Evidence suggesting that microglia make amyloid from neuronally expressed APP: a hypothesis

Abstract While APP is largely neuonally expressed, Aβ amyloid is largely produced by microglia as the clearance mechanisms for damaged membranes becomes overwhelmed.

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Bibliographic Details
Main Authors: John Hardy, Patrick Lewis
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Molecular Neurodegeneration
Online Access:https://doi.org/10.1186/s13024-025-00847-8
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