(Pro)renin Receptor in Kidney Development and Disease
The renin-angiotensin system (RAS), a key regulator of the blood pressure and fluid/electrolyte homeostasis, also plays a critical role in kidney development. All the components of the RAS are expressed in the developing metanephros. Moreover, mutations in the genes encoding components of the RAS in...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2011-01-01
|
| Series: | International Journal of Nephrology |
| Online Access: | http://dx.doi.org/10.4061/2011/247048 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832561067512823808 |
|---|---|
| author | Renfang Song Ihor V. Yosypiv |
| author_facet | Renfang Song Ihor V. Yosypiv |
| author_sort | Renfang Song |
| collection | DOAJ |
| description | The renin-angiotensin system (RAS), a key regulator of the blood pressure and fluid/electrolyte homeostasis, also plays a critical role in kidney development. All the components of the RAS are expressed in the developing metanephros. Moreover, mutations in the genes encoding components of the RAS in mice or humans are associated with a broad spectrum of congenital anomalies of the kidney and urinary tract (CAKUT). These forms of CAKUT include renal papillary hypoplasia, hydronephrosis, duplicated collecting system, renal tubular dysgenesis, renal vascular abnormalities, and aberrant glomerulogenesis. Emerging evidence indicates that (pro)renin receptor (PRR), a novel component of the RAS, is essential for proper kidney development and that aberrant PRR signaling is causally linked to cardiovascular and renal disease. This paper describes the role of the RAS in kidney development and highlights emerging insights into the cellular and molecular mechanisms by which the PRR may regulate this critical morphogenetic process. |
| format | Article |
| id | doaj-art-b79a3687e94d4c8187d1e6e600dab5ff |
| institution | Kabale University |
| issn | 2090-214X 2090-2158 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Nephrology |
| spelling | doaj-art-b79a3687e94d4c8187d1e6e600dab5ff2025-02-03T01:26:03ZengWileyInternational Journal of Nephrology2090-214X2090-21582011-01-01201110.4061/2011/247048247048(Pro)renin Receptor in Kidney Development and DiseaseRenfang Song0Ihor V. Yosypiv1Section of Pediatric Nephrology, Department of Pediatrics, Hypertension and Renal Center of Excellence, Tulane University Health Sciences Center, 1430 Tulane Avenue, New Orleans, LA 70112, USASection of Pediatric Nephrology, Department of Pediatrics, Hypertension and Renal Center of Excellence, Tulane University Health Sciences Center, 1430 Tulane Avenue, New Orleans, LA 70112, USAThe renin-angiotensin system (RAS), a key regulator of the blood pressure and fluid/electrolyte homeostasis, also plays a critical role in kidney development. All the components of the RAS are expressed in the developing metanephros. Moreover, mutations in the genes encoding components of the RAS in mice or humans are associated with a broad spectrum of congenital anomalies of the kidney and urinary tract (CAKUT). These forms of CAKUT include renal papillary hypoplasia, hydronephrosis, duplicated collecting system, renal tubular dysgenesis, renal vascular abnormalities, and aberrant glomerulogenesis. Emerging evidence indicates that (pro)renin receptor (PRR), a novel component of the RAS, is essential for proper kidney development and that aberrant PRR signaling is causally linked to cardiovascular and renal disease. This paper describes the role of the RAS in kidney development and highlights emerging insights into the cellular and molecular mechanisms by which the PRR may regulate this critical morphogenetic process.http://dx.doi.org/10.4061/2011/247048 |
| spellingShingle | Renfang Song Ihor V. Yosypiv (Pro)renin Receptor in Kidney Development and Disease International Journal of Nephrology |
| title | (Pro)renin Receptor in Kidney Development and Disease |
| title_full | (Pro)renin Receptor in Kidney Development and Disease |
| title_fullStr | (Pro)renin Receptor in Kidney Development and Disease |
| title_full_unstemmed | (Pro)renin Receptor in Kidney Development and Disease |
| title_short | (Pro)renin Receptor in Kidney Development and Disease |
| title_sort | pro renin receptor in kidney development and disease |
| url | http://dx.doi.org/10.4061/2011/247048 |
| work_keys_str_mv | AT renfangsong proreninreceptorinkidneydevelopmentanddisease AT ihorvyosypiv proreninreceptorinkidneydevelopmentanddisease |