Sulforaphane in alternative cancer chemotherapy: From carcinogenesis suppression to drug resistance reversal
The management and treatment of cancer have posed significant challenges in recent years. Conventional chemotherapy, despite its widespread use, has encountered obstacles such as the emergence of drug resistance. As a result, natural products have gained considerable attention as alternative therapi...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-01-01
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| Series: | Results in Chemistry |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211715625000426 |
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| author | Seyed Mohammad Doodmani Payman Rahimzadeh Najma Farahani Seyedalireza Mirilavasani Mina Alimohammadi Noushin Nabavi Elmira Alaei Afshin Taheriazam Maryam Abedi Nadia Shafiee Salman Daneshi Mehrdad Hashemi |
| author_facet | Seyed Mohammad Doodmani Payman Rahimzadeh Najma Farahani Seyedalireza Mirilavasani Mina Alimohammadi Noushin Nabavi Elmira Alaei Afshin Taheriazam Maryam Abedi Nadia Shafiee Salman Daneshi Mehrdad Hashemi |
| author_sort | Seyed Mohammad Doodmani |
| collection | DOAJ |
| description | The management and treatment of cancer have posed significant challenges in recent years. Conventional chemotherapy, despite its widespread use, has encountered obstacles such as the emergence of drug resistance. As a result, natural products have gained considerable attention as alternative therapies for cancer treatment. These compounds can also be combined with chemotherapy drugs to enhance tumor suppression. Sulforaphane (SFN), a bioactive compound derived from broccoli, has demonstrated remarkable health-promoting properties, including antioxidant, anti-inflammatory, and antidiabetic effects. This review focuses on SFN’s role in cancer treatment, emphasizing its biological mechanisms and ability to regulate drug resistance. Key mechanisms discussed include the regulation of cell death pathways, such as apoptosis, ferroptosis, and autophagy, which are critical in cancer therapy. Additionally, SFN’s ability to suppress metastasis and impair the epithelial-to-mesenchymal transition (EMT) mechanism is highlighted. By inhibiting glycolysis, SFN can reduce the energy supply required for cancer cell proliferation. When combined with chemotherapy drugs, SFN enhances tumor suppression and mitigates drug resistance in human cancers. This is achieved primarily by promoting apoptosis, reducing proliferation, and inhibiting metastasis. In conclusion, SFN shows significant promise in cancer therapy by targeting multiple molecular pathways, improving the efficacy of chemotherapy, and overcoming drug resistance, particularly when incorporated into advanced nanoparticle delivery systems. |
| format | Article |
| id | doaj-art-b87705245b8b4070b226903bdbeb3bd3 |
| institution | Kabale University |
| issn | 2211-7156 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Results in Chemistry |
| spelling | doaj-art-b87705245b8b4070b226903bdbeb3bd32025-01-29T05:01:11ZengElsevierResults in Chemistry2211-71562025-01-0113102059Sulforaphane in alternative cancer chemotherapy: From carcinogenesis suppression to drug resistance reversalSeyed Mohammad Doodmani0Payman Rahimzadeh1Najma Farahani2Seyedalireza Mirilavasani3Mina Alimohammadi4Noushin Nabavi5Elmira Alaei6Afshin Taheriazam7Maryam Abedi8 Nadia Shafiee9Salman Daneshi10Mehrdad Hashemi11Department of Pathobiology, Faculty of Specialized Veterinary Science, Science and Research Branch, Islamic Azad University, Tehran, IranSurgical Research Society (SRS), Students’ Scientific Research Center, Tehran University of Medical Sciences, Tehran, IranFarhikhtegan Medical Convergence Sciences Research Center, Farhikhtegan Hospital Tehran Medical Sciences, Islamic Azad University, Tehran, IranCampus Venlo, Faculty of Health, Medicine and Life Sciences (FHML), Maastricht University, the NetherlandsDepartment of Immunology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, IranIndependent Researcher, Victoria, British Columbia V8V 1P7, CanadaSchool of Medicine, Tehran University of Medical Sciences, Tehran, Iran; Corresponding