Short-Term Outcome of Patients with Cirrhosis and Concurrent Portal Cavernoma Presenting with Acute Variceal Bleeding
Background and Aim. The outcome of cirrhotic patients with main portal vein occlusion and portal cavernoma after the first episode of acute variceal bleeding (AVB) is unknown. We compared short-term outcomes after AVB in cirrhotic patients with and without portal cavernoma. Methods. Between January...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Canadian Journal of Gastroenterology and Hepatology |
| Online Access: | http://dx.doi.org/10.1155/2018/9491856 |
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| author | Xuefeng Luo Wanqin Wang Xiaoli Fan Ying Zhao Xiaoze Wang Jinlin Yang Li Yang |
| author_facet | Xuefeng Luo Wanqin Wang Xiaoli Fan Ying Zhao Xiaoze Wang Jinlin Yang Li Yang |
| author_sort | Xuefeng Luo |
| collection | DOAJ |
| description | Background and Aim. The outcome of cirrhotic patients with main portal vein occlusion and portal cavernoma after the first episode of acute variceal bleeding (AVB) is unknown. We compared short-term outcomes after AVB in cirrhotic patients with and without portal cavernoma. Methods. Between January 2009 and September 2014, 28 patients with cirrhosis and portal cavernoma presenting with the first occurrence of AVB and 56 age-, sex-, and Child-Pugh score-matched cirrhotic patients without portal cavernoma were included. The primary endpoints were 5-day treatment failure and 6-week mortality. Results. The 5-day treatment failure rate was higher in the cavernoma group than in the control group (32.1% versus 12.5%; p=0.031). The 6-week mortality rate did not differ between the cavernoma and control group (25% versus 12.5%, p=0.137). Multivariable Cox proportional hazard regression analyses revealed that 5-day treatment failure (HR = 1.223, 95% CI = 1.082 to 1.384; p=0.001) independently predicted 6-week mortality. Conclusions. Cirrhotic patients with AVB and portal cavernoma have worse short-term prognosis than patients without portal cavernoma. The 5-day treatment failure was an independent risk factor for 6-week mortality in patients with cirrhosis and portal cavernoma. |
| format | Article |
| id | doaj-art-b805a4f5426b49519bee526c1b3124b1 |
| institution | Kabale University |
| issn | 2291-2789 2291-2797 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Gastroenterology and Hepatology |
| spelling | doaj-art-b805a4f5426b49519bee526c1b3124b12025-02-03T07:26:10ZengWileyCanadian Journal of Gastroenterology and Hepatology2291-27892291-27972018-01-01201810.1155/2018/94918569491856Short-Term Outcome of Patients with Cirrhosis and Concurrent Portal Cavernoma Presenting with Acute Variceal BleedingXuefeng Luo0Wanqin Wang1Xiaoli Fan2Ying Zhao3Xiaoze Wang4Jinlin Yang5Li Yang6Department of Gastroenterology and Hepatology, West China Hospital, Sichuan University, Chengdu, ChinaDepartment of Gastroenterology and Hepatology, West China Hospital, Sichuan University, Chengdu, ChinaDepartment of Gastroenterology and Hepatology, West China Hospital, Sichuan University, Chengdu, ChinaDepartment of Gastroenterology and Hepatology, West China Hospital, Sichuan University, Chengdu, ChinaDepartment of Gastroenterology and Hepatology, West China Hospital, Sichuan University, Chengdu, ChinaDepartment of Gastroenterology and Hepatology, West China Hospital, Sichuan University, Chengdu, ChinaDepartment of Gastroenterology and Hepatology, West China Hospital, Sichuan University, Chengdu, ChinaBackground and Aim. The outcome of cirrhotic patients with main portal vein occlusion and portal cavernoma after the first episode of acute variceal bleeding (AVB) is unknown. We compared short-term outcomes after AVB in cirrhotic patients with and without portal cavernoma. Methods. Between January 2009 and September 2014, 28 patients with cirrhosis and portal cavernoma presenting with the first occurrence of AVB and 56 age-, sex-, and Child-Pugh score-matched cirrhotic patients without portal cavernoma were included. The primary endpoints were 5-day treatment failure and 6-week mortality. Results. The 5-day treatment failure rate was higher in the cavernoma group than in the control group (32.1% versus 12.5%; p=0.031). The 6-week mortality rate did not differ between the cavernoma and control group (25% versus 12.5%, p=0.137). Multivariable Cox proportional hazard regression analyses revealed that 5-day treatment failure (HR = 1.223, 95% CI = 1.082 to 1.384; p=0.001) independently predicted 6-week mortality. Conclusions. Cirrhotic patients with AVB and portal cavernoma have worse short-term prognosis than patients without portal cavernoma. The 5-day treatment failure was an independent risk factor for 6-week mortality in patients with cirrhosis and portal cavernoma.http://dx.doi.org/10.1155/2018/9491856 |
| spellingShingle | Xuefeng Luo Wanqin Wang Xiaoli Fan Ying Zhao Xiaoze Wang Jinlin Yang Li Yang Short-Term Outcome of Patients with Cirrhosis and Concurrent Portal Cavernoma Presenting with Acute Variceal Bleeding Canadian Journal of Gastroenterology and Hepatology |
| title | Short-Term Outcome of Patients with Cirrhosis and Concurrent Portal Cavernoma Presenting with Acute Variceal Bleeding |
| title_full | Short-Term Outcome of Patients with Cirrhosis and Concurrent Portal Cavernoma Presenting with Acute Variceal Bleeding |
| title_fullStr | Short-Term Outcome of Patients with Cirrhosis and Concurrent Portal Cavernoma Presenting with Acute Variceal Bleeding |
| title_full_unstemmed | Short-Term Outcome of Patients with Cirrhosis and Concurrent Portal Cavernoma Presenting with Acute Variceal Bleeding |
| title_short | Short-Term Outcome of Patients with Cirrhosis and Concurrent Portal Cavernoma Presenting with Acute Variceal Bleeding |
| title_sort | short term outcome of patients with cirrhosis and concurrent portal cavernoma presenting with acute variceal bleeding |
| url | http://dx.doi.org/10.1155/2018/9491856 |
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