Effect of Inhibition of Angiotensin-Converting Enzyme and/or Neutral Endopeptidase on Neuropathy in High-Fat-Fed C57Bl/6J Mice

Effect of Inhibition of Angiotensin-Converting Enzyme and/or Neutral Endopeptidase on Neuropathy in High-Fat-Fed C57Bl/6J Mice

We have demonstrated that treating diet-induced obese (DIO) mice with the vasopeptidase inhibitor ilepatril improved neural function. Vasopeptidase inhibitors block angiotensin-converting enzyme (ACE) and neutral endopeptidase (NEP) activity. We propose that increased activity of ACE and NEP contrib...

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Bibliographic Details
Main Authors: Lawrence Coppey, Bao Lu, Craig Gerard, Mark A. Yorek
Format: Article
Language:English
Published: Wiley 2012-01-01
Series:Journal of Obesity
Online Access:http://dx.doi.org/10.1155/2012/326806
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