Integrated machine learning and single-cell RNA sequencing reveal COL4A2 and CXCL6 as oxidative stress-associated biomarkers in periodontitis

Integrated machine learning and single-cell RNA sequencing reveal COL4A2 and CXCL6 as oxidative stress-associated biomarkers in periodontitis

BackgroundPeriodontitis, recognized as the second most prevalent oral disease globally, is strongly linked to systemic disorders like diabetes and cardiovascular diseases, highlighting the critical need for effective prevention and treatment strategies. Oxidative stress plays an important role in pe...

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Bibliographic Details
Main Authors: Siyu Sun, Jing Ren, Xiujuan Zeng, Yanbin Chen, Qianbing Zhou, Junying Yang, Shan Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Immunology
Subjects:
periodontitis
oxidative stress
single-cell RNA sequencing
COL4A2
CXCL6
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1598642/full
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