Skull Impact on Photoacoustic Imaging of Multi-Layered Brain Tissues with Embedded Blood Vessel Under Different Optical Source Types: Modeling and Simulation

Skulls with high optical scattering and acoustic attenuation are a great challenge for photoacoustic imaging for human beings. To explore and improve photoacoustic generation and propagation, we conducted the photoacoustic simulation and image reconstruction of the multi-layer brain model with an em...

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Main Authors: Xi Yang, Chengpeng Chai, Yun-Hsuan Chen, Mohamad Sawan
Format: Article
Language:English
Published: MDPI AG 2025-01-01
Series:Bioengineering
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Online Access:https://www.mdpi.com/2306-5354/12/1/40
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author Xi Yang
Chengpeng Chai
Yun-Hsuan Chen
Mohamad Sawan
author_facet Xi Yang
Chengpeng Chai
Yun-Hsuan Chen
Mohamad Sawan
author_sort Xi Yang
collection DOAJ
description Skulls with high optical scattering and acoustic attenuation are a great challenge for photoacoustic imaging for human beings. To explore and improve photoacoustic generation and propagation, we conducted the photoacoustic simulation and image reconstruction of the multi-layer brain model with an embedded blood vessel under different optical source types. Based on the optical simulation results under different types of optical sources, we explored the characteristics of reconstructed images obtained from acoustic simulations with and without skull conditions. Specifically, we focused on the detection of blood vessels and evaluated the image reconstruction features, morphological characteristics, and intensity of variations in the target vessels using optical and acoustic simulations. The results showed that under the initial PA signals, the types of optical source types corresponding to the strongest and weakest photoacoustic signals at different positions within the target region were consistent, while the optical source types were different in the reconstructed images. This study revealed the characteristics of acoustic signal transmission with and without skull conditions and its impact on image reconstruction. It further provides a theoretical basis for the selection of optical sources.
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id doaj-art-b80b22ae70504e1d8f1a21b3ab11c76b
institution Kabale University
issn 2306-5354
language English
publishDate 2025-01-01
publisher MDPI AG
record_format Article
series Bioengineering
spelling doaj-art-b80b22ae70504e1d8f1a21b3ab11c76b2025-01-24T13:23:03ZengMDPI AGBioengineering2306-53542025-01-011214010.3390/bioengineering12010040Skull Impact on Photoacoustic Imaging of Multi-Layered Brain Tissues with Embedded Blood Vessel Under Different Optical Source Types: Modeling and SimulationXi Yang0Chengpeng Chai1Yun-Hsuan Chen2Mohamad Sawan3CenBRAIN Neurotech Center of Excellence, School of Engineering, Westlake University, Hangzhou 310030, ChinaCenBRAIN Neurotech Center of Excellence, School of Engineering, Westlake University, Hangzhou 310030, ChinaCenBRAIN Neurotech Center of Excellence, School of Engineering, Westlake University, Hangzhou 310030, ChinaCenBRAIN Neurotech Center of Excellence, School of Engineering, Westlake University, Hangzhou 310030, ChinaSkulls with high optical scattering and acoustic attenuation are a great challenge for photoacoustic imaging for human beings. To explore and improve photoacoustic generation and propagation, we conducted the photoacoustic simulation and image reconstruction of the multi-layer brain model with an embedded blood vessel under different optical source types. Based on the optical simulation results under different types of optical sources, we explored the characteristics of reconstructed images obtained from acoustic simulations with and without skull conditions. Specifically, we focused on the detection of blood vessels and evaluated the image reconstruction features, morphological characteristics, and intensity of variations in the target vessels using optical and acoustic simulations. The results showed that under the initial PA signals, the types of optical source types corresponding to the strongest and weakest photoacoustic signals at different positions within the target region were consistent, while the optical source types were different in the reconstructed images. This study revealed the characteristics of acoustic signal transmission with and without skull conditions and its impact on image reconstruction. It further provides a theoretical basis for the selection of optical sources.https://www.mdpi.com/2306-5354/12/1/40brain imagingoptical simulationMonte Carlo simulationacoustic simulationk-waveskull
spellingShingle Xi Yang
Chengpeng Chai
Yun-Hsuan Chen
Mohamad Sawan
Skull Impact on Photoacoustic Imaging of Multi-Layered Brain Tissues with Embedded Blood Vessel Under Different Optical Source Types: Modeling and Simulation
Bioengineering
brain imaging
optical simulation
Monte Carlo simulation
acoustic simulation
k-wave
skull
title Skull Impact on Photoacoustic Imaging of Multi-Layered Brain Tissues with Embedded Blood Vessel Under Different Optical Source Types: Modeling and Simulation
title_full Skull Impact on Photoacoustic Imaging of Multi-Layered Brain Tissues with Embedded Blood Vessel Under Different Optical Source Types: Modeling and Simulation
title_fullStr Skull Impact on Photoacoustic Imaging of Multi-Layered Brain Tissues with Embedded Blood Vessel Under Different Optical Source Types: Modeling and Simulation
title_full_unstemmed Skull Impact on Photoacoustic Imaging of Multi-Layered Brain Tissues with Embedded Blood Vessel Under Different Optical Source Types: Modeling and Simulation
title_short Skull Impact on Photoacoustic Imaging of Multi-Layered Brain Tissues with Embedded Blood Vessel Under Different Optical Source Types: Modeling and Simulation
title_sort skull impact on photoacoustic imaging of multi layered brain tissues with embedded blood vessel under different optical source types modeling and simulation
topic brain imaging
optical simulation
Monte Carlo simulation
acoustic simulation
k-wave
skull
url https://www.mdpi.com/2306-5354/12/1/40
work_keys_str_mv AT xiyang skullimpactonphotoacousticimagingofmultilayeredbraintissueswithembeddedbloodvesselunderdifferentopticalsourcetypesmodelingandsimulation
AT chengpengchai skullimpactonphotoacousticimagingofmultilayeredbraintissueswithembeddedbloodvesselunderdifferentopticalsourcetypesmodelingandsimulation
AT yunhsuanchen skullimpactonphotoacousticimagingofmultilayeredbraintissueswithembeddedbloodvesselunderdifferentopticalsourcetypesmodelingandsimulation
AT mohamadsawan skullimpactonphotoacousticimagingofmultilayeredbraintissueswithembeddedbloodvesselunderdifferentopticalsourcetypesmodelingandsimulation