Assessment of food toxicology
The interest in food toxicology is evident by the dependency of humankind on nutrition by virtue of their heterotrophic metabolism. By means of modern biochemistry, molecular and cell biology, computer science, bioinformatics as well as high-throughput and high-content screening technologies it has...
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| Format: | Article |
| Language: | English |
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Tsinghua University Press
2016-09-01
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| Series: | Food Science and Human Wellness |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213453016300106 |
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| author | Alexander Gosslau |
| author_facet | Alexander Gosslau |
| author_sort | Alexander Gosslau |
| collection | DOAJ |
| description | The interest in food toxicology is evident by the dependency of humankind on nutrition by virtue of their heterotrophic metabolism. By means of modern biochemistry, molecular and cell biology, computer science, bioinformatics as well as high-throughput and high-content screening technologies it has been possible to identify adverse effects and characterize potential toxicants in food. The mechanisms of toxicant actions are multifactorial but many toxic effects converge on the generation of oxidative stress and chronic inflammation resulting in cell death, aging and degenerative diseases. Integration of food toxicology data obtained throughout biochemical and cell-based in vitro, animal in vivo and human clinical settings has enabled the establishment of alternative, highly predictable in silico models. These systems utilize a combination of complex in vitro cell-based models with computer-based algorithms. A decrease of rodent animal testing with its limitations of high costs, low throughput readouts, inconsistent responses, ethical issues and concerns of extrapolability to humans have led to an increased use of these but also alternative lower hierarchy surrogate animal models (e.g. Drosophila melanogaster; Caenorhabditis elegans or Danio rerio) and efforts to integrate organotypic systems and stem cell-based assays. Despite those achievements, there are numerous challenges in various disciplines of food toxicology. |
| format | Article |
| id | doaj-art-b877216655c14a73b912c7c9abc37f58 |
| institution | Kabale University |
| issn | 2213-4530 |
| language | English |
| publishDate | 2016-09-01 |
| publisher | Tsinghua University Press |
| record_format | Article |
| series | Food Science and Human Wellness |
| spelling | doaj-art-b877216655c14a73b912c7c9abc37f582025-02-03T05:38:39ZengTsinghua University PressFood Science and Human Wellness2213-45302016-09-015310311510.1016/j.fshw.2016.05.003Assessment of food toxicologyAlexander Gosslau0Department of Science (Biology), City University of New York, BMCC, The interest in food toxicology is evident by the dependency of humankind on nutrition by virtue of their heterotrophic metabolism. By means of modern biochemistry, molecular and cell biology, computer science, bioinformatics as well as high-throughput and high-content screening technologies it has been possible to identify adverse effects and characterize potential toxicants in food. The mechanisms of toxicant actions are multifactorial but many toxic effects converge on the generation of oxidative stress and chronic inflammation resulting in cell death, aging and degenerative diseases. Integration of food toxicology data obtained throughout biochemical and cell-based in vitro, animal in vivo and human clinical settings has enabled the establishment of alternative, highly predictable in silico models. These systems utilize a combination of complex in vitro cell-based models with computer-based algorithms. A decrease of rodent animal testing with its limitations of high costs, low throughput readouts, inconsistent responses, ethical issues and concerns of extrapolability to humans have led to an increased use of these but also alternative lower hierarchy surrogate animal models (e.g. Drosophila melanogaster; Caenorhabditis elegans or Danio rerio) and efforts to integrate organotypic systems and stem cell-based assays. Despite those achievements, there are numerous challenges in various disciplines of food toxicology.http://www.sciencedirect.com/science/article/pii/S2213453016300106Food toxicologyOxidative stressInflammationIn vitro, in vivo and in silico modelsAlternative models |
| spellingShingle | Alexander Gosslau Assessment of food toxicology Food Science and Human Wellness Food toxicology Oxidative stress Inflammation In vitro, in vivo and in silico models Alternative models |
| title | Assessment of food toxicology |
| title_full | Assessment of food toxicology |
| title_fullStr | Assessment of food toxicology |
| title_full_unstemmed | Assessment of food toxicology |
| title_short | Assessment of food toxicology |
| title_sort | assessment of food toxicology |
| topic | Food toxicology Oxidative stress Inflammation In vitro, in vivo and in silico models Alternative models |
| url | http://www.sciencedirect.com/science/article/pii/S2213453016300106 |
| work_keys_str_mv | AT alexandergosslau assessmentoffoodtoxicology |