authors.Farhikhtegan Medical Convergence Sciences Research Center, Farhikhtegan Hospital Tehran Medical Sciences, Islamic Azad University, Tehran, Iran; Department of Orthopedics, Faculty of Medicine, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran; Corresponding authors at: Farhikhtegan Medical Convergence Sciences Research Center, Farhikhtegan Hospital Tehran Medical Sciences, Islamic Azad University, Tehran, Iran.Department of Pathology, Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran; Corresponding authors.Board Certified Otorhinolaryngologist, Bahrami Children Hospital, Tehran University of Medical Sciences, Tehran, Iran; Corresponding authors.Department of Public Health, School of Health,Jiroft University Of Medical Sciences, Jiroft, IranFarhikhtegan Medical Convergence Sciences Research Center, Farhikhtegan Hospital Tehran Medical Sciences, Islamic Azad University, Tehran, Iran; Department of Genetics, Faculty of Advanced Science and Technology, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran; Corresponding authors.The management and treatment of cancer have posed significant challenges in recent years. Conventional chemotherapy, despite its widespread use, has encountered obstacles such as the emergence of drug resistance. As a result, natural products have gained considerable attention as alternative therapies for cancer treatment. These compounds can also be combined with chemotherapy drugs to enhance tumor suppression. Sulforaphane (SFN), a bioactive compound derived from broccoli, has demonstrated remarkable health-promoting properties, including antioxidant, anti-inflammatory, and antidiabetic effects. This review focuses on SFN’s role in cancer treatment, emphasizing its biological mechanisms and ability to regulate drug resistance. Key mechanisms discussed include the regulation of cell death pathways, such as apoptosis, ferroptosis, and autophagy, which are critical in cancer therapy. Additionally, SFN’s ability to suppress metastasis and impair the epithelial-to-mesenchymal transition (EMT) mechanism is highlighted. By inhibiting glycolysis, SFN can reduce the energy supply required for cancer cell proliferation. When combined with chemotherapy drugs, SFN enhances tumor suppression and mitigates drug resistance in human cancers. This is achieved primarily by promoting apoptosis, reducing proliferation, and inhibiting metastasis. In conclusion, SFN shows significant promise in cancer therapy by targeting multiple molecular pathways, improving the efficacy of chemotherapy, and overcoming drug resistance, particularly when incorporated into advanced nanoparticle delivery systems.http://www.sciencedirect.com/science/article/pii/S2211715625000426SulforaphanePhytochemicalsCancer therapyChemoresistance |
| spellingShingle | Seyed Mohammad Doodmani Payman Rahimzadeh Najma Farahani Seyedalireza Mirilavasani Mina Alimohammadi Noushin Nabavi Elmira Alaei Afshin Taheriazam Maryam Abedi Nadia Shafiee Salman Daneshi Mehrdad Hashemi Sulforaphane in alternative cancer chemotherapy: From carcinogenesis suppression to drug resistance reversal Results in Chemistry Sulforaphane Phytochemicals Cancer therapy Chemoresistance |
| title | Sulforaphane in alternative cancer chemotherapy: From carcinogenesis suppression to drug resistance reversal |
| title_full | Sulforaphane in alternative cancer chemotherapy: From carcinogenesis suppression to drug resistance reversal |
| title_fullStr | Sulforaphane in alternative cancer chemotherapy: From carcinogenesis suppression to drug resistance reversal |
| title_full_unstemmed | Sulforaphane in alternative cancer chemotherapy: From carcinogenesis suppression to drug resistance reversal |
| title_short | Sulforaphane in alternative cancer chemotherapy: From carcinogenesis suppression to drug resistance reversal |
| title_sort | sulforaphane in alternative cancer chemotherapy from carcinogenesis suppression to drug resistance reversal |
| topic | Sulforaphane Phytochemicals Cancer therapy Chemoresistance |
| url | http://www.sciencedirect.com/science/article/pii/S2211715625000426 |
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