The Partial Duplication of the 5′ Segment of KMT2A Revealed KMT2A-MLLT10 Rearrangement in a Boy with Acute Myeloid Leukemia
The duplication of 5′ segment of KMT2A is a rare molecular event in childhood leukemia, and the influence on prognosis is unknown. Here, we report on a boy who developed acute monocytic leukemia. Fluorescence in situ hybridization revealed the duplication of the 5′ segment with 2 normal alleles at K...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Case Reports in Pediatrics |
| Online Access: | http://dx.doi.org/10.1155/2017/6257494 |
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| author | Hiroko Fukushima Toru Nanmoku Sho Hosaka Yuni Yamaki Nobutaka Kiyokawa Takashi Fukushima Ryo Sumazaki |
| author_facet | Hiroko Fukushima Toru Nanmoku Sho Hosaka Yuni Yamaki Nobutaka Kiyokawa Takashi Fukushima Ryo Sumazaki |
| author_sort | Hiroko Fukushima |
| collection | DOAJ |
| description | The duplication of 5′ segment of KMT2A is a rare molecular event in childhood leukemia, and the influence on prognosis is unknown. Here, we report on a boy who developed acute monocytic leukemia. Fluorescence in situ hybridization revealed the duplication of the 5′ segment with 2 normal alleles at KMT2A which was eventually found to be fused with MLLT10. Chemotherapy promptly induced the first complete remission in the patient at our facility, and the patient remained in first complete remission with negative minimal residual disease at 3.5 years from diagnosis. Our case is similar to two previously reported patients who had partial duplication of the 5′ segment of KMT2A with a KMT2A-MLLT10 rearrangement. Further studies and experience with this cryptic translocation may shed more light on the management of acute myeloid leukemia. |
| format | Article |
| id | doaj-art-b7ffe523edc94f259dd684d70e280e15 |
| institution | Kabale University |
| issn | 2090-6803 2090-6811 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Pediatrics |
| spelling | doaj-art-b7ffe523edc94f259dd684d70e280e152025-02-03T05:48:16ZengWileyCase Reports in Pediatrics2090-68032090-68112017-01-01201710.1155/2017/62574946257494The Partial Duplication of the 5′ Segment of KMT2A Revealed KMT2A-MLLT10 Rearrangement in a Boy with Acute Myeloid LeukemiaHiroko Fukushima0Toru Nanmoku1Sho Hosaka2Yuni Yamaki3Nobutaka Kiyokawa4Takashi Fukushima5Ryo Sumazaki6Department of Child Health, Faculty of Medicine, University of Tsukuba, Ibaraki, JapanDepartment of Clinical Laboratory, University of Tsukuba Hospital, Ibaraki, JapanDepartment of Pediatrics, University of Tsukuba Hospital, Ibaraki, JapanDepartment of Pediatrics, University of Tsukuba Hospital, Ibaraki, JapanDepartment of Pediatric Haematology and Oncology Research, National Research Institute for Child Health and Development, Tokyo, JapanDepartment of Child Health, Faculty of Medicine, University of Tsukuba, Ibaraki, JapanDepartment of Child Health, Faculty of Medicine, University of Tsukuba, Ibaraki, JapanThe duplication of 5′ segment of KMT2A is a rare molecular event in childhood leukemia, and the influence on prognosis is unknown. Here, we report on a boy who developed acute monocytic leukemia. Fluorescence in situ hybridization revealed the duplication of the 5′ segment with 2 normal alleles at KMT2A which was eventually found to be fused with MLLT10. Chemotherapy promptly induced the first complete remission in the patient at our facility, and the patient remained in first complete remission with negative minimal residual disease at 3.5 years from diagnosis. Our case is similar to two previously reported patients who had partial duplication of the 5′ segment of KMT2A with a KMT2A-MLLT10 rearrangement. Further studies and experience with this cryptic translocation may shed more light on the management of acute myeloid leukemia.http://dx.doi.org/10.1155/2017/6257494 |
| spellingShingle | Hiroko Fukushima Toru Nanmoku Sho Hosaka Yuni Yamaki Nobutaka Kiyokawa Takashi Fukushima Ryo Sumazaki The Partial Duplication of the 5′ Segment of KMT2A Revealed KMT2A-MLLT10 Rearrangement in a Boy with Acute Myeloid Leukemia Case Reports in Pediatrics |
| title | The Partial Duplication of the 5′ Segment of KMT2A Revealed KMT2A-MLLT10 Rearrangement in a Boy with Acute Myeloid Leukemia |
| title_full | The Partial Duplication of the 5′ Segment of KMT2A Revealed KMT2A-MLLT10 Rearrangement in a Boy with Acute Myeloid Leukemia |
| title_fullStr | The Partial Duplication of the 5′ Segment of KMT2A Revealed KMT2A-MLLT10 Rearrangement in a Boy with Acute Myeloid Leukemia |
| title_full_unstemmed | The Partial Duplication of the 5′ Segment of KMT2A Revealed KMT2A-MLLT10 Rearrangement in a Boy with Acute Myeloid Leukemia |
| title_short | The Partial Duplication of the 5′ Segment of KMT2A Revealed KMT2A-MLLT10 Rearrangement in a Boy with Acute Myeloid Leukemia |
| title_sort | partial duplication of the 5 segment of kmt2a revealed kmt2a mllt10 rearrangement in a boy with acute myeloid leukemia |
| url | http://dx.doi.org/10.1155/2017/6257494 |
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