Placental Growth Factor, Soluble fms-Like Tyrosine Kinase 1, Soluble Endoglin, IL-6, and IL-16 as Biomarkers in Preeclampsia
Preeclampsia (PE), an important cause of maternal and perinatal morbidity and mortality worldwide, is a pregnancy-related disease characterized by hypertension and proteinuria after 20 weeks of gestation. The aim of our study was to find a practical panel of biomarkers useful in early diagnosis of P...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2016/3027363 |
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| author | Carmen Rădulescu Anca Bacârea Adina Huțanu Rozalia Gabor Minodora Dobreanu |
| author_facet | Carmen Rădulescu Anca Bacârea Adina Huțanu Rozalia Gabor Minodora Dobreanu |
| author_sort | Carmen Rădulescu |
| collection | DOAJ |
| description | Preeclampsia (PE), an important cause of maternal and perinatal morbidity and mortality worldwide, is a pregnancy-related disease characterized by hypertension and proteinuria after 20 weeks of gestation. The aim of our study was to find a practical panel of biomarkers useful in early diagnosis of PE. This study was carried out at the Obstetrics and Gynecology Department in Tîrgu Mureș University Hospital, Romania, between January 2014 and July 2015 and included 68 pregnant women (47 preeclamptic women and 21 controls) with gestational age between 16 and 20 weeks at enrollment. The biomarkers PlGF, sFlt-1, sEng, IL-6, and IL-16 were determined by ELISA test. We compared the serum levels of soluble markers analysed in preeclamptic women and controls during the second and third trimesters of pregnancy and we found that the best predictor for PE was PlGF with a sensitivity of 100% at a concentration threshold of 120.16 pg/mL, a diagnosis accuracy of 70.8%, and AUC of 0.684 (p=0.005). We also estimated the risk for PE according to BMI and we found that pregnant women with weight >90 kg had 7 times higher risk for PE. Second-trimester PlGF serum level may serve as an early biomarker for the diagnosis of PE. |
| format | Article |
| id | doaj-art-b797f634ec4e4e25aa7626431cd76d62 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-b797f634ec4e4e25aa7626431cd76d622025-02-03T01:25:53ZengWileyMediators of Inflammation0962-93511466-18612016-01-01201610.1155/2016/30273633027363Placental Growth Factor, Soluble fms-Like Tyrosine Kinase 1, Soluble Endoglin, IL-6, and IL-16 as Biomarkers in PreeclampsiaCarmen Rădulescu0Anca Bacârea1Adina Huțanu2Rozalia Gabor3Minodora Dobreanu4Department of Obstetrics and Gynecology II, University of Medicine and Pharmacy of Tîrgu Mureș, Târgu Mureș, RomaniaDepartment of Pathophysiology, University of Medicine and Pharmacy of Tîrgu Mureș, Târgu Mureș, RomaniaCCAMF of University of Medicine and Pharmacy of Tîrgu Mureș, Târgu Mureș, RomaniaDepartment of Management and Economy, University Petru Maior of Tîrgu Mureș, Târgu Mureș, RomaniaCCAMF of University of Medicine and Pharmacy of Tîrgu Mureș, Târgu Mureș, RomaniaPreeclampsia (PE), an important cause of maternal and perinatal morbidity and mortality worldwide, is a pregnancy-related disease characterized by hypertension and proteinuria after 20 weeks of gestation. The aim of our study was to find a practical panel of biomarkers useful in early diagnosis of PE. This study was carried out at the Obstetrics and Gynecology Department in Tîrgu Mureș University Hospital, Romania, between January 2014 and July 2015 and included 68 pregnant women (47 preeclamptic women and 21 controls) with gestational age between 16 and 20 weeks at enrollment. The biomarkers PlGF, sFlt-1, sEng, IL-6, and IL-16 were determined by ELISA test. We compared the serum levels of soluble markers analysed in preeclamptic women and controls during the second and third trimesters of pregnancy and we found that the best predictor for PE was PlGF with a sensitivity of 100% at a concentration threshold of 120.16 pg/mL, a diagnosis accuracy of 70.8%, and AUC of 0.684 (p=0.005). We also estimated the risk for PE according to BMI and we found that pregnant women with weight >90 kg had 7 times higher risk for PE. Second-trimester PlGF serum level may serve as an early biomarker for the diagnosis of PE.http://dx.doi.org/10.1155/2016/3027363 |
| spellingShingle | Carmen Rădulescu Anca Bacârea Adina Huțanu Rozalia Gabor Minodora Dobreanu Placental Growth Factor, Soluble fms-Like Tyrosine Kinase 1, Soluble Endoglin, IL-6, and IL-16 as Biomarkers in Preeclampsia Mediators of Inflammation |
| title | Placental Growth Factor, Soluble fms-Like Tyrosine Kinase 1, Soluble Endoglin, IL-6, and IL-16 as Biomarkers in Preeclampsia |
| title_full | Placental Growth Factor, Soluble fms-Like Tyrosine Kinase 1, Soluble Endoglin, IL-6, and IL-16 as Biomarkers in Preeclampsia |
| title_fullStr | Placental Growth Factor, Soluble fms-Like Tyrosine Kinase 1, Soluble Endoglin, IL-6, and IL-16 as Biomarkers in Preeclampsia |
| title_full_unstemmed | Placental Growth Factor, Soluble fms-Like Tyrosine Kinase 1, Soluble Endoglin, IL-6, and IL-16 as Biomarkers in Preeclampsia |
| title_short | Placental Growth Factor, Soluble fms-Like Tyrosine Kinase 1, Soluble Endoglin, IL-6, and IL-16 as Biomarkers in Preeclampsia |
| title_sort | placental growth factor soluble fms like tyrosine kinase 1 soluble endoglin il 6 and il 16 as biomarkers in preeclampsia |
| url | http://dx.doi.org/10.1155/2016/3027363 |
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