Study on the relationship between sleep–wake states and prognosis in patients with intracranial arterial stenosis and ischemic stroke
ObjectiveTo evaluate the influence of the sleep–wake state on the prognosis of patients with ischemic stroke.MethodsConsecutive patients with intracranial ischemic stroke due to arterial stenosis were included (198 cases). The control group consisted of contemporaneous patients without cerebrovascul...
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Frontiers Media S.A.
2025-06-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2025.1531241/full |
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| author | Xiaodong Yuan Xiaodong Yuan Jing Xue Jing Xue Yongshan Fu Yongshan Fu Ya Ou Ying Zhao Ying Zhao Cuiping Yan Cuiping Yan Pingshu Zhang Pingshu Zhang |
| author_facet | Xiaodong Yuan Xiaodong Yuan Jing Xue Jing Xue Yongshan Fu Yongshan Fu Ya Ou Ying Zhao Ying Zhao Cuiping Yan Cuiping Yan Pingshu Zhang Pingshu Zhang |
| author_sort | Xiaodong Yuan |
| collection | DOAJ |
| description | ObjectiveTo evaluate the influence of the sleep–wake state on the prognosis of patients with ischemic stroke.MethodsConsecutive patients with intracranial ischemic stroke due to arterial stenosis were included (198 cases). The control group consisted of contemporaneous patients without cerebrovascular stenosis or any diagnosed cerebrovascular disease (77 cases). Collect the following variables of the patients, including the total recording time during the day and night, total sleep time, sleep latency, rapid eye movement (REM) sleep latency, wake time after falling asleep, light sleep stage (N1, N2 stage), deep sleep stage (N3 stage), and non-rapid eye movement (non-rapid eye movement) (NREM) sleep stage, rapid eye movement (REM) sleep stage, and stroke topography (anterior circulation and posterior circulation ischemic stroke). The primary outcome was the functional status at discharge, evaluated using the modified Rankin Scale (mRS): good prognosis (mRS ≤ 2) and poor prognosis (mRS > 2).ResultsIn the regression analysis of prognostic influencing factors in patients with ACIS, it was concluded that an increase in daytime deep sleep time was associated with an increased possibility of adverse outcomes in patients with ACIS (OR = 1.026; 95% CI, 1.003–1.048, p = 0.024). In the regression analysis of prognostic influencing factors in patients with PCIS, it was concluded that during PCIS, the duration of deep sleep was longer (OR = 1.038; 95% CI, 1.001–1.077, p = 0.046) and the duration of nocturnal NREM staging was longer (OR = 1.010; patients with 95% CI, 1.000–1.020, p = 0.042) had a higher possibility of adverse outcomes.ConclusionThe sleep–wake state of patients with intracranial artery stenoischemic stroke changes. The main characteristics are increased diurnal sleep, increased incidence of daytime sleep, and disordered sleep–wake phases. In patients with ACIS, the diurnal sleep–wake biological rhythm mainly characterized by poor daytime stability is unbalanced. The longer the duration of daytime deep sleep and nighttime NREM sleep, the higher the possibility of adverse outcomes in patients with intracranial artery stenotic ischemic stroke. |
| format | Article |
| id | doaj-art-b7e03e6e33704f64b5e280cbc1eaea85 |
| institution | Kabale University |
| issn | 1664-2295 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Neurology |
| spelling | doaj-art-b7e03e6e33704f64b5e280cbc1eaea852025-08-20T03:32:19ZengFrontiers Media S.A.Frontiers in Neurology1664-22952025-06-011610.3389/fneur.2025.15312411531241Study on the relationship between sleep–wake states and prognosis in patients with intracranial arterial stenosis and ischemic strokeXiaodong Yuan0Xiaodong Yuan1Jing Xue2Jing Xue3Yongshan Fu4Yongshan Fu5Ya Ou6Ying Zhao7Ying Zhao8Cuiping Yan9Cuiping Yan10Pingshu Zhang11Pingshu Zhang12Department of Neurology, Kailuan General Hospital, North China University of Science and Technology, Tangshan, ChinaKey Laboratory of Neurobiological Function, Tangshan, ChinaDepartment of Neurology, Kailuan General Hospital, North China University of Science and Technology, Tangshan, ChinaKey Laboratory of Neurobiological Function, Tangshan, ChinaDepartment of Neurology, Kailuan General Hospital, North China University of Science and Technology, Tangshan, ChinaKey Laboratory of Neurobiological Function, Tangshan, ChinaDepartment of Neurology, Kailuan General Hospital, North China University of Science