Central Pontine Myelinolysis with Minimal Hyponatremia in the Setting of AIDS
Central pontine myelinolysis (CPM) is classically attributed to overly rapid correction of profound hyponatremia. However, there are case reports of this disease in the setting of normal serum sodium or minimal hyponatremia. These cases have been hypothesized to be secondary to other metabolic distu...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Case Reports in Neurological Medicine |
| Online Access: | http://dx.doi.org/10.1155/2015/421923 |
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| author | Joseph M. Carrington Galo Sanchez Jennifer L. Berkeley |
| author_facet | Joseph M. Carrington Galo Sanchez Jennifer L. Berkeley |
| author_sort | Joseph M. Carrington |
| collection | DOAJ |
| description | Central pontine myelinolysis (CPM) is classically attributed to overly rapid correction of profound hyponatremia. However, there are case reports of this disease in the setting of normal serum sodium or minimal hyponatremia. These cases have been hypothesized to be secondary to other metabolic disturbances such as hyperglycemia or hypophosphatemia. Eunatremic CPM has also been described in patients with advanced acquired immune deficiency syndrome (AIDS). The mortality risk in this special population is significantly higher than those with hyponatremia-associated CPM, but the mechanisms are unclear. We discuss a case of a man with AIDS who developed CPM with minimal hyponatremia and no other metabolic disturbances. Common variables within this population, such as hypoalbuminemia and lymphoma, are discussed as potential factors contributing to the pathophysiology. Reporting these atypical cases is crucial to our understanding of how to prevent future cases. |
| format | Article |
| id | doaj-art-b87678dd7a01433c9db22df57b11df5b |
| institution | Kabale University |
| issn | 2090-6668 2090-6676 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Neurological Medicine |
| spelling | doaj-art-b87678dd7a01433c9db22df57b11df5b2025-02-03T01:00:56ZengWileyCase Reports in Neurological Medicine2090-66682090-66762015-01-01201510.1155/2015/421923421923Central Pontine Myelinolysis with Minimal Hyponatremia in the Setting of AIDSJoseph M. Carrington0Galo Sanchez1Jennifer L. Berkeley2Department of Internal Medicine, Johns Hopkins University, Sinai Hospital of Baltimore, Baltimore, MD 21215, USADepartment of Internal Medicine, Johns Hopkins University, Sinai Hospital of Baltimore, Baltimore, MD 21215, USADepartment of Neurology, Division of Neurocritical Care, Sinai Hospital of Baltimore, Baltimore, MD 21215, USACentral pontine myelinolysis (CPM) is classically attributed to overly rapid correction of profound hyponatremia. However, there are case reports of this disease in the setting of normal serum sodium or minimal hyponatremia. These cases have been hypothesized to be secondary to other metabolic disturbances such as hyperglycemia or hypophosphatemia. Eunatremic CPM has also been described in patients with advanced acquired immune deficiency syndrome (AIDS). The mortality risk in this special population is significantly higher than those with hyponatremia-associated CPM, but the mechanisms are unclear. We discuss a case of a man with AIDS who developed CPM with minimal hyponatremia and no other metabolic disturbances. Common variables within this population, such as hypoalbuminemia and lymphoma, are discussed as potential factors contributing to the pathophysiology. Reporting these atypical cases is crucial to our understanding of how to prevent future cases.http://dx.doi.org/10.1155/2015/421923 |
| spellingShingle | Joseph M. Carrington Galo Sanchez Jennifer L. Berkeley Central Pontine Myelinolysis with Minimal Hyponatremia in the Setting of AIDS Case Reports in Neurological Medicine |
| title | Central Pontine Myelinolysis with Minimal Hyponatremia in the Setting of AIDS |
| title_full | Central Pontine Myelinolysis with Minimal Hyponatremia in the Setting of AIDS |
| title_fullStr | Central Pontine Myelinolysis with Minimal Hyponatremia in the Setting of AIDS |
| title_full_unstemmed | Central Pontine Myelinolysis with Minimal Hyponatremia in the Setting of AIDS |
| title_short | Central Pontine Myelinolysis with Minimal Hyponatremia in the Setting of AIDS |
| title_sort | central pontine myelinolysis with minimal hyponatremia in the setting of aids |
| url | http://dx.doi.org/10.1155/2015/421923 |
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