The Role of Microglia and Matrix Metalloproteinases Involvement in Neuroinflammation and Gliomas

Matrix metalloproteinases (MMPs) are involved in the pathogenesis of neuroinflammatory diseases (such as multiple sclerosis) as well as in the expansion of malignant gliomas because they facilitate penetration of anatomical barriers (such as the glia limitans) and migration within the neuropil. This...

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Main Authors: Helen Könnecke, Ingo Bechmann
Format: Article
Language:English
Published: Wiley 2013-01-01
Series:Clinical and Developmental Immunology
Online Access:http://dx.doi.org/10.1155/2013/914104
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author Helen Könnecke
Ingo Bechmann
author_facet Helen Könnecke
Ingo Bechmann
author_sort Helen Könnecke
collection DOAJ
description Matrix metalloproteinases (MMPs) are involved in the pathogenesis of neuroinflammatory diseases (such as multiple sclerosis) as well as in the expansion of malignant gliomas because they facilitate penetration of anatomical barriers (such as the glia limitans) and migration within the neuropil. This review elucidates pathomechanisms and summarizes the current knowledge of the involvement of MMPs in neuroinflammation and glioma, invasion highlighting microglia as major sources of MMPs. The induction of expression, suppression, and multiple pathways of function of MMPs in these scenarios will also be discussed. Understanding the induction and action of MMPs might provide valuable information and reveal attractive targets for future therapeutic strategies.
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spelling doaj-art-b7d6e962015e4ce9853645ebf04cc03c2025-02-03T01:31:05ZengWileyClinical and Developmental Immunology1740-25221740-25302013-01-01201310.1155/2013/914104914104The Role of Microglia and Matrix Metalloproteinases Involvement in Neuroinflammation and GliomasHelen Könnecke0Ingo Bechmann1Clinic of Neurology, University of Zurich, Frauenklinikstrasse 26, 8091 Zurich, SwitzerlandInstitute of Anatomy, University of Leipzig, Liebigstrasse 13, 04103 Leipzig, GermanyMatrix metalloproteinases (MMPs) are involved in the pathogenesis of neuroinflammatory diseases (such as multiple sclerosis) as well as in the expansion of malignant gliomas because they facilitate penetration of anatomical barriers (such as the glia limitans) and migration within the neuropil. This review elucidates pathomechanisms and summarizes the current knowledge of the involvement of MMPs in neuroinflammation and glioma, invasion highlighting microglia as major sources of MMPs. The induction of expression, suppression, and multiple pathways of function of MMPs in these scenarios will also be discussed. Understanding the induction and action of MMPs might provide valuable information and reveal attractive targets for future therapeutic strategies.http://dx.doi.org/10.1155/2013/914104
spellingShingle Helen Könnecke
Ingo Bechmann
The Role of Microglia and Matrix Metalloproteinases Involvement in Neuroinflammation and Gliomas
Clinical and Developmental Immunology
title The Role of Microglia and Matrix Metalloproteinases Involvement in Neuroinflammation and Gliomas
title_full The Role of Microglia and Matrix Metalloproteinases Involvement in Neuroinflammation and Gliomas
title_fullStr The Role of Microglia and Matrix Metalloproteinases Involvement in Neuroinflammation and Gliomas
title_full_unstemmed The Role of Microglia and Matrix Metalloproteinases Involvement in Neuroinflammation and Gliomas
title_short The Role of Microglia and Matrix Metalloproteinases Involvement in Neuroinflammation and Gliomas
title_sort role of microglia and matrix metalloproteinases involvement in neuroinflammation and gliomas
url http://dx.doi.org/10.1155/2013/914104
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