Efficacy and safety of 85% phenol and 4% croton oil solution in the treatment of anogenital penile warts: a proof-of-concept study
Introduction: An 85% phenol and 4% croton oil solution (SFC) has cytotoxic effect on the epithelium; however, it has not been evaluated in the treatment of anogenital warts (AGW). Objective: To evaluate the effectiveness of SFC in the treatment of penile AGW in immunocompeten...
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Dermatologia (SBD)
2025-03-01
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| Series: | Surgical & Cosmetic Dermatology |
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| Online Access: | http://www.surgicalcosmetic.org.br/Content/imagebank/pdf/v17/en_v17a334.pdf |
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| author | Maria Cecília Belli Hélio Amante Miot Luis Eduardo Garbers Bruno Dias Martimiano |
| author_facet | Maria Cecília Belli Hélio Amante Miot Luis Eduardo Garbers Bruno Dias Martimiano |
| author_sort | Maria Cecília Belli |
| collection | DOAJ |
| description | Introduction: An 85% phenol and 4% croton oil solution (SFC) has cytotoxic effect on the epithelium;
however, it has not been evaluated in the treatment of anogenital warts (AGW).
Objective: To evaluate the effectiveness of SFC in the treatment of penile AGW in immunocompetent
patients.
Methods: Open, uncontrolled clinical trial (proof-of-concept), involving patients with penile AGW
treated with SFC and reevaluated after 28 days.
RESULTS: We evaluated 16 treatments in 9 participants. SFC promoted total clearance of the lesions in
25% (95% CI 2-48%) of treatments.
Conclusions: Although well tolerated, SFC caused insufficient rates of total clearance. |
| format | Article |
| id | doaj-art-b862c4ffc3bb400aac55b32f6846a508 |
| institution | DOAJ |
| issn | 1984-8773 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Sociedade Brasileira de Dermatologia (SBD) |
| record_format | Article |
| series | Surgical & Cosmetic Dermatology |
| spelling | doaj-art-b862c4ffc3bb400aac55b32f6846a5082025-08-20T03:06:28ZengSociedade Brasileira de Dermatologia (SBD)Surgical & Cosmetic Dermatology1984-87732025-03-011710.5935/scd1984-8773.2025170334Efficacy and safety of 85% phenol and 4% croton oil solution in the treatment of anogenital penile warts: a proof-of-concept studyMaria Cecília Belli0Hélio Amante Miot1Luis Eduardo Garbers2Bruno Dias Martimiano3Unesp, Dermatology, Botucatu (SP), BrazilUnesp, Dermatology, Botucatu (SP), BrazilUnesp, Dermatology, Botucatu (SP), BrazilUnesp, Dermatology, Botucatu (SP), BrazilIntroduction: An 85% phenol and 4% croton oil solution (SFC) has cytotoxic effect on the epithelium; however, it has not been evaluated in the treatment of anogenital warts (AGW). Objective: To evaluate the effectiveness of SFC in the treatment of penile AGW in immunocompetent patients. Methods: Open, uncontrolled clinical trial (proof-of-concept), involving patients with penile AGW treated with SFC and reevaluated after 28 days. RESULTS: We evaluated 16 treatments in 9 participants. SFC promoted total clearance of the lesions in 25% (95% CI 2-48%) of treatments. Conclusions: Although well tolerated, SFC caused insufficient rates of total clearance.http://www.surgicalcosmetic.org.br/Content/imagebank/pdf/v17/en_v17a334.pdfcondylomata acuminataphenolpapillomavirus infectionssexually transmitted diseases |
| spellingShingle | Maria Cecília Belli Hélio Amante Miot Luis Eduardo Garbers Bruno Dias Martimiano Efficacy and safety of 85% phenol and 4% croton oil solution in the treatment of anogenital penile warts: a proof-of-concept study Surgical & Cosmetic Dermatology condylomata acuminata phenol papillomavirus infections sexually transmitted diseases |
| title | Efficacy and safety of 85% phenol and 4% croton oil solution in the treatment of anogenital penile warts: a proof-of-concept study |
| title_full | Efficacy and safety of 85% phenol and 4% croton oil solution in the treatment of anogenital penile warts: a proof-of-concept study |
| title_fullStr | Efficacy and safety of 85% phenol and 4% croton oil solution in the treatment of anogenital penile warts: a proof-of-concept study |
| title_full_unstemmed | Efficacy and safety of 85% phenol and 4% croton oil solution in the treatment of anogenital penile warts: a proof-of-concept study |
| title_short | Efficacy and safety of 85% phenol and 4% croton oil solution in the treatment of anogenital penile warts: a proof-of-concept study |
| title_sort | efficacy and safety of 85 phenol and 4 croton oil solution in the treatment of anogenital penile warts a proof of concept study |
| topic | condylomata acuminata phenol papillomavirus infections sexually transmitted diseases |
| url | http://www.surgicalcosmetic.org.br/Content/imagebank/pdf/v17/en_v17a334.pdf |
| work_keys_str_mv | AT mariaceciliabelli efficacyandsafetyof85phenoland4crotonoilsolutioninthetreatmentofanogenitalpenilewartsaproofofconceptstudy AT helioamantemiot efficacyandsafetyof85phenoland4crotonoilsolutioninthetreatmentofanogenitalpenilewartsaproofofconceptstudy AT luiseduardogarbers efficacyandsafetyof85phenoland4crotonoilsolutioninthetreatmentofanogenitalpenilewartsaproofofconceptstudy AT brunodiasmartimiano efficacyandsafetyof85phenoland4crotonoilsolutioninthetreatmentofanogenitalpenilewartsaproofofconceptstudy |