Enhanced spatial analysis assessing the association between PFAS-contaminated water and cancer incidence: rationale, study design, and methods
Abstract Background Cancer is a complex set of diseases, and many have decades-long lag times between possible exposure and diagnosis. Environmental exposures, such as per- and poly-fluoroalkyl substances (PFAS) and area-level risk factors (e.g., socioeconomic variables), vary for people over time a...
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| Format: | Article |
| Language: | English |
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BMC
2025-01-01
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| Series: | BMC Cancer |
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| Online Access: | https://doi.org/10.1186/s12885-025-13508-2 |
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| author | Resa M. Jones Erin R. Kulick Ryan Snead Robin Taylor Wilson John Hughes Ted Lillys |
| author_facet | Resa M. Jones Erin R. Kulick Ryan Snead Robin Taylor Wilson John Hughes Ted Lillys |
| author_sort | Resa M. Jones |
| collection | DOAJ |
| description | Abstract Background Cancer is a complex set of diseases, and many have decades-long lag times between possible exposure and diagnosis. Environmental exposures, such as per- and poly-fluoroalkyl substances (PFAS) and area-level risk factors (e.g., socioeconomic variables), vary for people over time and space. Evidence suggests PFAS exposure is associated with several cancers; however, studies to date have various limitations. Few studies have used rigorous spatiotemporal approaches, and, to our knowledge, none have assessed cumulative exposures given residential histories or incorporated chemical mixture modeling. Thus, spatiotemporal analysis using advanced statistical approaches, accounting for spatially structured and unstructured heterogeneity in risk, can be a highly informative strategy for addressing the potential health effects of PFAS exposure. Methods Using population-based incident cancer cases and cancer-free controls in a 12-county area of southeastern Pennsylvania, we will apply Bayesian spatiotemporal analysis methods using historically reconstructed PFAS-contaminated water exposure given residential histories, and other potential cancer determinants over time. Bayesian group index models enable assessment of various mixtures of highly correlated PFAS chemical exposures incorporating mobility/residential history, and contextual factors to determine the association of PFAS-related exposures and cancer incidence. Discussion The purpose of this paper is to describe the Enhanced PFAS Spatial Analysis study rationale, study design, and methods. |
| format | Article |
| id | doaj-art-b8236a53832a49719b180c487d5c64c1 |
| institution | Kabale University |
| issn | 1471-2407 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cancer |
| spelling | doaj-art-b8236a53832a49719b180c487d5c64c12025-01-26T12:38:11ZengBMCBMC Cancer1471-24072025-01-0125111110.1186/s12885-025-13508-2Enhanced spatial analysis assessing the association between PFAS-contaminated water and cancer incidence: rationale, study design, and methodsResa M. Jones0Erin R. Kulick1Ryan Snead2Robin Taylor Wilson3John Hughes4Ted Lillys5Department of Epidemiology and Biostatistics, College of Public Health, Temple UniversityDepartment of Epidemiology and Biostatistics, College of Public Health, Temple UniversityDepartment of Epidemiology and Biostatistics, College of Public Health, Temple UniversityDepartment of Epidemiology and Biostatistics, College of Public Health, Temple UniversityDepartment of Community and Population Health, College of Health, Lehigh UniversityResearch Triangle InstituteAbstract Background Cancer is a complex set of diseases, and many have decades-long lag times between possible exposure and diagnosis. Environmental exposures, such as per- and poly-fluoroalkyl substances (PFAS) and area-level risk factors (e.g., socioeconomic variables), vary for people over time and space. Evidence suggests PFAS exposure is associated with several cancers; however, studies to date have various limitations. Few studies have used rigorous spatiotemporal approaches, and, to our knowledge, none have assessed cumulative exposures given residential histories or incorporated chemical mixture modeling. Thus, spatiotemporal analysis using advanced statistical approaches, accounting for spatially structured and unstructured heterogeneity in risk, can be a highly informative strategy for addressing the potential health effects of PFAS exposure. Methods Using population-based incident cancer cases and cancer-free controls in a 12-county area of southeastern Pennsylvania, we will apply Bayesian spatiotemporal analysis methods using historically reconstructed PFAS-contaminated water exposure given residential histories, and other potential cancer determinants over time. Bayesian group index models enable assessment of various mixtures of highly correlated PFAS chemical exposures incorporating mobility/residential history, and contextual factors to determine the association of PFAS-related exposures and cancer incidence. Discussion The purpose of this paper is to describe the Enhanced PFAS Spatial Analysis study rationale, study design, and methods.https://doi.org/10.1186/s12885-025-13508-2BayesianCancer incidenceIndex modelPFASResidential historySpatiotemporal |
| spellingShingle | Resa M. Jones Erin R. Kulick Ryan Snead Robin Taylor Wilson John Hughes Ted Lillys Enhanced spatial analysis assessing the association between PFAS-contaminated water and cancer incidence: rationale, study design, and methods BMC Cancer Bayesian Cancer incidence Index model PFAS Residential history Spatiotemporal |
| title | Enhanced spatial analysis assessing the association between PFAS-contaminated water and cancer incidence: rationale, study design, and methods |
| title_full | Enhanced spatial analysis assessing the association between PFAS-contaminated water and cancer incidence: rationale, study design, and methods |
| title_fullStr | Enhanced spatial analysis assessing the association between PFAS-contaminated water and cancer incidence: rationale, study design, and methods |
| title_full_unstemmed | Enhanced spatial analysis assessing the association between PFAS-contaminated water and cancer incidence: rationale, study design, and methods |
| title_short | Enhanced spatial analysis assessing the association between PFAS-contaminated water and cancer incidence: rationale, study design, and methods |
| title_sort | enhanced spatial analysis assessing the association between pfas contaminated water and cancer incidence rationale study design and methods |
| topic | Bayesian Cancer incidence Index model PFAS Residential history Spatiotemporal |
| url | https://doi.org/10.1186/s12885-025-13508-2 |
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