Asymptomatic Lymphocytic Interstitial Pneumonia with Extensive HRCT Changes Preceding Sjogren’s Syndrome
Lymphocytic interstitial pneumonia (LIP) is a rare condition, commonly associated with Sjogren’s syndrome (SS). We report a 53-year-old woman with an incidental finding of an abnormal chest radiograph. LIP was diagnosed based on high-resolution computed tomography and lung biopsy, but treatment was...
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Wiley
2021-01-01
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| Series: | Case Reports in Pulmonology |
| Online Access: | http://dx.doi.org/10.1155/2021/6693031 |
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| author | Hazlyna Baharuddin Mohammad Hanafiah Syazatul Syakirin Sirol Aflah Mohd Arif Mohd Zim Shereen Suyin Ch’Ng |
| author_facet | Hazlyna Baharuddin Mohammad Hanafiah Syazatul Syakirin Sirol Aflah Mohd Arif Mohd Zim Shereen Suyin Ch’Ng |
| author_sort | Hazlyna Baharuddin |
| collection | DOAJ |
| description | Lymphocytic interstitial pneumonia (LIP) is a rare condition, commonly associated with Sjogren’s syndrome (SS). We report a 53-year-old woman with an incidental finding of an abnormal chest radiograph. LIP was diagnosed based on high-resolution computed tomography and lung biopsy, but treatment was not initiated. Six years later, she developed cough and dyspnoea, associated with dry eyes, dry mouth, and arthralgia. While being investigated for the respiratory symptoms, she developed cutaneous vasculitis and was treated with 1 mg/kg prednisolone, which resulted in the improvement of her respiratory symptoms. Physical examination revealed fine bibasal crepitations, active vasculitic skin lesions, and a positive Schirmer’s test. Investigations revealed a restrictive pattern in the pulmonary function test, stable LIP pattern in HRCT, and positive anti-Ro antibodies. She was treated with prednisolone and azathioprine for 18 months, and within this time, she was hospitalised for flare of LIP, as well as respiratory tract infection on three occasions. During the third flare, when she also developed cutaneous vasculitis, she agreed for prednisolone but refused other second-line agents. To date, she remained well with the maintenance of prednisolone 2.5 mg monotherapy for more than one year. The lessons from this case are (i) patients with LIP can be asymptomatic, (ii) LIP can precede symptoms of SS, and (iii) treatment decision for asymptomatic patients with abnormal imaging or patients with mild severity should be weighed between the risk of immunosuppression and risk of active disease. |
| format | Article |
| id | doaj-art-b883687cf261407bbc0744825ee2bc8a |
| institution | Kabale University |
| issn | 2090-6846 2090-6854 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Pulmonology |
| spelling | doaj-art-b883687cf261407bbc0744825ee2bc8a2025-02-03T00:58:51ZengWileyCase Reports in Pulmonology2090-68462090-68542021-01-01202110.1155/2021/66930316693031Asymptomatic Lymphocytic Interstitial Pneumonia with Extensive HRCT Changes Preceding Sjogren’s SyndromeHazlyna Baharuddin0Mohammad Hanafiah1Syazatul Syakirin Sirol Aflah2Mohd Arif Mohd Zim3Shereen Suyin Ch’Ng4Faculty of Medicine, Universiti Teknologi MARA, MalaysiaFaculty of Medicine, Universiti Teknologi MARA, MalaysiaInstitut Perubatan Respiratori, MalaysiaFaculty of Medicine, Universiti Teknologi MARA, MalaysiaHospital Selayang, MalaysiaLymphocytic interstitial pneumonia (LIP) is a rare condition, commonly associated with Sjogren’s syndrome (SS). We report a 53-year-old woman with an incidental finding of an abnormal chest radiograph. LIP was diagnosed based on high-resolution computed tomography and lung biopsy, but treatment was not initiated. Six years later, she developed cough and dyspnoea, associated with dry eyes, dry mouth, and arthralgia. While being investigated for the respiratory symptoms, she developed cutaneous vasculitis and was treated with 1 mg/kg prednisolone, which resulted in the improvement of her respiratory symptoms. Physical examination revealed fine bibasal crepitations, active vasculitic skin lesions, and a positive Schirmer’s test. Investigations revealed a restrictive pattern in the pulmonary function test, stable LIP pattern in HRCT, and positive anti-Ro antibodies. She was treated with prednisolone and azathioprine for 18 months, and within this time, she was hospitalised for flare of LIP, as well as respiratory tract infection on three occasions. During the third flare, when she also developed cutaneous vasculitis, she agreed for prednisolone but refused other second-line agents. To date, she remained well with the maintenance of prednisolone 2.5 mg monotherapy for more than one year. The lessons from this case are (i) patients with LIP can be asymptomatic, (ii) LIP can precede symptoms of SS, and (iii) treatment decision for asymptomatic patients with abnormal imaging or patients with mild severity should be weighed between the risk of immunosuppression and risk of active disease.http://dx.doi.org/10.1155/2021/6693031 |
| spellingShingle | Hazlyna Baharuddin Mohammad Hanafiah Syazatul Syakirin Sirol Aflah Mohd Arif Mohd Zim Shereen Suyin Ch’Ng Asymptomatic Lymphocytic Interstitial Pneumonia with Extensive HRCT Changes Preceding Sjogren’s Syndrome Case Reports in Pulmonology |
| title | Asymptomatic Lymphocytic Interstitial Pneumonia with Extensive HRCT Changes Preceding Sjogren’s Syndrome |
| title_full | Asymptomatic Lymphocytic Interstitial Pneumonia with Extensive HRCT Changes Preceding Sjogren’s Syndrome |
| title_fullStr | Asymptomatic Lymphocytic Interstitial Pneumonia with Extensive HRCT Changes Preceding Sjogren’s Syndrome |
| title_full_unstemmed | Asymptomatic Lymphocytic Interstitial Pneumonia with Extensive HRCT Changes Preceding Sjogren’s Syndrome |
| title_short | Asymptomatic Lymphocytic Interstitial Pneumonia with Extensive HRCT Changes Preceding Sjogren’s Syndrome |
| title_sort | asymptomatic lymphocytic interstitial pneumonia with extensive hrct changes preceding sjogren s syndrome |
| url | http://dx.doi.org/10.1155/2021/6693031 |
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