Tuning Mechanical Properties of Polymeric Hydrogels Using Orthogonally Functionalized Crosslinkers
A unique orthogonal crosslinker-induced hydrogel, whose mechanical strength can be tunable by the crosslinker topology upon thermal treatment, is described herein. The crosslinker containing cationic moieties and crosslinkable styrenyl groups was employed for the preparation of orthogonally crosslin...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2022-01-01
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| Series: | Advances in Polymer Technology |
| Online Access: | http://dx.doi.org/10.1155/2022/2150591 |
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| _version_ | 1832551073358807040 |
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| author | Bin Liu Zhaoyan Hou Yi Bao Lei Hua Xiao Wang Yuanyuan Li Lanying Zhou Zhuo Lv |
| author_facet | Bin Liu Zhaoyan Hou Yi Bao Lei Hua Xiao Wang Yuanyuan Li Lanying Zhou Zhuo Lv |
| author_sort | Bin Liu |
| collection | DOAJ |
| description | A unique orthogonal crosslinker-induced hydrogel, whose mechanical strength can be tunable by the crosslinker topology upon thermal treatment, is described herein. The crosslinker containing cationic moieties and crosslinkable styrenyl groups was employed for the preparation of orthogonally crosslinked hydrogels having ionic and covalent characteristics. The manipulation of the orthogonal crosslinkers topology and the ionic bond strength between cationic and anionic moieties facilitated the control of the mechanical properties. Short-term temporal modulation of hydrogel moduli, a key factor of the substrates for cell development, was demonstrated and could provide dynamic microenvironment for biological process. In addition, on-demand control of the elastic properties of the hydrogels by application of a thermal stimulus provides new avenues to regulate cell growth. Furthermore, the orthogonality of the crosslinkers allowed molecular functionalization of a wide range of molecules of interest to the hydrogels by thiol-ene Michael addition (nucleophilic addition of sulfhydryl and carbon-carbon double bonds) in a friendly manner as demonstrated in our work. |
| format | Article |
| id | doaj-art-b7c50477130142c4916e7424be63ebe7 |
| institution | Kabale University |
| issn | 1098-2329 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advances in Polymer Technology |
| spelling | doaj-art-b7c50477130142c4916e7424be63ebe72025-02-03T06:05:03ZengWileyAdvances in Polymer Technology1098-23292022-01-01202210.1155/2022/2150591Tuning Mechanical Properties of Polymeric Hydrogels Using Orthogonally Functionalized CrosslinkersBin Liu0Zhaoyan Hou1Yi Bao2Lei Hua3Xiao Wang4Yuanyuan Li5Lanying Zhou6Zhuo Lv7Jilin Province Product Quality Supervision and Inspection InstituteChangchun Center for Disease Control and PreventionJilin Province Product Quality Supervision and Inspection InstituteJilin Province Product Quality Supervision and Inspection InstituteJilin Province Product Quality Supervision and Inspection InstituteJilin Province Product Quality Supervision and Inspection InstituteJilin Province Product Quality Supervision and Inspection InstituteJilin Province Product Quality Supervision and Inspection InstituteA unique orthogonal crosslinker-induced hydrogel, whose mechanical strength can be tunable by the crosslinker topology upon thermal treatment, is described herein. The crosslinker containing cationic moieties and crosslinkable styrenyl groups was employed for the preparation of orthogonally crosslinked hydrogels having ionic and covalent characteristics. The manipulation of the orthogonal crosslinkers topology and the ionic bond strength between cationic and anionic moieties facilitated the control of the mechanical properties. Short-term temporal modulation of hydrogel moduli, a key factor of the substrates for cell development, was demonstrated and could provide dynamic microenvironment for biological process. In addition, on-demand control of the elastic properties of the hydrogels by application of a thermal stimulus provides new avenues to regulate cell growth. Furthermore, the orthogonality of the crosslinkers allowed molecular functionalization of a wide range of molecules of interest to the hydrogels by thiol-ene Michael addition (nucleophilic addition of sulfhydryl and carbon-carbon double bonds) in a friendly manner as demonstrated in our work.http://dx.doi.org/10.1155/2022/2150591 |
| spellingShingle | Bin Liu Zhaoyan Hou Yi Bao Lei Hua Xiao Wang Yuanyuan Li Lanying Zhou Zhuo Lv Tuning Mechanical Properties of Polymeric Hydrogels Using Orthogonally Functionalized Crosslinkers Advances in Polymer Technology |
| title | Tuning Mechanical Properties of Polymeric Hydrogels Using Orthogonally Functionalized Crosslinkers |
| title_full | Tuning Mechanical Properties of Polymeric Hydrogels Using Orthogonally Functionalized Crosslinkers |
| title_fullStr | Tuning Mechanical Properties of Polymeric Hydrogels Using Orthogonally Functionalized Crosslinkers |
| title_full_unstemmed | Tuning Mechanical Properties of Polymeric Hydrogels Using Orthogonally Functionalized Crosslinkers |
| title_short | Tuning Mechanical Properties of Polymeric Hydrogels Using Orthogonally Functionalized Crosslinkers |
| title_sort | tuning mechanical properties of polymeric hydrogels using orthogonally functionalized crosslinkers |
| url | http://dx.doi.org/10.1155/2022/2150591 |
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