Advances in Murine Models of Diabetic Nephropathy
Diabetic nephropathy (DN) is one of the microvascular complications of both type 1 and type 2 diabetes, which is also associated with a poor life expectancy of diabetic patients. However, the pathogenesis of DN is still unclear. Thus, it is of great use to establish appropriate animal models of DN f...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2013/797548 |
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| author | Li-li Kong Hao Wu Wen-peng Cui Wen-hua Zhou Ping Luo Jing Sun Hang Yuan Li-ning Miao |
| author_facet | Li-li Kong Hao Wu Wen-peng Cui Wen-hua Zhou Ping Luo Jing Sun Hang Yuan Li-ning Miao |
| author_sort | Li-li Kong |
| collection | DOAJ |
| description | Diabetic nephropathy (DN) is one of the microvascular complications of both type 1 and type 2 diabetes, which is also associated with a poor life expectancy of diabetic patients. However, the pathogenesis of DN is still unclear. Thus, it is of great use to establish appropriate animal models of DN for doing research on pathogenesis and developing novel therapeutic strategies. Although a large number of murine models of DN including artificially induced, spontaneous, and genetically engineered (knockout and transgenic) animal models have been developed, none of them develops renal changes sufficiently reflecting those seen in humans. Here we review the identified murine models of DN from the aspects of genetic background, type of diabetes, method of induction, gene deficiency, animal age and gender, kidney histopathology, and phenotypic alterations in the hope of enhancing our comprehension of genetic susceptibility and molecular mechanisms responsible for this disease and providing new clues as to how to choose appropriate animal models of DN. |
| format | Article |
| id | doaj-art-b7b48baae0e14dbc8a6eb4c40ded4fbf |
| institution | Kabale University |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-b7b48baae0e14dbc8a6eb4c40ded4fbf2025-02-03T05:51:32ZengWileyJournal of Diabetes Research2314-67452314-67532013-01-01201310.1155/2013/797548797548Advances in Murine Models of Diabetic NephropathyLi-li Kong0Hao Wu1Wen-peng Cui2Wen-hua Zhou3Ping Luo4Jing Sun5Hang Yuan6Li-ning Miao7Department of Nephrology, The Second Hospital of Jilin University, Changchun 130041, ChinaDepartment of Nephrology, The Second Hospital of Jilin University, Changchun 130041, ChinaDepartment of Nephrology, The Second Hospital of Jilin University, Changchun 130041, ChinaDepartment of Nephrology, The Second Hospital of Jilin University, Changchun 130041, ChinaDepartment of Nephrology, The Second Hospital of Jilin University, Changchun 130041, ChinaDepartment of Nephrology, The Second Hospital of Jilin University, Changchun 130041, ChinaDepartment of Nephrology, The Second Hospital of Jilin University, Changchun 130041, ChinaDepartment of Nephrology, The Second Hospital of Jilin University, Changchun 130041, ChinaDiabetic nephropathy (DN) is one of the microvascular complications of both type 1 and type 2 diabetes, which is also associated with a poor life expectancy of diabetic patients. However, the pathogenesis of DN is still unclear. Thus, it is of great use to establish appropriate animal models of DN for doing research on pathogenesis and developing novel therapeutic strategies. Although a large number of murine models of DN including artificially induced, spontaneous, and genetically engineered (knockout and transgenic) animal models have been developed, none of them develops renal changes sufficiently reflecting those seen in humans. Here we review the identified murine models of DN from the aspects of genetic background, type of diabetes, method of induction, gene deficiency, animal age and gender, kidney histopathology, and phenotypic alterations in the hope of enhancing our comprehension of genetic susceptibility and molecular mechanisms responsible for this disease and providing new clues as to how to choose appropriate animal models of DN.http://dx.doi.org/10.1155/2013/797548 |
| spellingShingle | Li-li Kong Hao Wu Wen-peng Cui Wen-hua Zhou Ping Luo Jing Sun Hang Yuan Li-ning Miao Advances in Murine Models of Diabetic Nephropathy Journal of Diabetes Research |
| title | Advances in Murine Models of Diabetic Nephropathy |
| title_full | Advances in Murine Models of Diabetic Nephropathy |
| title_fullStr | Advances in Murine Models of Diabetic Nephropathy |
| title_full_unstemmed | Advances in Murine Models of Diabetic Nephropathy |
| title_short | Advances in Murine Models of Diabetic Nephropathy |
| title_sort | advances in murine models of diabetic nephropathy |
| url | http://dx.doi.org/10.1155/2013/797548 |
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