Antifungal Constituents from the Roots of Piper dilatatum Rich.
The compounds (+)-(7S,8R)-epoxy-5,6-didehydrokavain (1), flavokavain B (2), β-sitosterol (3), and stigmasterol (4) are reported here as chemical constituents of Piper dilatatum Rich. (Piperaceae). Their structures were determined on the basis of their spectroscopic data (1H and 13C NMR, MS, and IR)...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2013/160165 |
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| author | Ruilan Alves dos Santos Clécio Souza Ramos Maria Cláudia M. Young Thamilles Gonçalves Pinheiro André M. Amorim Massuo J. Kato Ronan Batista |
| author_facet | Ruilan Alves dos Santos Clécio Souza Ramos Maria Cláudia M. Young Thamilles Gonçalves Pinheiro André M. Amorim Massuo J. Kato Ronan Batista |
| author_sort | Ruilan Alves dos Santos |
| collection | DOAJ |
| description | The compounds (+)-(7S,8R)-epoxy-5,6-didehydrokavain (1), flavokavain B (2), β-sitosterol (3), and stigmasterol (4) are reported here as chemical constituents of Piper dilatatum Rich. (Piperaceae). Their structures were determined on the basis of their spectroscopic data (1H and 13C NMR, MS, and IR). The antifungal activities of pyrone 1 (1 μg) and chalcone 2 (100 μg) were determined by means of direct bioautography against Cladosporium cladosporioides and C. sphaerospermum. Results indicate P. dilatatum as a candidate for the development of novel antifungal phytotherapic products as well as point out pyrone 1 as a promising hit compound in the quest for novel antifungal agents. |
| format | Article |
| id | doaj-art-b7e75c6b69cd425e821dae7d7df8105d |
| institution | Kabale University |
| issn | 2090-9063 2090-9071 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Chemistry |
| spelling | doaj-art-b7e75c6b69cd425e821dae7d7df8105d2025-02-03T01:02:08ZengWileyJournal of Chemistry2090-90632090-90712013-01-01201310.1155/2013/160165160165Antifungal Constituents from the Roots of Piper dilatatum Rich.Ruilan Alves dos Santos0Clécio Souza Ramos1Maria Cláudia M. Young2Thamilles Gonçalves Pinheiro3André M. Amorim4Massuo J. Kato5Ronan Batista6Departamento de Estudos Básicos e Instrumentais, Universidade Estadual do Sudoeste da Bahia, BR 415, Km 03, s/n, 45700-000 Itapetinga, BA, BrazilDepartamento de Ciências Moleculares, Universidade Federal Rural de Pernambuco, Rua Dom Manoel de Medeiros, s/n, 52171-030 Recife, PE, BrazilSeção de Fisiologia e Bioquímica de Plantas, Instituto de Botânica, CP 3005, 01061-970 São Paulo, SP, BrazilDepartamento de Estudos Básicos e Instrumentais, Universidade Estadual do Sudoeste da Bahia, BR 415, Km 03, s/n, 45700-000 Itapetinga, BA, BrazilDepartamento de Ciências Biológicas, Universidade Estadual de Santa Cruz, Rodovia Ilhéus-Itabuna, Km 16, 45662-900 Ilhéus, BA, BrazilInstituto de Química, Universidade de São Paulo, CP 26077, 05513-970 São Paulo, SP, BrazilInstituto de Química, Universidade Federal da Bahia, Rua Barão de Geremoabo, s/n, Ondina, 40170-290 Salvador, BA, BrazilThe compounds (+)-(7S,8R)-epoxy-5,6-didehydrokavain (1), flavokavain B (2), β-sitosterol (3), and stigmasterol (4) are reported here as chemical constituents of Piper dilatatum Rich. (Piperaceae). Their structures were determined on the basis of their spectroscopic data (1H and 13C NMR, MS, and IR). The antifungal activities of pyrone 1 (1 μg) and chalcone 2 (100 μg) were determined by means of direct bioautography against Cladosporium cladosporioides and C. sphaerospermum. Results indicate P. dilatatum as a candidate for the development of novel antifungal phytotherapic products as well as point out pyrone 1 as a promising hit compound in the quest for novel antifungal agents.http://dx.doi.org/10.1155/2013/160165 |
| spellingShingle | Ruilan Alves dos Santos Clécio Souza Ramos Maria Cláudia M. Young Thamilles Gonçalves Pinheiro André M. Amorim Massuo J. Kato Ronan Batista Antifungal Constituents from the Roots of Piper dilatatum Rich. Journal of Chemistry |
| title | Antifungal Constituents from the Roots of Piper dilatatum Rich. |
| title_full | Antifungal Constituents from the Roots of Piper dilatatum Rich. |
| title_fullStr | Antifungal Constituents from the Roots of Piper dilatatum Rich. |
| title_full_unstemmed | Antifungal Constituents from the Roots of Piper dilatatum Rich. |
| title_short | Antifungal Constituents from the Roots of Piper dilatatum Rich. |
| title_sort | antifungal constituents from the roots of piper dilatatum rich |
| url | http://dx.doi.org/10.1155/2013/160165 |
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