Roles of the Chemokine System in Development of Obesity, Insulin Resistance, and Cardiovascular Disease
The escalating epidemic of obesity has increased the incidence of obesity-induced complications to historically high levels. Adipose tissue is a dynamic energy depot, which stores energy and mobilizes it during nutrient deficiency. Excess nutrient intake resulting in adipose tissue expansion trigger...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2014/181450 |
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| _version_ | 1832551073143848960 |
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| author | Longbiao Yao Oana Herlea-Pana Janet Heuser-Baker Yitong Chen Jana Barlic-Dicen |
| author_facet | Longbiao Yao Oana Herlea-Pana Janet Heuser-Baker Yitong Chen Jana Barlic-Dicen |
| author_sort | Longbiao Yao |
| collection | DOAJ |
| description | The escalating epidemic of obesity has increased the incidence of obesity-induced complications to historically high levels. Adipose tissue is a dynamic energy depot, which stores energy and mobilizes it during nutrient deficiency. Excess nutrient intake resulting in adipose tissue expansion triggers lipid release and aberrant adipokine, cytokine and chemokine production, and signaling that ultimately lead to adipose tissue inflammation, a hallmark of obesity. This low-grade chronic inflammation is thought to link obesity to insulin resistance and the associated comorbidities of metabolic syndrome such as dyslipidemia and hypertension, which increase risk of type 2 diabetes and cardiovascular disease. In this review, we focus on and discuss members of the chemokine system for which there is clear evidence of participation in the development of obesity and obesity-induced pathologies. |
| format | Article |
| id | doaj-art-b7c305f7d0bd42b092f912d11a5ca051 |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-b7c305f7d0bd42b092f912d11a5ca0512025-02-03T06:05:09ZengWileyJournal of Immunology Research2314-88612314-71562014-01-01201410.1155/2014/181450181450Roles of the Chemokine System in Development of Obesity, Insulin Resistance, and Cardiovascular DiseaseLongbiao Yao0Oana Herlea-Pana1Janet Heuser-Baker2Yitong Chen3Jana Barlic-Dicen4Cardiovascular Biology Program, Oklahoma Medical Research Foundation, 825 NE 13th Street, Oklahoma City, OK 73104, USACardiovascular Biology Program, Oklahoma Medical Research Foundation, 825 NE 13th Street, Oklahoma City, OK 73104, USACardiovascular Biology Program, Oklahoma Medical Research Foundation, 825 NE 13th Street, Oklahoma City, OK 73104, USACardiovascular Biology Program, Oklahoma Medical Research Foundation, 825 NE 13th Street, Oklahoma City, OK 73104, USACardiovascular Biology Program, Oklahoma Medical Research Foundation, 825 NE 13th Street, Oklahoma City, OK 73104, USAThe escalating epidemic of obesity has increased the incidence of obesity-induced complications to historically high levels. Adipose tissue is a dynamic energy depot, which stores energy and mobilizes it during nutrient deficiency. Excess nutrient intake resulting in adipose tissue expansion triggers lipid release and aberrant adipokine, cytokine and chemokine production, and signaling that ultimately lead to adipose tissue inflammation, a hallmark of obesity. This low-grade chronic inflammation is thought to link obesity to insulin resistance and the associated comorbidities of metabolic syndrome such as dyslipidemia and hypertension, which increase risk of type 2 diabetes and cardiovascular disease. In this review, we focus on and discuss members of the chemokine system for which there is clear evidence of participation in the development of obesity and obesity-induced pathologies.http://dx.doi.org/10.1155/2014/181450 |
| spellingShingle | Longbiao Yao Oana Herlea-Pana Janet Heuser-Baker Yitong Chen Jana Barlic-Dicen Roles of the Chemokine System in Development of Obesity, Insulin Resistance, and Cardiovascular Disease Journal of Immunology Research |
| title | Roles of the Chemokine System in Development of Obesity, Insulin Resistance, and Cardiovascular Disease |
| title_full | Roles of the Chemokine System in Development of Obesity, Insulin Resistance, and Cardiovascular Disease |
| title_fullStr | Roles of the Chemokine System in Development of Obesity, Insulin Resistance, and Cardiovascular Disease |
| title_full_unstemmed | Roles of the Chemokine System in Development of Obesity, Insulin Resistance, and Cardiovascular Disease |
| title_short | Roles of the Chemokine System in Development of Obesity, Insulin Resistance, and Cardiovascular Disease |
| title_sort | roles of the chemokine system in development of obesity insulin resistance and cardiovascular disease |
| url | http://dx.doi.org/10.1155/2014/181450 |
| work_keys_str_mv | AT longbiaoyao rolesofthechemokinesystemindevelopmentofobesityinsulinresistanceandcardiovasculardisease AT oanaherleapana rolesofthechemokinesystemindevelopmentofobesityinsulinresistanceandcardiovasculardisease AT janetheuserbaker rolesofthechemokinesystemindevelopmentofobesityinsulinresistanceandcardiovasculardisease AT yitongchen rolesofthechemokinesystemindevelopmentofobesityinsulinresistanceandcardiovasculardisease AT janabarlicdicen rolesofthechemokinesystemindevelopmentofobesityinsulinresistanceandcardiovasculardisease |