Enhanced anti−tumor efficacy of “IL−15 and CCL19” −secreting CAR−T cells in human glioblastoma orthotopic xenograft model

Enhanced anti−tumor efficacy of “IL−15 and CCL19” −secreting CAR−T cells in human glioblastoma orthotopic xenograft model

Despite the remarkable success of CAR-T cell therapy in hematologic malignancies, its progress in solid tumors has been slow. Overcoming challenges such as the recruitment and infiltration of CAR-T cells into the tumor site and the survival issues in the harsh tumor microenvironment are crucial for...

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Bibliographic Details
Main Authors: Wanqiong Chen, Limian Hong, Shaomei Lin, Na Xian, Cailing Yan, Ningning Zhao, Yonglei Xiao, Wanting Liao, Yuxiang Huang, Mingzhu Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-03-01
Series:Frontiers in Oncology
Subjects:
CAR-T cells
glioblastoma
IL-15
CCL19
cancer immunotherapy
EGFRv III
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2025.1539055/full
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