Comparison of properties of HAp and CaTiO3-HAp ceramic composite fabricated by different sintering conditions
A hydroxyapatite (HAp) ceramic and a 20 wt% CaTiO3-HAp ceramic composite for potential application as biomaterials were produced using single-step sintering (SS) and twostep sintering (TSS) in air. The sample pellets were SS sintered at 1250°C with a holding time of 1 h. For TSS, the pellets were he...
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International Institute for the Science of Sintering, Beograd
2024-01-01
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| Series: | Science of Sintering |
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| Online Access: | https://doiserbia.nb.rs/img/doi/0350-820X/2024/0350-820X2400019C.pdf |
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| author | Chiengsorn Rawisada Lioroongcharoen Supimkarn Charoenpanich Adisri Chanadee Tawat |
| author_facet | Chiengsorn Rawisada Lioroongcharoen Supimkarn Charoenpanich Adisri Chanadee Tawat |
| author_sort | Chiengsorn Rawisada |
| collection | DOAJ |
| description | A hydroxyapatite (HAp) ceramic and a 20 wt% CaTiO3-HAp ceramic composite for potential application as biomaterials were produced using single-step sintering (SS) and twostep sintering (TSS) in air. The sample pellets were SS sintered at 1250°C with a holding time of 1 h. For TSS, the pellets were heated at 10°C/min to 1250°C (T1) and held at this temperature for 20 min (t1). The temperature was then rapidly lowered at 20°C/min to 1150°C (T2), and held at this temperature for 10 min (t2). The 20 wt% CaTiO3-HAp ceramic composite obtained from TSS had a fine grain of 0.56 ± 0.04 μm due to the restraint of grain growth caused by the fast cooling from T1 to T2 and the hard CaTiO3 particles dispersed in the HAp matrix. The microstructure refinement of the 20 wt% CaTiO3-HAp ceramic composite fabricated by TSS produced suitable sintered density due to increased locking at triple junctions. This ceramic composite exhibited fracture toughness of 2.10 MPa.m1/2 with brittleness of 1.97 mm-1/2, indicating that crack propagation was suppressed. MG-63 osteoblast cells were able to adhere to the surface of both HAp and the 20 wt% CaTiO3-HAp ceramic composite produced by TSS and were no different between 3 and 7 days of culture. The alkaline phosphatase activity of MG-63 cells was higher on both ceramics cultured in osteogenic differentiation medium than in complete growth medium, which indicated more efficient osteoinductivity. |
| format | Article |
| id | doaj-art-b83200b41ef24e06900e2aafb111c441 |
| institution | Kabale University |
| issn | 0350-820X 1820-7413 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | International Institute for the Science of Sintering, Beograd |
| record_format | Article |
| series | Science of Sintering |
| spelling | doaj-art-b83200b41ef24e06900e2aafb111c4412025-01-30T06:46:26ZengInternational Institute for the Science of Sintering, BeogradScience of Sintering0350-820X1820-74132024-01-0156451953310.2298/SOS240321019C0350-820X2400019CComparison of properties of HAp and CaTiO3-HAp ceramic composite fabricated by different sintering conditionsChiengsorn Rawisada0Lioroongcharoen Supimkarn1Charoenpanich Adisri2Chanadee Tawat3PSU. Wittayanusorn School, Hat Yai, Songkhla, ThailandPSU. Wittayanusorn School, Hat Yai, Songkhla, ThailandDepartment of Biology, Faculty of Science, Silpakorn University, Mueang, Nakhon Pathom, ThailandMaterials Science Program, Division of Physical Science, Faculty of Science, Prince of Songkla University (PSU), Hat Yai, Songkhla, ThailandA hydroxyapatite (HAp) ceramic and a 20 wt% CaTiO3-HAp ceramic composite for potential application as biomaterials were produced using single-step sintering (SS) and twostep sintering (TSS) in air. The sample pellets were SS sintered at 1250°C with a holding time of 1 h. For TSS, the pellets were heated at 10°C/min to 1250°C (T1) and held at this temperature for 20 min (t1). The temperature was then rapidly lowered at 20°C/min to 1150°C (T2), and held at this temperature for 10 min (t2). The 20 wt% CaTiO3-HAp ceramic composite obtained from TSS had a fine grain of 0.56 ± 0.04 μm due to the restraint of grain growth caused by the fast cooling from T1 to T2 and the hard CaTiO3 particles dispersed in the HAp matrix. The microstructure refinement of the 20 wt% CaTiO3-HAp ceramic composite fabricated by TSS produced suitable sintered density due to increased locking at triple junctions. This ceramic composite exhibited fracture toughness of 2.10 MPa.m1/2 with brittleness of 1.97 mm-1/2, indicating that crack propagation was suppressed. MG-63 osteoblast cells were able to adhere to the surface of both HAp and the 20 wt% CaTiO3-HAp ceramic composite produced by TSS and were no different between 3 and 7 days of culture. The alkaline phosphatase activity of MG-63 cells was higher on both ceramics cultured in osteogenic differentiation medium than in complete growth medium, which indicated more efficient osteoinductivity.https://doiserbia.nb.rs/img/doi/0350-820X/2024/0350-820X2400019C.pdfcatio3hapbioceramicstwo-step sinteringosteoblast |
| spellingShingle | Chiengsorn Rawisada Lioroongcharoen Supimkarn Charoenpanich Adisri Chanadee Tawat Comparison of properties of HAp and CaTiO3-HAp ceramic composite fabricated by different sintering conditions Science of Sintering catio3 hap bioceramics two-step sintering osteoblast |
| title | Comparison of properties of HAp and CaTiO3-HAp ceramic composite fabricated by different sintering conditions |
| title_full | Comparison of properties of HAp and CaTiO3-HAp ceramic composite fabricated by different sintering conditions |
| title_fullStr | Comparison of properties of HAp and CaTiO3-HAp ceramic composite fabricated by different sintering conditions |
| title_full_unstemmed | Comparison of properties of HAp and CaTiO3-HAp ceramic composite fabricated by different sintering conditions |
| title_short | Comparison of properties of HAp and CaTiO3-HAp ceramic composite fabricated by different sintering conditions |
| title_sort | comparison of properties of hap and catio3 hap ceramic composite fabricated by different sintering conditions |
| topic | catio3 hap bioceramics two-step sintering osteoblast |
| url | https://doiserbia.nb.rs/img/doi/0350-820X/2024/0350-820X2400019C.pdf |
| work_keys_str_mv | AT chiengsornrawisada comparisonofpropertiesofhapandcatio3hapceramiccompositefabricatedbydifferentsinteringconditions AT lioroongcharoensupimkarn comparisonofpropertiesofhapandcatio3hapceramiccompositefabricatedbydifferentsinteringconditions AT charoenpanichadisri comparisonofpropertiesofhapandcatio3hapceramiccompositefabricatedbydifferentsinteringconditions AT chanadeetawat comparisonofpropertiesofhapandcatio3hapceramiccompositefabricatedbydifferentsinteringconditions |