The Prognostic Impact of Protein Expression of E-Cadherin-Catenin Complexes Differs between Rectal and Colon Carcinoma
The E-cadherin-catenin complex provides cell-cell adhesion. In order for a carcinoma to metastasize, cancer cells must let go of their hold of neighboring cells in the primary tumor. The presence of components of the E-cadherin-catenin complex in 246 rectal adenocarcinomas was examined by immunohist...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2010/616023 |
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| author | Rolf Aamodt Johan Bondi Solveig Norheim Andersen Arne Bakka Geir Bukholm Ida R. K. Bukholm |
| author_facet | Rolf Aamodt Johan Bondi Solveig Norheim Andersen Arne Bakka Geir Bukholm Ida R. K. Bukholm |
| author_sort | Rolf Aamodt |
| collection | DOAJ |
| description | The E-cadherin-catenin complex provides cell-cell adhesion. In order for a carcinoma to metastasize, cancer cells must let go of their hold of neighboring cells in the primary tumor. The presence of components of the E-cadherin-catenin complex in 246 rectal adenocarcinomas was examined by immunohistochemistry and compared to their presence in 219 colon carcinomas. The expression data were correlated to clinical information from the patients' records. There were statistically significant differences in protein expression between the rectal and the colon carcinomas regarding membranous 𝛽-catenin, 𝛾-catenin, p120-catenin, and E-cadherin, as well as nuclear 𝛽-catenin. In the rectal carcinomas, there was a significant inverse association between the expression of p120-catenin in cell membranes of the primary tumors and the occurrence of local recurrence, while membranous protein expression of 𝛽-catenin was inversely related to distant metastases. |
| format | Article |
| id | doaj-art-b8106576e9164153b97e010bc6ffc8a4 |
| institution | Kabale University |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-b8106576e9164153b97e010bc6ffc8a42025-02-03T01:23:19ZengWileyGastroenterology Research and Practice1687-61211687-630X2010-01-01201010.1155/2010/616023616023The Prognostic Impact of Protein Expression of E-Cadherin-Catenin Complexes Differs between Rectal and Colon CarcinomaRolf Aamodt0Johan Bondi1Solveig Norheim Andersen2Arne Bakka3Geir Bukholm4Ida R. K. Bukholm5Faculty Division Akershus University Hospital, University of Oslo, 1474 Nordbyhagen, NorwayDepartment of Digestive Surgery, Akershus University Hospital, 1478 Loerenskog, NorwayFaculty Division Akershus University Hospital, University of Oslo, 1474 Nordbyhagen, NorwayFaculty Division Akershus University Hospital, University of Oslo, 1474 Nordbyhagen, NorwayInstitute of Health and Society, University of Oslo, Forskningsveien 3A, 0373 Oslo, NorwayFaculty Division Akershus University Hospital, University of Oslo, 1474 Nordbyhagen, NorwayThe E-cadherin-catenin complex provides cell-cell adhesion. In order for a carcinoma to metastasize, cancer cells must let go of their hold of neighboring cells in the primary tumor. The presence of components of the E-cadherin-catenin complex in 246 rectal adenocarcinomas was examined by immunohistochemistry and compared to their presence in 219 colon carcinomas. The expression data were correlated to clinical information from the patients' records. There were statistically significant differences in protein expression between the rectal and the colon carcinomas regarding membranous 𝛽-catenin, 𝛾-catenin, p120-catenin, and E-cadherin, as well as nuclear 𝛽-catenin. In the rectal carcinomas, there was a significant inverse association between the expression of p120-catenin in cell membranes of the primary tumors and the occurrence of local recurrence, while membranous protein expression of 𝛽-catenin was inversely related to distant metastases.http://dx.doi.org/10.1155/2010/616023 |
| spellingShingle | Rolf Aamodt Johan Bondi Solveig Norheim Andersen Arne Bakka Geir Bukholm Ida R. K. Bukholm The Prognostic Impact of Protein Expression of E-Cadherin-Catenin Complexes Differs between Rectal and Colon Carcinoma Gastroenterology Research and Practice |
| title | The Prognostic Impact of Protein Expression of E-Cadherin-Catenin Complexes Differs between Rectal and Colon Carcinoma |
| title_full | The Prognostic Impact of Protein Expression of E-Cadherin-Catenin Complexes Differs between Rectal and Colon Carcinoma |
| title_fullStr | The Prognostic Impact of Protein Expression of E-Cadherin-Catenin Complexes Differs between Rectal and Colon Carcinoma |
| title_full_unstemmed | The Prognostic Impact of Protein Expression of E-Cadherin-Catenin Complexes Differs between Rectal and Colon Carcinoma |
| title_short | The Prognostic Impact of Protein Expression of E-Cadherin-Catenin Complexes Differs between Rectal and Colon Carcinoma |
| title_sort | prognostic impact of protein expression of e cadherin catenin complexes differs between rectal and colon carcinoma |
| url | http://dx.doi.org/10.1155/2010/616023 |
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