MergeReference: A Tool for Merging Reference Panels for HLA Imputation
Recently developed computational methods allow the imputation of human leukocyte antigen (HLA) genes using intergenic single nucleotide polymorphism markers. To improve the imputation accuracy in HLA imputation, it is essential to increase the sample size and the diversity of alleles in the referenc...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
BioMed Central
2017-09-01
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| Series: | Genomics & Informatics |
| Subjects: | |
| Online Access: | http://genominfo.org/upload/pdf/GI-2017-15-3-108.pdf |
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| Summary: | Recently developed computational methods allow the imputation of human leukocyte antigen (HLA) genes using intergenic single nucleotide polymorphism markers. To improve the imputation accuracy in HLA imputation, it is essential to increase the sample size and the diversity of alleles in the reference panel. Our software, MergeReference, helps achieve this goal by providing a streamlined pipeline for combining multiple reference panels into one. |
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| ISSN: | 2234-0742 |