Efficacy and safety of 85% phenol and 4% croton oil solution in the treatment of anogenital penile warts: a proof-of-concept study
Introduction: An 85% phenol and 4% croton oil solution (SFC) has cytotoxic effect on the epithelium; however, it has not been evaluated in the treatment of anogenital warts (AGW). Objective: To evaluate the effectiveness of SFC in the treatment of penile AGW in immunocompeten...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Sociedade Brasileira de Dermatologia (SBD)
2025-03-01
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| Series: | Surgical & Cosmetic Dermatology |
| Subjects: | |
| Online Access: | http://www.surgicalcosmetic.org.br/Content/imagebank/pdf/v17/en_v17a334.pdf |
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| Summary: | Introduction: An 85% phenol and 4% croton oil solution (SFC) has cytotoxic effect on the epithelium;
however, it has not been evaluated in the treatment of anogenital warts (AGW).
Objective: To evaluate the effectiveness of SFC in the treatment of penile AGW in immunocompetent
patients.
Methods: Open, uncontrolled clinical trial (proof-of-concept), involving patients with penile AGW
treated with SFC and reevaluated after 28 days.
RESULTS: We evaluated 16 treatments in 9 participants. SFC promoted total clearance of the lesions in
25% (95% CI 2-48%) of treatments.
Conclusions: Although well tolerated, SFC caused insufficient rates of total clearance. |
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| ISSN: | 1984-8773 |