Optimizing the dose-averaged linear energy transfer for the dominant intraprostatic lesions in high-risk localized prostate cancer patients

Optimizing the dose-averaged linear energy transfer for the dominant intraprostatic lesions in high-risk localized prostate cancer patients

Background and purpose: Radiotherapy for localized prostate cancer often targets the entire prostate with a uniform dose despite the presence of high-risk dominant intraprostatic lesions (DILs). This study investigated the feasibility of focal dose-averaged linear energy transfer (LETd) boost for pr...

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Bibliographic Details
Main Authors: Bo Zhao, Nobuyuki Kanematsu, Shuri Aoki, Shinichiro Mori, Hideyuki Mizuno, Takamitsu Masuda, Hideyuki Takei, Hitoshi Ishikawa
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:Physics and Imaging in Radiation Oncology
Subjects:
Localized prostate cancer
Carbon-ion radiotherapy
LET painting
Dose-averaged LET
Focal boost
Online Access:http://www.sciencedirect.com/science/article/pii/S2405631625000326
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