Determination of the structure of a new potentially active pharmaceutical substance

Determination of the structure of a new potentially active pharmaceutical substance

Introduction. The development of methods for analyzing new potentially active pharmaceutical substances is an important part of substance standardization. An integrated approach to confirming the structure of a substance is especially important when the substance may exist in different tautomeric fo...

Full description

Saved in:

Bibliographic Details
Main Authors:	T. V. Sotnikova, O. Yu. Strelova, E. P. Sanaeva, D. A. Kolesnik, I. P. Yakovlev
Format:	Article
Language:	Russian
Published:	LLC Center of Pharmaceutical Analytics (LLC «CPHA») 2025-03-01
Series:	Разработка и регистрация лекарственных средств
Subjects:	5-butyl-6-hydroxy-2,3-diphenylpyrimidin-4(3h)-one confirmation of the structure of the substance tautomers
Online Access:	https://www.pharmjournal.ru/jour/article/view/1996
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Modification of the terms of authorisation regarding the maximum inclusion level of a feed additive consisting of 4‐hydroxy‐2,5‐dimethylfuran‐3(2H)‐one for cats and dogs (V. MANE FILS)
by: EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP), et al.
Published: (2024-04-01)

Structural characterization of hydrogen bonding for antipyrine derivatives: Single-crystal X-ray diffraction and theoretical studies
by: N. S. Rukk, et al.
Published: (2021-05-01)

Ionic liquid 1-butyl-3-methylimidazolium bromide: A green reaction media for the efficient synthesis of 3-methyl-1,4-diphenyl-1,4,5,7-tetrahydro-pyrazolo[3,4-d]pyrimidine-6-ones/thiones using phthalimide-N-sulfonic acid as catalyst
by: S.P.N. Sudhan, et al.
Published: (2018-03-01)

Nematicidal action of Clonostachys rosea against Meloidogyne incognita: in-vitro and in-silico analyses
by: Gowrisri Nagaraj, et al.
Published: (2024-12-01)

Preparation, Identification and study Antibacterial Activity of Some new 2,3- Dihydroquinazolin-4 (1H)-one Derivatives
by: Fawzi Hameed Jumaa
Published: (2023-01-01)

Spectrophotometric method for the determination of Captopril in pharmaceutical formulations
by: Baghdad Science Journal
Published: (2013-09-01)

Determination of Impurities in New Promising Antioxidants Bis-[3-(3,5-di-tert-butyl-4-hydroxyphenyl)propyl]sulfide and Dodecyl(3,5-dimethyl-4-hydroxybenzyl)sulfide
by: T. G. Shinko, et al.
Published: (2022-02-01)

Study of the Interaction of Benzene-1,4-dicarboxamide with Methylmalonyl Dichloride
by: Anastasia Andreevna Varvarkina, et al.
Published: (2024-11-01)

Citric Acid-Catalyzed Three-Component Synthesis of (<i>E</i>)-3-Aryl-2-styryl-2,3-dihydroquinazoline-4(1<i>H</i>)-ones and Their Mild Oxidation with I<sub>2</sub>/DMSO System into (<i>E</i>)-3-Aryl-2-styrylquinazolin-4(3<i>H</i>)-ones
by: Vladimir V. Kouznetsov, et al.
Published: (2025-03-01)

Waste Tire Oil Fueled CI Engine Combustion Argumentation for Emission Reduction by Butylated Hydroxy Anisole (BHA) Antioxidant
by: R. Saravanan, et al.
Published: (2025-03-01)

Research progress on the synthesis of 4-hydroxy-2,5-dimethyl-3(2H)-furanone by microorganisms
by: SONG Jinpeng, ZHONG Xiufang, LI Xuesi, CAO Zhenhua, PENG Xinhui, FAN Guangsen
Published: (2024-04-01)

Standardization of the Pharmaceutical Substance of Lithium Salt Gamma-lactone of 2,3-dehydro-l-gulonic Acid as a Radio-sensitizing Agent
by: M. S. Tretyakova, et al.
Published: (2023-09-01)

Accelerated synthesis of 3-dihydroquinazolin-4(1H)-one derivatives using nano-SiO2-SO3H as an efficient acidic catalyst
by: Habyl Naeemi, et al.
Published: (2025-05-01)

Use of High Performance Liquid Chromatography in the Analysis of a New Substance VMA-10-18
by: E. S. Mischenko, et al.
Published: (2021-08-01)

Design, synthesis, molecular dynamics studies and biological evaluations of 4-hydroxy-5-pyrrolinone-3-carbohydrazides as HIV-1 integrase inhibitors
by: Nafiseh Karimi, et al.
Published: (2024-12-01)

Electrochemical and theoretical evaluations of 3-(4-chlorophenyl)-7-methyl-5H-[1, 2, 4] triazolo [3,4-b][1,3,4]thiadiazin-6(7H)-one as corrosion inhibitor for copper in nitric acid environment
by: Abd El-Aziz S. Fouda, et al.
Published: (2024-06-01)

Development of UV-spectrophotometry Method of the Quantitative Determination of a New Substance Quinazoline-4(3h)-on Derivate
by: E. S. Mishchenko, et al.
Published: (2020-02-01)

