Ocular and Mucocutaneous Sequelae among Survivors of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in Togo
Aim. The aim of this study was to assess ocular and mucocutaneous sequelae among SJS/TEN survivors and identify risk factors of ocular sequelae. Patients and Method. Late complications among SJS/TEN survivors were assessed using 2 methods: a retrospective assessment of medical records only or a retr...
Saved in:
| Main Authors: | , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2019-01-01
|
| Series: | Dermatology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2019/4917024 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832560758515302400 |
|---|---|
| author | Bayaki Saka Abla Séfako Akakpo Julienne Noude Teclessou Garba Mahamadou Abas Mouhari-Toure Kossi Dzidzinyo Adam Nouhou Diori Nidain Maneh Sabin Prince-Agbodjan Koussake Kombaté Komi Balo Kissem Tchangai-Walla Palokinam Pitché |
| author_facet | Bayaki Saka Abla Séfako Akakpo Julienne Noude Teclessou Garba Mahamadou Abas Mouhari-Toure Kossi Dzidzinyo Adam Nouhou Diori Nidain Maneh Sabin Prince-Agbodjan Koussake Kombaté Komi Balo Kissem Tchangai-Walla Palokinam Pitché |
| author_sort | Bayaki Saka |
| collection | DOAJ |
| description | Aim. The aim of this study was to assess ocular and mucocutaneous sequelae among SJS/TEN survivors and identify risk factors of ocular sequelae. Patients and Method. Late complications among SJS/TEN survivors were assessed using 2 methods: a retrospective assessment of medical records only or a retrospective assessment of medical records and physical examination of survivors who were contacted by phone. Results. Between January 1995 and December 2017, 177 cases of SJS/TEN (138 cases of SJS, 29 cases of TEN, and 10 cases SJS/TEN overlap) were admitted into two university hospitals of Lomé (Togo). There were 113 women and 64 men, with an average age of 31.7±13.0 years (range: 5 to 80 years). The most used drugs were antibacterial sulfonamides (35.6%) and nevirapine (24.3%). HIV serology was positive in 68 (59.1%) of the 115 patients tested. Sixty-four (52,5%) of the 122 patients, who had been examined by an ophthalmologist during the acute stage, had acute ocular involvement, which was mild in 27.9% of patients, moderate in 13.1%, and severe in 11.5%. We recorded 17 deaths (i.e., three cases of SJS, 12 of TEN, and two of SJS/TEN overlap), including 11 cases of HIV infected patients. Of the 160 SJS/TEN survivors, only 71 patients were assessed 6 months after hospital discharge. Among them, forty-three (60.6%) patients had sequelae. Concerning mucocutaneous sequelae, the main lesions were diffuse dyschromic macules (38.0% of patients) and ocular sequelae were dominated by decreased visual acuity (14.1% of patients). In multivariate analysis, exposure to sulfadoxine (odds adjusted ratio = 5.95; 95%CI= [1.36-31.35]) and moderate (adjusted odds ratio = 5.85; 95%CI = [1.23-31.81]) or severe (adjusted odds ratio = 48.30; 95%CI = [6.25-1063.66]) ocular involvement at acute stage were associated with ocular sequelae. Conclusion. Ocular and mucocutaneous sequelae are common in SJS/TEN survivors. Exposure to sulfadoxine and severity of acute ocular involvement are risk factors of ocular sequelae. |
| format | Article |
| id | doaj-art-b83234245e314f36a70bcc69e0028495 |
| institution | Kabale University |
| issn | 1687-6105 1687-6113 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Dermatology Research and Practice |
| spelling | doaj-art-b83234245e314f36a70bcc69e00284952025-02-03T01:26:53ZengWileyDermatology Research and Practice1687-61051687-61132019-01-01201910.1155/2019/49170244917024Ocular and Mucocutaneous Sequelae among Survivors of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in TogoBayaki Saka0Abla Séfako Akakpo1Julienne Noude Teclessou2Garba Mahamadou3Abas Mouhari-Toure4Kossi Dzidzinyo5Adam Nouhou Diori6Nidain Maneh7Sabin Prince-Agbodjan8Koussake Kombaté9Komi Balo10Kissem Tchangai-Walla11Palokinam Pitché12Dermatology Unit, Sylvanus Olympio Teaching Hospital, University of Lomé, TogoDermatology Unit, Sylvanus Olympio Teaching Hospital, University of Lomé, TogoDermatology Unit, Campus Teaching Hospital, University of Lomé, TogoDermatology Unit, Sylvanus Olympio Teaching Hospital, University of Lomé, TogoDermatology Unit, Kara Teaching Hospital, University of Kara Ophthalmology, TogoDermatology Unit, Sylvanus Olympio Teaching Hospital, University of Lomé, TogoDermatology Unit, Sylvanus Olympio Teaching Hospital, University of Lomé, TogoOphthalmology Unit, Campus Teaching Hospital, University of Lomé, TogoDermatology Unit, Sylvanus Olympio Teaching Hospital, University of Lomé, TogoDermatology Unit, Campus Teaching Hospital, University of Lomé, TogoDermatology Unit, Sylvanus Olympio Teaching Hospital, University of Lomé, TogoDermatology Unit, Sylvanus Olympio Teaching Hospital, University of Lomé, TogoDermatology Unit, Sylvanus