Intermittent Fasting Modulation of the Diabetic Syndrome in Streptozotocin-Injected Rats
This study investigates the effects of intermittent overnight fasting in streptozotocin-induced diabetic rats (STZ rats). Over 30 days, groups of 5-6 control or STZ rats were allowed free food access, starved overnight, or exposed to a restricted food supply comparable to that ingested by the interm...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2012/962012 |
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| author | Louiza Belkacemi Ghalem Selselet-Attou Emeline Hupkens Evrard Nguidjoe Karim Louchami Abdullah Sener Willy J. Malaisse |
| author_facet | Louiza Belkacemi Ghalem Selselet-Attou Emeline Hupkens Evrard Nguidjoe Karim Louchami Abdullah Sener Willy J. Malaisse |
| author_sort | Louiza Belkacemi |
| collection | DOAJ |
| description | This study investigates the effects of intermittent overnight fasting in streptozotocin-induced diabetic rats (STZ rats). Over 30 days, groups of 5-6 control or STZ rats were allowed free food access, starved overnight, or exposed to a restricted food supply comparable to that ingested by the intermittently fasting animals. Intermittent fasting improved glucose tolerance, increased plasma insulin, and lowered Homeostatis Model Assessment index. Caloric restriction failed to cause such beneficial effects. The β-cell mass, as well as individual β-cell and islet area, was higher in intermittently fasting than in nonfasting STZ rats, whilst the percentage of apoptotic β-cells appeared lower in the former than latter STZ rats. In the calorie-restricted STZ rats, comparable findings were restricted to individual islet area and percentage of apoptotic cells. Hence, it is proposed that intermittent fasting could represent a possible approach to prevent or minimize disturbances of glucose homeostasis in human subjects. |
| format | Article |
| id | doaj-art-b87e352cb9ed4c4fb4977145f5aebc50 |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-b87e352cb9ed4c4fb4977145f5aebc502025-02-03T01:12:00ZengWileyInternational Journal of Endocrinology1687-83371687-83452012-01-01201210.1155/2012/962012962012Intermittent Fasting Modulation of the Diabetic Syndrome in Streptozotocin-Injected RatsLouiza Belkacemi0Ghalem Selselet-Attou1Emeline Hupkens2Evrard Nguidjoe3Karim Louchami4Abdullah Sener5Willy J. Malaisse6Laboratoire de Technologie Alimentaire et Nutrition, Université de Mostaganem, 1070 Mostaganem, AlgeriaLaboratoire de Technologie Alimentaire et Nutrition, Université de Mostaganem, 1070 Mostaganem, AlgeriaLaboratory of Experimental Hormonology, Université Libre de Bruxelles, 808 Route de Lennik, 1070 Brussels, BelgiumLaboratory of Pharmacology, Université Libre de Bruxelles, 808 Route de Lennik, 1070 Brussels, BelgiumLaboratory of Experimental Hormonology, Université Libre de Bruxelles, 808 Route de Lennik, 1070 Brussels, BelgiumLaboratory of Experimental Hormonology, Université Libre de Bruxelles, 808 Route de Lennik, 1070 Brussels, BelgiumLaboratory of Experimental Hormonology, Université Libre de Bruxelles, 808 Route de Lennik, 1070 Brussels, BelgiumThis study investigates the effects of intermittent overnight fasting in streptozotocin-induced diabetic rats (STZ rats). Over 30 days, groups of 5-6 control or STZ rats were allowed free food access, starved overnight, or exposed to a restricted food supply comparable to that ingested by the intermittently fasting animals. Intermittent fasting improved glucose tolerance, increased plasma insulin, and lowered Homeostatis Model Assessment index. Caloric restriction failed to cause such beneficial effects. The β-cell mass, as well as individual β-cell and islet area, was higher in intermittently fasting than in nonfasting STZ rats, whilst the percentage of apoptotic β-cells appeared lower in the former than latter STZ rats. In the calorie-restricted STZ rats, comparable findings were restricted to individual islet area and percentage of apoptotic cells. Hence, it is proposed that intermittent fasting could represent a possible approach to prevent or minimize disturbances of glucose homeostasis in human subjects.http://dx.doi.org/10.1155/2012/962012 |
| spellingShingle | Louiza Belkacemi Ghalem Selselet-Attou Emeline Hupkens Evrard Nguidjoe Karim Louchami Abdullah Sener Willy J. Malaisse Intermittent Fasting Modulation of the Diabetic Syndrome in Streptozotocin-Injected Rats International Journal of Endocrinology |
| title | Intermittent Fasting Modulation of the Diabetic Syndrome in Streptozotocin-Injected Rats |
| title_full | Intermittent Fasting Modulation of the Diabetic Syndrome in Streptozotocin-Injected Rats |
| title_fullStr | Intermittent Fasting Modulation of the Diabetic Syndrome in Streptozotocin-Injected Rats |
| title_full_unstemmed | Intermittent Fasting Modulation of the Diabetic Syndrome in Streptozotocin-Injected Rats |
| title_short | Intermittent Fasting Modulation of the Diabetic Syndrome in Streptozotocin-Injected Rats |
| title_sort | intermittent fasting modulation of the diabetic syndrome in streptozotocin injected rats |
| url | http://dx.doi.org/10.1155/2012/962012 |
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