The Role of Microglia and Matrix Metalloproteinases Involvement in Neuroinflammation and Gliomas
Matrix metalloproteinases (MMPs) are involved in the pathogenesis of neuroinflammatory diseases (such as multiple sclerosis) as well as in the expansion of malignant gliomas because they facilitate penetration of anatomical barriers (such as the glia limitans) and migration within the neuropil. This...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1155/2013/914104 |
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| _version_ | 1832559027473612800 |
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| author | Helen Könnecke Ingo Bechmann |
| author_facet | Helen Könnecke Ingo Bechmann |
| author_sort | Helen Könnecke |
| collection | DOAJ |
| description | Matrix metalloproteinases (MMPs) are involved in the pathogenesis of neuroinflammatory diseases (such as multiple sclerosis) as well as in the expansion of malignant gliomas because they facilitate penetration of anatomical barriers (such as the glia limitans) and migration within the neuropil. This review elucidates pathomechanisms and summarizes the current knowledge of the involvement of MMPs in neuroinflammation and glioma, invasion highlighting microglia as major sources of MMPs. The induction of expression, suppression, and multiple pathways of function of MMPs in these scenarios will also be discussed. Understanding the induction and action of MMPs might provide valuable information and reveal attractive targets for future therapeutic strategies. |
| format | Article |
| id | doaj-art-b7d6e962015e4ce9853645ebf04cc03c |
| institution | Kabale University |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Developmental Immunology |
| spelling | doaj-art-b7d6e962015e4ce9853645ebf04cc03c2025-02-03T01:31:05ZengWileyClinical and Developmental Immunology1740-25221740-25302013-01-01201310.1155/2013/914104914104The Role of Microglia and Matrix Metalloproteinases Involvement in Neuroinflammation and GliomasHelen Könnecke0Ingo Bechmann1Clinic of Neurology, University of Zurich, Frauenklinikstrasse 26, 8091 Zurich, SwitzerlandInstitute of Anatomy, University of Leipzig, Liebigstrasse 13, 04103 Leipzig, GermanyMatrix metalloproteinases (MMPs) are involved in the pathogenesis of neuroinflammatory diseases (such as multiple sclerosis) as well as in the expansion of malignant gliomas because they facilitate penetration of anatomical barriers (such as the glia limitans) and migration within the neuropil. This review elucidates pathomechanisms and summarizes the current knowledge of the involvement of MMPs in neuroinflammation and glioma, invasion highlighting microglia as major sources of MMPs. The induction of expression, suppression, and multiple pathways of function of MMPs in these scenarios will also be discussed. Understanding the induction and action of MMPs might provide valuable information and reveal attractive targets for future therapeutic strategies.http://dx.doi.org/10.1155/2013/914104 |
| spellingShingle | Helen Könnecke Ingo Bechmann The Role of Microglia and Matrix Metalloproteinases Involvement in Neuroinflammation and Gliomas Clinical and Developmental Immunology |
| title | The Role of Microglia and Matrix Metalloproteinases Involvement in Neuroinflammation and Gliomas |
| title_full | The Role of Microglia and Matrix Metalloproteinases Involvement in Neuroinflammation and Gliomas |
| title_fullStr | The Role of Microglia and Matrix Metalloproteinases Involvement in Neuroinflammation and Gliomas |
| title_full_unstemmed | The Role of Microglia and Matrix Metalloproteinases Involvement in Neuroinflammation and Gliomas |
| title_short | The Role of Microglia and Matrix Metalloproteinases Involvement in Neuroinflammation and Gliomas |
| title_sort | role of microglia and matrix metalloproteinases involvement in neuroinflammation and gliomas |
| url | http://dx.doi.org/10.1155/2013/914104 |
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