DEVELOPMENT AND VALIDATION OF BIOANALYTICAL METHOD FOR QUANTIFICATION OF PINOLINE AND ITS METABOLITE 6-OH-1,2,3,4-TETRAHYDROCARBOLINE FOR THE PURPOSE OF CYPD26 ACTIVITY DETERMINATION
by: R. K. Abdrashitov, et al.
Published: (2019-01-01)

Antioxidant Activity of Silver-containing Bionanocompositions Based on Humic Substances in Cell Culture
by: E. E. Buyko, et al.
Published: (2021-11-01)

Discovery of 4,5,6,7-Tetrahydrothieno [3,2-b] Pyridine as Novel Fungicide Lead Scaffold
by: Ke Chen, et al.
Published: (2025-07-01)

Synthesis of New O- and S-Containing Polyheteroatomic Systems Based on 3-Substituted Pyran-2-Ones with Lawesson’s Reagent
by: Dinara Ch. Kurenkova, et al.
Published: (2024-12-01)

Exploring the Volatility, Phase Transitions, and Solubility Properties of Five Halogenated Benzaldehydes
by: Ana R. R. P. Almeida, et al.
Published: (2025-03-01)

1-(Dicyanomethylene)-3-hydroxy-1<i>H</i>-indene-2-carboxylic Acid
by: Sofia D. Usova, et al.
Published: (2024-08-01)

Determination of copper Ions (II) in Aqueous Solutions Using Organic Reagent 3-Hydroxy-4-[(2-hydroxy benzylidene) amino] naphthalene Sulphonic Acid-1 (HHBAN) by Spectrophotometric method
by: Mohammad Maarouf, et al.
Published: (2025-07-01)

4-(8-Propyl-2,4-dithioxo-1,3-diazaspiro[4.5]decan-3-yl)spiro[1,5-dihydro-1,5-benzodiazepine-2,3′-indoline]-2′-one)
by: Dimitar Stoitsov, et al.
Published: (2025-05-01)

Safety evaluation of the food enzyme rennet containing chymosin and pepsin A from the abomasum of calves and cows
by: EFSA Panel on Food Contact Materials, Enzymes and Processing Aids (CEP), et al.
Published: (2023-06-01)

Fluorescence Detection of 4-Hydroxy-2,5-dimethyl-3(2H)-furanone Based on Fluorescence Resonance Energy Transfer and Competitive Host–Guest Recognition
by: Xiaowan Zhang, et al.
Published: (2025-03-01)

Separation and characterization of the antioxidant active component from Maillard reaction products in xylose-lysine system
by: Luyan Zhang, et al.
Published: (2024-12-01)

Preparation and Identification of some new Pyrazolopyrin derivatives and their Polymerizations study
by: Baghdad Science Journal
Published: (2014-06-01)

[EMIM]AlCl4-ionic liquid catalyzed mechanochemically assisted green approach towards the synthesis of quinoxaline, 6H-indolo[2,3-b]quinoxaline and benzimidazole derivatives
by: Shafaque M. Shaikh, et al.
Published: (2024-12-01)

Effects of 4-hydroxy-2,5-dimethyl-3(2H)-furanone supplementation on growth performance, serum antioxidant capacity, rumen fermentation characteristics, rumen bacterial quorum sensing, and microbial community in Hu sheep
by: Chuanpei Fu, et al.
Published: (2025-07-01)

Directed synthesis and search of pharmaceutical substances with hypoglycemic activity in the series of 4-aryl-2-hydroxy-4-oxo-2-butenoic acids
by: N. A. Pulina, et al.
Published: (2011-10-01)

Synthesis of 5H-Chromeno[4,3-b]pyridin-5-one derivatives as a backbone of natural product polyneomarline C scaffolds in presence of Et3N and NH4OAc in EtOH
by: Shrishnu Kumar Kundu, et al.
Published: (2022-06-01)

Exploring the Interaction of 3-Hydroxy-4-pyridinone Chelators with Liposome Membrane Models: Insights from DSC and EPR Analysis
by: Luísa M. P. F. Amaral, et al.
Published: (2024-12-01)

Walnut Consumption Reduces Perceived Stress and Improves Mood States in a Sample of Young Adults: A Randomized Cross-Over Trial
by: María Fernanda Zerón-Rugerio, et al.
Published: (2024-02-01)

Introduction to the novel ionic liquid-based catalytic system for the multicomponent preparation of benzo[f]pyrano[3,2-c]chromene and pyrano[3,2-c]chromene derivatives under ultrasonic irradiation condition
by: Nariman Maleki, et al.
Published: (2025-05-01)

Synthesis of new hybrid molecules based on 7-hydroxy-2,2,4-trimethylhydroquinoline derivatives
by: Gribanova, Yana Александровна, et al.
Published: (2025-03-01)

One-pot three-component synthesis of azaspirononatriene derivatives
by: Ali Oudi, et al.
Published: (2025-04-01)

STUDY OF THE EFFECT OF STRUCTURE ON OCTANOL-WATER DISTRIBUTION OF 6-HYDROXYPYRIMIDINE-4-(<i>3H</i>)-ONES DERIVATIVES
by: A. E. Potapova, et al.
Published: (2019-01-01)

SYNTHESIS AND PHYSICAL-CHEMICAL PROPERTIESOF 3-ARIL-2-((3-(3-FLUORPHENYL)-1,2,4-TRIAZOLE-5-YL)THIO)PROP-2-EN-1-OLES
by: O. A. Bigdan, et al.
Published: (2015-04-01)