Postoperative Morbidity and Mortality of Perforated Peptic Ulcer: Retrospective Cohort Study of Risk Factors among Black Africans in Côte d’Ivoire
Introduction. Surgical treatment of perforated peptic ulcer (PPU) is a challenge for surgeons in Africa. Aim. To determine risk factors of postoperative complications or mortality among black Ivoirian patients with PPU. Methods. All 161 patients (median age = 34 years, 90.7 male) operated on for PPU...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2016/2640730 |
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| author | Soro Kountele Gona Mahassadi Kouamé Alassan Koffi Gnangoran Marcellin Kissi Ya Henriette Coulibaly Adama Assohoun Toussaint Ehua Adjoba Manuela Seu Gagon Sylvain Afum-Adjei Awuah Anthony Ehua Somian Francis |
| author_facet | Soro Kountele Gona Mahassadi Kouamé Alassan Koffi Gnangoran Marcellin Kissi Ya Henriette Coulibaly Adama Assohoun Toussaint Ehua Adjoba Manuela Seu Gagon Sylvain Afum-Adjei Awuah Anthony Ehua Somian Francis |
| author_sort | Soro Kountele Gona |
| collection | DOAJ |
| description | Introduction. Surgical treatment of perforated peptic ulcer (PPU) is a challenge for surgeons in Africa. Aim. To determine risk factors of postoperative complications or mortality among black Ivoirian patients with PPU. Methods. All 161 patients (median age = 34 years, 90.7 male) operated on for PPU in the visceral and general surgery unit were enrolled in a retrospective cohort study. Variables were studied with Kaplan Meier and Cox proportional hazard models. Results. Among 161 patients operated on for PPU, 36 (27.5%) experienced complications and 31 (19.3%) died. Follow-up results were the incidence of complications and mortality of 6.4 (95% CI: 4.9–8.0) per 100 person-days and 3.0 (95% CI: 1.9–4.0) per 100 person-days for incidence of mortality. In multivariate analysis, risk factors of postoperative complications or mortality were comorbidities (HR = 2.1, P=0.03), tachycardia (pulse rate > 100/minutes) (HR = 2.4, P=0.02), purulent intra-abdominal fluid collection (HR = 2.1, P=0.04), hyponatremia (median value ≤ 134 mEq/L) (HR = 2.3, P=0.01), delayed time of hospital admission > 72 hours (HR = 2.6, P<0.0001), and delayed time of surgical intervention between 24 and 48 hours (HR = 3.8, P<0.0001). Conclusion. The delayed hospital admission or surgical intervention and hyponatremia may be considered as additional risk of postoperative complications or mortality in Black African patients with PPU. |
| format | Article |
| id | doaj-art-b869f5eca7bc496abf8fe5db085e199a |
| institution | Kabale University |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-b869f5eca7bc496abf8fe5db085e199a2025-02-03T06:01:20ZengWileyGastroenterology Research and Practice1687-61211687-630X2016-01-01201610.1155/2016/26407302640730Postoperative Morbidity and Mortality of Perforated Peptic Ulcer: Retrospective Cohort Study of Risk Factors among Black Africans in Côte d’IvoireSoro Kountele Gona0Mahassadi Kouamé Alassan1Koffi Gnangoran Marcellin2Kissi Ya Henriette3Coulibaly Adama4Assohoun Toussaint5Ehua Adjoba Manuela6Seu Gagon Sylvain7Afum-Adjei Awuah Anthony8Ehua Somian Francis9Service de Chirurgie Digestive et Viscérale, CHU de Yopougon, Côte d’IvoireService de Médecine et d’Hépato-Gastroentérologie, CHU de Yopougon, Côte d’IvoireService de Chirurgie Digestive et Viscérale, CHU de Yopougon, Côte d’IvoireService de Médecine et d’Hépato-Gastroentérologie, CHU de Yopougon, Côte d’IvoireService de Chirurgie Digestive et Viscérale, CHU de Yopougon, Côte d’IvoireService de Chirurgie Digestive et Viscérale, CHU de Yopougon, Côte d’IvoireService de Chirurgie Digestive et Viscérale, CHU de Yopougon, Côte d’IvoireService de Chirurgie Digestive et Viscérale, CHU de Yopougon, Côte d’IvoireKumasi Centre of Collaborative Research in Tropical Medicine, GhanaService des Urgences Médico-Chirurgicales, CHU de Yopougon, Côte d’IvoireIntroduction. Surgical treatment of perforated peptic ulcer (PPU) is a challenge for surgeons in Africa. Aim. To determine risk factors of postoperative complications or mortality among black Ivoirian patients with PPU. Methods. All 161 patients (median age = 34 years, 90.7 male) operated on for PPU in the visceral and general surgery unit were enrolled in a retrospective cohort study. Variables were studied with Kaplan Meier and Cox proportional hazard models. Results. Among 161 patients operated on for PPU, 36 (27.5%) experienced complications and 31 (19.3%) died. Follow-up results were the incidence of complications and mortality of 6.4 (95% CI: 4.9–8.0) per 100 person-days and 3.0 (95% CI: 1.9–4.0) per 100 person-days for incidence of mortality. In multivariate analysis, risk factors of postoperative complications or mortality were comorbidities (HR = 2.1, P=0.03), tachycardia (pulse rate > 100/minutes) (HR = 2.4, P=0.02), purulent intra-abdominal fluid collection (HR = 2.1, P=0.04), hyponatremia (median value ≤ 134 mEq/L) (HR = 2.3, P=0.01), delayed time of hospital admission > 72 hours (HR = 2.6, P<0.0001), and delayed time of surgical intervention between 24 and 48 hours (HR = 3.8, P<0.0001). Conclusion. The delayed hospital admission or surgical intervention and hyponatremia may be considered as additional risk of postoperative complications or mortality in Black African patients with PPU.http://dx.doi.org/10.1155/2016/2640730 |
| spellingShingle | Soro Kountele Gona Mahassadi Kouamé Alassan Koffi Gnangoran Marcellin Kissi Ya Henriette Coulibaly Adama Assohoun Toussaint Ehua Adjoba Manuela Seu Gagon Sylvain Afum-Adjei Awuah Anthony Ehua Somian Francis Postoperative Morbidity and Mortality of Perforated Peptic Ulcer: Retrospective Cohort Study of Risk Factors among Black Africans in Côte d’Ivoire Gastroenterology Research and Practice |
| title | Postoperative Morbidity and Mortality of Perforated Peptic Ulcer: Retrospective Cohort Study of Risk Factors among Black Africans in Côte d’Ivoire |
| title_full | Postoperative Morbidity and Mortality of Perforated Peptic Ulcer: Retrospective Cohort Study of Risk Factors among Black Africans in Côte d’Ivoire |
| title_fullStr | Postoperative Morbidity and Mortality of Perforated Peptic Ulcer: Retrospective Cohort Study of Risk Factors among Black Africans in Côte d’Ivoire |
| title_full_unstemmed | Postoperative Morbidity and Mortality of Perforated Peptic Ulcer: Retrospective Cohort Study of Risk Factors among Black Africans in Côte d’Ivoire |
| title_short | Postoperative Morbidity and Mortality of Perforated Peptic Ulcer: Retrospective Cohort Study of Risk Factors among Black Africans in Côte d’Ivoire |
| title_sort | postoperative morbidity and mortality of perforated peptic ulcer retrospective cohort study of risk factors among black africans in cote d ivoire |
| url | http://dx.doi.org/10.1155/2016/2640730 |
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