Seroprevalence and Biomarkers Detection of Human Herpes Virus (HHV-8) in Patients with Kaposi Sarcoma
Kaposi's sarcoma (KS) represents the most prevalent malignancy among untreated HIV-positive individuals. Herpesvirus linked with Kaposi's sarcoma (KSHV; also termed as human herpesvirus 8 (HHV8)). In this study, blood samples were collected from 120 individuals, 60 of them had HHV-8 infec...
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middle technical university
2023-06-01
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| Series: | Journal of Techniques |
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| Online Access: | https://journal.mtu.edu.iq/index.php/MTU/article/view/857 |
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| author | Abdulrazzaq Neamah Zghair Sumayah Faruq Kasim Nazar Sh. Mohammed Anil K. Sharma |
| author_facet | Abdulrazzaq Neamah Zghair Sumayah Faruq Kasim Nazar Sh. Mohammed Anil K. Sharma |
| author_sort | Abdulrazzaq Neamah Zghair |
| collection | DOAJ |
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Kaposi's sarcoma (KS) represents the most prevalent malignancy among untreated HIV-positive individuals. Herpesvirus linked with Kaposi's sarcoma (KSHV; also termed as human herpesvirus 8 (HHV8)). In this study, blood samples were collected from 120 individuals, 60 of them had HHV-8 infection with kaposi sarcoma and 60 persons as apparently healthy control. These patients attended Baghdad Teaching Hospital from the period of 15th February 2021 to 15th January 2022.
Infections are seen to be more prevalent in the age group of 25-49 years when compared to other groups. The distribution of the biomarkers confirmed that 50, 25 and 80% of the 20 infected patients were positive for Ca19.9, Ca125 and Ca15.3 respectively. The Ca19.9, Ca125, and Ca15.3 biomarkers all produced good results in patients with Human Herpes Virus 8 (HHV-8) infections, leading us to the conclusion that these biomarkers gave favorable results. All of the PCR products showed a positive amplification at 434bp. Phylogenetic analysis confirmed the belongingness to the HHV strain. Further, this could lead to the development of a novel molecular diagnostic tool.
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| format | Article |
| id | doaj-art-b7ac11b0ef4b4026908b74c9e5749dad |
| institution | Kabale University |
| issn | 1818-653X 2708-8383 |
| language | English |
| publishDate | 2023-06-01 |
| publisher | middle technical university |
| record_format | Article |
| series | Journal of Techniques |
| spelling | doaj-art-b7ac11b0ef4b4026908b74c9e5749dad2025-01-19T11:01:53Zengmiddle technical universityJournal of Techniques1818-653X2708-83832023-06-015210.51173/jt.v5i2.857Seroprevalence and Biomarkers Detection of Human Herpes Virus (HHV-8) in Patients with Kaposi SarcomaAbdulrazzaq Neamah Zghair0Sumayah Faruq Kasim1Nazar Sh. Mohammed2Anil K. Sharma3College of Health & Medical Technology - Baghdad, Middle Technical University, Baghdad, IraqCollege of Health & Medical Technology - Baghdad, Middle Technical University, Baghdad, IraqCollege of Health & Medical Technology - Baghdad, Middle Technical University, Baghdad, IraqMaharishi Markandeshwar University, Mullana-Ambala (Haryana), India Kaposi's sarcoma (KS) represents the most prevalent malignancy among untreated HIV-positive individuals. Herpesvirus linked with Kaposi's sarcoma (KSHV; also termed as human herpesvirus 8 (HHV8)). In this study, blood samples were collected from 120 individuals, 60 of them had HHV-8 infection with kaposi sarcoma and 60 persons as apparently healthy control. These patients attended Baghdad Teaching Hospital from the period of 15th February 2021 to 15th January 2022. Infections are seen to be more prevalent in the age group of 25-49 years when compared to other groups. The distribution of the biomarkers confirmed that 50, 25 and 80% of the 20 infected patients were positive for Ca19.9, Ca125 and Ca15.3 respectively. The Ca19.9, Ca125, and Ca15.3 biomarkers all produced good results in patients with Human Herpes Virus 8 (HHV-8) infections, leading us to the conclusion that these biomarkers gave favorable results. All of the PCR products showed a positive amplification at 434bp. Phylogenetic analysis confirmed the belongingness to the HHV strain. Further, this could lead to the development of a novel molecular diagnostic tool. https://journal.mtu.edu.iq/index.php/MTU/article/view/857BiomarkersHuman Herpes Virus(HHV-8)Sarcoma |
| spellingShingle | Abdulrazzaq Neamah Zghair Sumayah Faruq Kasim Nazar Sh. Mohammed Anil K. Sharma Seroprevalence and Biomarkers Detection of Human Herpes Virus (HHV-8) in Patients with Kaposi Sarcoma Journal of Techniques Biomarkers Human Herpes Virus (HHV-8) Sarcoma |
| title | Seroprevalence and Biomarkers Detection of Human Herpes Virus (HHV-8) in Patients with Kaposi Sarcoma |
| title_full | Seroprevalence and Biomarkers Detection of Human Herpes Virus (HHV-8) in Patients with Kaposi Sarcoma |
| title_fullStr | Seroprevalence and Biomarkers Detection of Human Herpes Virus (HHV-8) in Patients with Kaposi Sarcoma |
| title_full_unstemmed | Seroprevalence and Biomarkers Detection of Human Herpes Virus (HHV-8) in Patients with Kaposi Sarcoma |
| title_short | Seroprevalence and Biomarkers Detection of Human Herpes Virus (HHV-8) in Patients with Kaposi Sarcoma |
| title_sort | seroprevalence and biomarkers detection of human herpes virus hhv 8 in patients with kaposi sarcoma |
| topic | Biomarkers Human Herpes Virus (HHV-8) Sarcoma |
| url | https://journal.mtu.edu.iq/index.php/MTU/article/view/857 |
| work_keys_str_mv | AT abdulrazzaqneamahzghair seroprevalenceandbiomarkersdetectionofhumanherpesvirushhv8inpatientswithkaposisarcoma AT sumayahfaruqkasim seroprevalenceandbiomarkersdetectionofhumanherpesvirushhv8inpatientswithkaposisarcoma AT nazarshmohammed seroprevalenceandbiomarkersdetectionofhumanherpesvirushhv8inpatientswithkaposisarcoma AT anilksharma seroprevalenceandbiomarkersdetectionofhumanherpesvirushhv8inpatientswithkaposisarcoma |