ageing and Therapeutics, University Hospital Limerick, Dooradoyle, Limerick, IrelandDepartment of Ageing and Therapeutics, University Hospital Limerick, Limerick, IrelandDepartment of Cardiology, Mater Misericordiae University Hospital, Dublin, IrelandIntroduction Frailty is associated with adverse outcomes relating to cardiac procedures. It has been proposed that frailty scoring should be included in the preoperative assessment of patients undergoing aortic valve replacement. We aim to examine the Rockwood Clinical Frailty Scale (CFS), as a predictor of adverse outcomes following aortic valve replacement.Methods and analysis Prospective and retrospective cohort studies and randomised controlled trials assessing both the preoperative frailty status (as per the CFS) and incidence of adverse outcomes among older adults undergoing either surgical aortic valve replacement or transcatheter aortic valve replacement will be included. Adverse outcomes will include mortality and periprocedural complications, as well as a composite of 30-day complications. A search will be conducted from 2005 to present using a prespecified search strategy. Studies will be screened for inclusion by two reviewers, with methodological quality assessed using the Quality Assessment of Diagnostic Accuracy Studies (QUADAS-2) tool. Relative risk ratios with 95% CIs will be generated for each outcome of interest, comparing frail with non-frail groups. Data will be plotted on forest plots where applicable. The quality of the evidence will be determined using the Grading of Recommendations, Assessment, Development and Evaluation tool.Ethics and dissemination Ethical approval is not required for this study as no primary data will be collected. We will publish the review in a peer-reviewed journal on completion.PROSPERO registration number CRD42020213757.https://bmjopen.bmj.com/content/12/1/e049216.full |
| spellingShingle | Rose Galvin Ahmed Gabr Catherine Peters Margaret O'Connor Aoife Leahy Elaine Shanahan Tadhg Prendiville Laura Quinlan Anastasia Saleh Ivan Casserly Rockwood Clinical Frailty Scale as a predictor of adverse outcomes among older adults undergoing aortic valve replacement: a protocol for a systematic review BMJ Open |
| title | Rockwood Clinical Frailty Scale as a predictor of adverse outcomes among older adults undergoing aortic valve replacement: a protocol for a systematic review |
| title_full | Rockwood Clinical Frailty Scale as a predictor of adverse outcomes among older adults undergoing aortic valve replacement: a protocol for a systematic review |
| title_fullStr | Rockwood Clinical Frailty Scale as a predictor of adverse outcomes among older adults undergoing aortic valve replacement: a protocol for a systematic review |
| title_full_unstemmed | Rockwood Clinical Frailty Scale as a predictor of adverse outcomes among older adults undergoing aortic valve replacement: a protocol for a systematic review |
| title_short | Rockwood Clinical Frailty Scale as a predictor of adverse outcomes among older adults undergoing aortic valve replacement: a protocol for a systematic review |
| title_sort | rockwood clinical frailty scale as a predictor of adverse outcomes among older adults undergoing aortic valve replacement a protocol for a systematic review |
| url | https://bmjopen.bmj.com/content/12/1/e049216.full |
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