and Technology, Tangshan, ChinaDepartment of Neurology, Kailuan General Hospital, North China University of Science and Technology, Tangshan, ChinaKey Laboratory of Neurobiological Function, Tangshan, ChinaDepartment of Neurology, Kailuan General Hospital, North China University of Science and Technology, Tangshan, ChinaKey Laboratory of Neurobiological Function, Tangshan, ChinaDepartment of Neurology, Kailuan General Hospital, North China University of Science and Technology, Tangshan, ChinaKey Laboratory of Neurobiological Function, Tangshan, ChinaObjectiveTo evaluate the influence of the sleep–wake state on the prognosis of patients with ischemic stroke.MethodsConsecutive patients with intracranial ischemic stroke due to arterial stenosis were included (198 cases). The control group consisted of contemporaneous patients without cerebrovascular stenosis or any diagnosed cerebrovascular disease (77 cases). Collect the following variables of the patients, including the total recording time during the day and night, total sleep time, sleep latency, rapid eye movement (REM) sleep latency, wake time after falling asleep, light sleep stage (N1, N2 stage), deep sleep stage (N3 stage), and non-rapid eye movement (non-rapid eye movement) (NREM) sleep stage, rapid eye movement (REM) sleep stage, and stroke topography (anterior circulation and posterior circulation ischemic stroke). The primary outcome was the functional status at discharge, evaluated using the modified Rankin Scale (mRS): good prognosis (mRS ≤ 2) and poor prognosis (mRS > 2).ResultsIn the regression analysis of prognostic influencing factors in patients with ACIS, it was concluded that an increase in daytime deep sleep time was associated with an increased possibility of adverse outcomes in patients with ACIS (OR = 1.026; 95% CI, 1.003–1.048, p = 0.024). In the regression analysis of prognostic influencing factors in patients with PCIS, it was concluded that during PCIS, the duration of deep sleep was longer (OR = 1.038; 95% CI, 1.001–1.077, p = 0.046) and the duration of nocturnal NREM staging was longer (OR = 1.010; patients with 95% CI, 1.000–1.020, p = 0.042) had a higher possibility of adverse outcomes.ConclusionThe sleep–wake state of patients with intracranial artery stenoischemic stroke changes. The main characteristics are increased diurnal sleep, increased incidence of daytime sleep, and disordered sleep–wake phases. In patients with ACIS, the diurnal sleep–wake biological rhythm mainly characterized by poor daytime stability is unbalanced. The longer the duration of daytime deep sleep and nighttime NREM sleep, the higher the possibility of adverse outcomes in patients with intracranial artery stenotic ischemic stroke.https://www.frontiersin.org/articles/10.3389/fneur.2025.1531241/fullintracranial arterial stenosisischemic strokesleep–wake stateprognosisprognostic factors analysis |
| spellingShingle | Xiaodong Yuan Xiaodong Yuan Jing Xue Jing Xue Yongshan Fu Yongshan Fu Ya Ou Ying Zhao Ying Zhao Cuiping Yan Cuiping Yan Pingshu Zhang Pingshu Zhang Study on the relationship between sleep–wake states and prognosis in patients with intracranial arterial stenosis and ischemic stroke Frontiers in Neurology intracranial arterial stenosis ischemic stroke sleep–wake state prognosis prognostic factors analysis |
| title | Study on the relationship between sleep–wake states and prognosis in patients with intracranial arterial stenosis and ischemic stroke |
| title_full | Study on the relationship between sleep–wake states and prognosis in patients with intracranial arterial stenosis and ischemic stroke |
| title_fullStr | Study on the relationship between sleep–wake states and prognosis in patients with intracranial arterial stenosis and ischemic stroke |
| title_full_unstemmed | Study on the relationship between sleep–wake states and prognosis in patients with intracranial arterial stenosis and ischemic stroke |
| title_short | Study on the relationship between sleep–wake states and prognosis in patients with intracranial arterial stenosis and ischemic stroke |
| title_sort | study on the relationship between sleep wake states and prognosis in patients with intracranial arterial stenosis and ischemic stroke |
| topic | intracranial arterial stenosis ischemic stroke sleep–wake state prognosis prognostic factors analysis |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2025.1531241/full |
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