Advances in Mechanisms of Anaphylaxis in Wheat Allergy: Utility of Rodent Models
Wheat is a staple and nutritious food that is consumed globally. However, it is identified as a major allergenic food because of its capacity to trigger life-threatening systemic anaphylaxis. The specific mechanisms that underlie this systemic anaphylaxis in wheat allergy are incompletely understood...
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| Format: | Article |
| Language: | English |
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MDPI AG
2025-03-01
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| Series: | Foods |
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| Online Access: | https://www.mdpi.com/2304-8158/14/5/883 |
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| author | Tamil Selvan Arul Arasan Rick Jorgensen Chris Van Antwerp Perry K. W. Ng Venu Gangur |
| author_facet | Tamil Selvan Arul Arasan Rick Jorgensen Chris Van Antwerp Perry K. W. Ng Venu Gangur |
| author_sort | Tamil Selvan Arul Arasan |
| collection | DOAJ |
| description | Wheat is a staple and nutritious food that is consumed globally. However, it is identified as a major allergenic food because of its capacity to trigger life-threatening systemic anaphylaxis. The specific mechanisms that underlie this systemic anaphylaxis in wheat allergy are incompletely understood. As a result, several rodent models have been developed to study anaphylaxis in wheat allergies. In this paper, we have conducted a comprehensive review of wheat-induced anaphylaxis using Google Scholar and PubMed databases with relevant keywords. The following objectives were addressed: (1) to determine the complexity of wheat-induced anaphylaxis; (2) to summarize the role of genetic susceptibility in wheat anaphylaxis; (3) to identify the environmental factors involved in the development of wheat anaphylaxis; (4) to map the current status of mechanisms involved in wheat anaphylaxis; (5) to identify the approaches, strengths, and limitations of rodent models of wheat anaphylaxis; and (6) to identify challenges and opportunities in this area of science. Our findings provide a comprehensive updated critical resource for the future research agenda in wheat allergy-associated anaphylaxis, particularly using rodent models as attractive pre-clinical tools. |
| format | Article |
| id | doaj-art-b86b3a5d88274007bdcc64cf32ae2bb5 |
| institution | DOAJ |
| issn | 2304-8158 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Foods |
| spelling | doaj-art-b86b3a5d88274007bdcc64cf32ae2bb52025-08-20T02:53:22ZengMDPI AGFoods2304-81582025-03-0114588310.3390/foods14050883Advances in Mechanisms of Anaphylaxis in Wheat Allergy: Utility of Rodent ModelsTamil Selvan Arul Arasan0Rick Jorgensen1Chris Van Antwerp2Perry K. W. Ng3Venu Gangur4Food Allergy and Immunology Laboratory, Department of Food Science and Human Nutrition, Michigan State University, East Lansing, MI 48824, USAFood Allergy and Immunology Laboratory, Department of Food Science and Human Nutrition, Michigan State University, East Lansing, MI 48824, USAFood Allergy and Immunology Laboratory, Department of Food Science and Human Nutrition, Michigan State University, East Lansing, MI 48824, USACereal Science Laboratory, Department of Food Science and Human Nutrition, Michigan State University, East Lansing, MI 48823, USAFood Allergy and Immunology Laboratory, Department of Food Science and Human Nutrition, Michigan State University, East Lansing, MI 48824, USAWheat is a staple and nutritious food that is consumed globally. However, it is identified as a major allergenic food because of its capacity to trigger life-threatening systemic anaphylaxis. The specific mechanisms that underlie this systemic anaphylaxis in wheat allergy are incompletely understood. As a result, several rodent models have been developed to study anaphylaxis in wheat allergies. In this paper, we have conducted a comprehensive review of wheat-induced anaphylaxis using Google Scholar and PubMed databases with relevant keywords. The following objectives were addressed: (1) to determine the complexity of wheat-induced anaphylaxis; (2) to summarize the role of genetic susceptibility in wheat anaphylaxis; (3) to identify the environmental factors involved in the development of wheat anaphylaxis; (4) to map the current status of mechanisms involved in wheat anaphylaxis; (5) to identify the approaches, strengths, and limitations of rodent models of wheat anaphylaxis; and (6) to identify challenges and opportunities in this area of science. Our findings provide a comprehensive updated critical resource for the future research agenda in wheat allergy-associated anaphylaxis, particularly using rodent models as attractive pre-clinical tools.https://www.mdpi.com/2304-8158/14/5/883wheatwheat glutenwheat non-glutenanaphylaxisanimal modelsIgE |
| spellingShingle | Tamil Selvan Arul Arasan Rick Jorgensen Chris Van Antwerp Perry K. W. Ng Venu Gangur Advances in Mechanisms of Anaphylaxis in Wheat Allergy: Utility of Rodent Models Foods wheat wheat gluten wheat non-gluten anaphylaxis animal models IgE |
| title | Advances in Mechanisms of Anaphylaxis in Wheat Allergy: Utility of Rodent Models |
| title_full | Advances in Mechanisms of Anaphylaxis in Wheat Allergy: Utility of Rodent Models |
| title_fullStr | Advances in Mechanisms of Anaphylaxis in Wheat Allergy: Utility of Rodent Models |
| title_full_unstemmed | Advances in Mechanisms of Anaphylaxis in Wheat Allergy: Utility of Rodent Models |
| title_short | Advances in Mechanisms of Anaphylaxis in Wheat Allergy: Utility of Rodent Models |
| title_sort | advances in mechanisms of anaphylaxis in wheat allergy utility of rodent models |
| topic | wheat wheat gluten wheat non-gluten anaphylaxis animal models IgE |
| url | https://www.mdpi.com/2304-8158/14/5/883 |
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