Autologous and Heterologous Minor and Major Bone Regeneration with Platelet-Derived Growth Factors
Aim: This review aims to explore the clinical applications, biological mechanisms, and potential benefits of concentrated growth factors (CGFs), autologous materials, and xenografts in bone regeneration, particularly in dental treatments such as alveolar ridge preservation, mandibular osteonecrosis,...
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MDPI AG
2025-01-01
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| Series: | Journal of Functional Biomaterials |
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| Online Access: | https://www.mdpi.com/2079-4983/16/1/16 |
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| author | Gianna Dipalma Angelo Michele Inchingolo Valeria Colonna Pierluigi Marotti Claudio Carone Laura Ferrante Francesco Inchingolo Andrea Palermo Alessio Danilo Inchingolo |
| author_facet | Gianna Dipalma Angelo Michele Inchingolo Valeria Colonna Pierluigi Marotti Claudio Carone Laura Ferrante Francesco Inchingolo Andrea Palermo Alessio Danilo Inchingolo |
| author_sort | Gianna Dipalma |
| collection | DOAJ |
| description | Aim: This review aims to explore the clinical applications, biological mechanisms, and potential benefits of concentrated growth factors (CGFs), autologous materials, and xenografts in bone regeneration, particularly in dental treatments such as alveolar ridge preservation, mandibular osteonecrosis, and peri-implantitis. Materials and Methods. A systematic literature search was conducted using databases like PubMed, Scopus, and Web of Science, with keywords such as “bone regeneration” and “CGF” from 2014 to 2024. Only English-language clinical studies involving human subjects were included. A total of 10 studies were selected for qualitative analysis. Data were processed through multiple stages, including title and abstract screening and full-text evaluation. Conclusion: The findings of the reviewed studies underscore the potential of the CGF in enhancing bone regeneration through stimulating cell proliferation, angiogenesis, and extracellular matrix mineralization. Autologous materials have also demonstrated promising results due to their biocompatibility and capacity for seamless integration with natural bone tissue. When combined with xenografts, these materials show synergistic effects in improving bone quantity and quality, which are crucial for dental implant success. Future research should focus on direct comparisons of different techniques, the optimization of protocols, and broader applications beyond dental medicine. The integration of CGFs and autologous materials into routine clinical practice represents a significant advancement in regenerative dental medicine, with the potential for improved patient outcomes and satisfaction. |
| format | Article |
| id | doaj-art-b8428573d4bb4601a4771c7b59b3a170 |
| institution | Kabale University |
| issn | 2079-4983 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Functional Biomaterials |
| spelling | doaj-art-b8428573d4bb4601a4771c7b59b3a1702025-01-24T13:36:07ZengMDPI AGJournal of Functional Biomaterials2079-49832025-01-011611610.3390/jfb16010016Autologous and Heterologous Minor and Major Bone Regeneration with Platelet-Derived Growth FactorsGianna Dipalma0Angelo Michele Inchingolo1Valeria Colonna2Pierluigi Marotti3Claudio Carone4Laura Ferrante5Francesco Inchingolo6Andrea Palermo7Alessio Danilo Inchingolo8Department of Interdisciplinary Medicine, University of Bari “Aldo Moro”, 70121 Bari, ItalyDepartment of Interdisciplinary Medicine, University of Bari “Aldo Moro”, 70121 Bari, ItalyDepartment of Interdisciplinary Medicine, University of Bari “Aldo Moro”, 70121 Bari, ItalyDepartment of Interdisciplinary Medicine, University of Bari “Aldo Moro”, 70121 Bari, ItalyDepartment of Interdisciplinary Medicine, University of Bari “Aldo Moro”, 70121 Bari, ItalyDepartment of Interdisciplinary Medicine, University of Bari “Aldo Moro”, 70121 Bari, ItalyDepartment of Interdisciplinary Medicine, University of Bari “Aldo Moro”, 70121 Bari, ItalyDepartment of Experimental Medicine, University of Salento, 73100 Lecce, ItalyDepartment of Interdisciplinary Medicine, University of Bari “Aldo Moro”, 70121 Bari, ItalyAim: This review aims to explore the clinical applications, biological mechanisms, and potential benefits of concentrated growth factors (CGFs), autologous materials, and xenografts in bone regeneration, particularly in dental treatments such as alveolar ridge preservation, mandibular osteonecrosis, and peri-implantitis. Materials and Methods. A systematic literature search was conducted using databases like PubMed, Scopus, and Web of Science, with keywords such as “bone regeneration” and “CGF” from 2014 to 2024. Only English-language clinical studies involving human subjects were included. A total of 10 studies were selected for qualitative analysis. Data were processed through multiple stages, including title and abstract screening and full-text evaluation. Conclusion: The findings of the reviewed studies underscore the potential of the CGF in enhancing bone regeneration through stimulating cell proliferation, angiogenesis, and extracellular matrix mineralization. Autologous materials have also demonstrated promising results due to their biocompatibility and capacity for seamless integration with natural bone tissue. When combined with xenografts, these materials show synergistic effects in improving bone quantity and quality, which are crucial for dental implant success. Future research should focus on direct comparisons of different techniques, the optimization of protocols, and broader applications beyond dental medicine. The integration of CGFs and autologous materials into routine clinical practice represents a significant advancement in regenerative dental medicine, with the potential for improved patient outcomes and satisfaction.https://www.mdpi.com/2079-4983/16/1/16minor bone regenerationmajor bone regenerationautologousheterologousgrowth factor |
| spellingShingle | Gianna Dipalma Angelo Michele Inchingolo Valeria Colonna Pierluigi Marotti Claudio Carone Laura Ferrante Francesco Inchingolo Andrea Palermo Alessio Danilo Inchingolo Autologous and Heterologous Minor and Major Bone Regeneration with Platelet-Derived Growth Factors Journal of Functional Biomaterials minor bone regeneration major bone regeneration autologous heterologous growth factor |
| title | Autologous and Heterologous Minor and Major Bone Regeneration with Platelet-Derived Growth Factors |
| title_full | Autologous and Heterologous Minor and Major Bone Regeneration with Platelet-Derived Growth Factors |
| title_fullStr | Autologous and Heterologous Minor and Major Bone Regeneration with Platelet-Derived Growth Factors |
| title_full_unstemmed | Autologous and Heterologous Minor and Major Bone Regeneration with Platelet-Derived Growth Factors |
| title_short | Autologous and Heterologous Minor and Major Bone Regeneration with Platelet-Derived Growth Factors |
| title_sort | autologous and heterologous minor and major bone regeneration with platelet derived growth factors |
| topic | minor bone regeneration major bone regeneration autologous heterologous growth factor |
| url | https://www.mdpi.com/2079-4983/16/1/16 |
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