Olympio Teaching Hospital, University of Lomé, TogoAim. The aim of this study was to assess ocular and mucocutaneous sequelae among SJS/TEN survivors and identify risk factors of ocular sequelae. Patients and Method. Late complications among SJS/TEN survivors were assessed using 2 methods: a retrospective assessment of medical records only or a retrospective assessment of medical records and physical examination of survivors who were contacted by phone. Results. Between January 1995 and December 2017, 177 cases of SJS/TEN (138 cases of SJS, 29 cases of TEN, and 10 cases SJS/TEN overlap) were admitted into two university hospitals of Lomé (Togo). There were 113 women and 64 men, with an average age of 31.7±13.0 years (range: 5 to 80 years). The most used drugs were antibacterial sulfonamides (35.6%) and nevirapine (24.3%). HIV serology was positive in 68 (59.1%) of the 115 patients tested. Sixty-four (52,5%) of the 122 patients, who had been examined by an ophthalmologist during the acute stage, had acute ocular involvement, which was mild in 27.9% of patients, moderate in 13.1%, and severe in 11.5%. We recorded 17 deaths (i.e., three cases of SJS, 12 of TEN, and two of SJS/TEN overlap), including 11 cases of HIV infected patients. Of the 160 SJS/TEN survivors, only 71 patients were assessed 6 months after hospital discharge. Among them, forty-three (60.6%) patients had sequelae. Concerning mucocutaneous sequelae, the main lesions were diffuse dyschromic macules (38.0% of patients) and ocular sequelae were dominated by decreased visual acuity (14.1% of patients). In multivariate analysis, exposure to sulfadoxine (odds adjusted ratio = 5.95; 95%CI= [1.36-31.35]) and moderate (adjusted odds ratio = 5.85; 95%CI = [1.23-31.81]) or severe (adjusted odds ratio = 48.30; 95%CI = [6.25-1063.66]) ocular involvement at acute stage were associated with ocular sequelae. Conclusion. Ocular and mucocutaneous sequelae are common in SJS/TEN survivors. Exposure to sulfadoxine and severity of acute ocular involvement are risk factors of ocular sequelae.http://dx.doi.org/10.1155/2019/4917024 |
| spellingShingle | Bayaki Saka Abla Séfako Akakpo Julienne Noude Teclessou Garba Mahamadou Abas Mouhari-Toure Kossi Dzidzinyo Adam Nouhou Diori Nidain Maneh Sabin Prince-Agbodjan Koussake Kombaté Komi Balo Kissem Tchangai-Walla Palokinam Pitché Ocular and Mucocutaneous Sequelae among Survivors of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in Togo Dermatology Research and Practice |
| title | Ocular and Mucocutaneous Sequelae among Survivors of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in Togo |
| title_full | Ocular and Mucocutaneous Sequelae among Survivors of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in Togo |
| title_fullStr | Ocular and Mucocutaneous Sequelae among Survivors of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in Togo |
| title_full_unstemmed | Ocular and Mucocutaneous Sequelae among Survivors of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in Togo |
| title_short | Ocular and Mucocutaneous Sequelae among Survivors of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in Togo |
| title_sort | ocular and mucocutaneous sequelae among survivors of stevens johnson syndrome and toxic epidermal necrolysis in togo |
| url | http://dx.doi.org/10.1155/2019/4917024 |
| work_keys_str_mv | AT bayakisaka ocularandmucocutaneoussequelaeamongsurvivorsofstevensjohnsonsyndromeandtoxicepidermalnecrolysisintogo AT ablasefakoakakpo ocularandmucocutaneoussequelaeamongsurvivorsofstevensjohnsonsyndromeandtoxicepidermalnecrolysisintogo AT juliennenoudeteclessou ocularandmucocutaneoussequelaeamongsurvivorsofstevensjohnsonsyndromeandtoxicepidermalnecrolysisintogo AT garbamahamadou ocularandmucocutaneoussequelaeamongsurvivorsofstevensjohnsonsyndromeandtoxicepidermalnecrolysisintogo AT abasmouharitoure ocularandmucocutaneoussequelaeamongsurvivorsofstevensjohnsonsyndromeandtoxicepidermalnecrolysisintogo AT kossidzidzinyo ocularandmucocutaneoussequelaeamongsurvivorsofstevensjohnsonsyndromeandtoxicepidermalnecrolysisintogo AT adamnouhoudiori ocularandmucocutaneoussequelaeamongsurvivorsofstevensjohnsonsyndromeandtoxicepidermalnecrolysisintogo AT nidainmaneh ocularandmucocutaneoussequelaeamongsurvivorsofstevensjohnsonsyndromeandtoxicepidermalnecrolysisintogo AT sabinprinceagbodjan ocularandmucocutaneoussequelaeamongsurvivorsofstevensjohnsonsyndromeandtoxicepidermalnecrolysisintogo AT koussakekombate ocularandmucocutaneoussequelaeamongsurvivorsofstevensjohnsonsyndromeandtoxicepidermalnecrolysisintogo AT komibalo ocularandmucocutaneoussequelaeamongsurvivorsofstevensjohnsonsyndromeandtoxicepidermalnecrolysisintogo AT kissemtchangaiwalla ocularandmucocutaneoussequelaeamongsurvivorsofstevensjohnsonsyndromeandtoxicepidermalnecrolysisintogo AT palokinampitche ocularandmucocutaneoussequelaeamongsurvivorsofstevensjohnsonsyndromeandtoxicepidermalnecrolysisintogo |