Skull Impact on Photoacoustic Imaging of Multi-Layered Brain Tissues with Embedded Blood Vessel Under Different Optical Source Types: Modeling and Simulation
Skulls with high optical scattering and acoustic attenuation are a great challenge for photoacoustic imaging for human beings. To explore and improve photoacoustic generation and propagation, we conducted the photoacoustic simulation and image reconstruction of the multi-layer brain model with an em...
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MDPI AG
2025-01-01
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author | Xi Yang Chengpeng Chai Yun-Hsuan Chen Mohamad Sawan |
author_facet | Xi Yang Chengpeng Chai Yun-Hsuan Chen Mohamad Sawan |
author_sort | Xi Yang |
collection | DOAJ |
description | Skulls with high optical scattering and acoustic attenuation are a great challenge for photoacoustic imaging for human beings. To explore and improve photoacoustic generation and propagation, we conducted the photoacoustic simulation and image reconstruction of the multi-layer brain model with an embedded blood vessel under different optical source types. Based on the optical simulation results under different types of optical sources, we explored the characteristics of reconstructed images obtained from acoustic simulations with and without skull conditions. Specifically, we focused on the detection of blood vessels and evaluated the image reconstruction features, morphological characteristics, and intensity of variations in the target vessels using optical and acoustic simulations. The results showed that under the initial PA signals, the types of optical source types corresponding to the strongest and weakest photoacoustic signals at different positions within the target region were consistent, while the optical source types were different in the reconstructed images. This study revealed the characteristics of acoustic signal transmission with and without skull conditions and its impact on image reconstruction. It further provides a theoretical basis for the selection of optical sources. |
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id | doaj-art-b80b22ae70504e1d8f1a21b3ab11c76b |
institution | Kabale University |
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language | English |
publishDate | 2025-01-01 |
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series | Bioengineering |
spelling | doaj-art-b80b22ae70504e1d8f1a21b3ab11c76b2025-01-24T13:23:03ZengMDPI AGBioengineering2306-53542025-01-011214010.3390/bioengineering12010040Skull Impact on Photoacoustic Imaging of Multi-Layered Brain Tissues with Embedded Blood Vessel Under Different Optical Source Types: Modeling and SimulationXi Yang0Chengpeng Chai1Yun-Hsuan Chen2Mohamad Sawan3CenBRAIN Neurotech Center of Excellence, School of Engineering, Westlake University, Hangzhou 310030, ChinaCenBRAIN Neurotech Center of Excellence, School of Engineering, Westlake University, Hangzhou 310030, ChinaCenBRAIN Neurotech Center of Excellence, School of Engineering, Westlake University, Hangzhou 310030, ChinaCenBRAIN Neurotech Center of Excellence, School of Engineering, Westlake University, Hangzhou 310030, ChinaSkulls with high optical scattering and acoustic attenuation are a great challenge for photoacoustic imaging for human beings. To explore and improve photoacoustic generation and propagation, we conducted the photoacoustic simulation and image reconstruction of the multi-layer brain model with an embedded blood vessel under different optical source types. Based on the optical simulation results under different types of optical sources, we explored the characteristics of reconstructed images obtained from acoustic simulations with and without skull conditions. Specifically, we focused on the detection of blood vessels and evaluated the image reconstruction features, morphological characteristics, and intensity of variations in the target vessels using optical and acoustic simulations. The results showed that under the initial PA signals, the types of optical source types corresponding to the strongest and weakest photoacoustic signals at different positions within the target region were consistent, while the optical source types were different in the reconstructed images. This study revealed the characteristics of acoustic signal transmission with and without skull conditions and its impact on image reconstruction. It further provides a theoretical basis for the selection of optical sources.https://www.mdpi.com/2306-5354/12/1/40brain imagingoptical simulationMonte Carlo simulationacoustic simulationk-waveskull |
spellingShingle | Xi Yang Chengpeng Chai Yun-Hsuan Chen Mohamad Sawan Skull Impact on Photoacoustic Imaging of Multi-Layered Brain Tissues with Embedded Blood Vessel Under Different Optical Source Types: Modeling and Simulation Bioengineering brain imaging optical simulation Monte Carlo simulation acoustic simulation k-wave skull |
title | Skull Impact on Photoacoustic Imaging of Multi-Layered Brain Tissues with Embedded Blood Vessel Under Different Optical Source Types: Modeling and Simulation |
title_full | Skull Impact on Photoacoustic Imaging of Multi-Layered Brain Tissues with Embedded Blood Vessel Under Different Optical Source Types: Modeling and Simulation |
title_fullStr | Skull Impact on Photoacoustic Imaging of Multi-Layered Brain Tissues with Embedded Blood Vessel Under Different Optical Source Types: Modeling and Simulation |
title_full_unstemmed | Skull Impact on Photoacoustic Imaging of Multi-Layered Brain Tissues with Embedded Blood Vessel Under Different Optical Source Types: Modeling and Simulation |
title_short | Skull Impact on Photoacoustic Imaging of Multi-Layered Brain Tissues with Embedded Blood Vessel Under Different Optical Source Types: Modeling and Simulation |
title_sort | skull impact on photoacoustic imaging of multi layered brain tissues with embedded blood vessel under different optical source types modeling and simulation |
topic | brain imaging optical simulation Monte Carlo simulation acoustic simulation k-wave skull |
url | https://www.mdpi.com/2306-5354/12/1/40 |
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