Effect of Several Naja atra Antivenom Injection Methods on the Rabbit Model of Naja naja atra Bite Poisoning
Snakebite is a global public health concern, which often occurs in tropical and subtropical underdeveloped areas, but it is often neglected. In the southern China, Naja naja atra (Chinese cobra) is a common venomous snake that causes swelling and necrosis of local tissues, even amputation and death....
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| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-01-01
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| Series: | Journal of Tropical Medicine |
| Online Access: | http://dx.doi.org/10.1155/2023/3253771 |
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| author | Jie Yang Jin-Cheng Li Zhou Huang Dong-Ling Huang Fan Wang Wan-Xia Wei Ji-Fei Nong Feng Yang Xue-Ling Lu Jun-Rong Zhu Wei Wang |
| author_facet | Jie Yang Jin-Cheng Li Zhou Huang Dong-Ling Huang Fan Wang Wan-Xia Wei Ji-Fei Nong Feng Yang Xue-Ling Lu Jun-Rong Zhu Wei Wang |
| author_sort | Jie Yang |
| collection | DOAJ |
| description | Snakebite is a global public health concern, which often occurs in tropical and subtropical underdeveloped areas, but it is often neglected. In the southern China, Naja naja atra (Chinese cobra) is a common venomous snake that causes swelling and necrosis of local tissues, even amputation and death. Currently, the main therapy is the administration of Naja atra antivenom, which greatly reduces mortality. However, the antivenom is not particularly effective in the improvement of local tissue necrosis. Clinically, antivenom is mainly administered intravenously. We speculated that the method of injection influences the efficacy of antivenom. In this study, the rabbit model was used to explore the effects of different antivenom injection methods on systemic and local poisoning symptoms. If topical injection of antivenom contributes to ameliorate tissue necrosis, then we need to reconsider the use of Naja atra antivenom. |
| format | Article |
| id | doaj-art-b787eb8414de4f07b520e87bb9095741 |
| institution | Kabale University |
| issn | 1687-9694 |
| language | English |
| publishDate | 2023-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Tropical Medicine |
| spelling | doaj-art-b787eb8414de4f07b520e87bb90957412025-02-03T06:42:38ZengWileyJournal of Tropical Medicine1687-96942023-01-01202310.1155/2023/3253771Effect of Several Naja atra Antivenom Injection Methods on the Rabbit Model of Naja naja atra Bite PoisoningJie Yang0Jin-Cheng Li1Zhou Huang2Dong-Ling Huang3Fan Wang4Wan-Xia Wei5Ji-Fei Nong6Feng Yang7Xue-Ling Lu8Jun-Rong Zhu9Wei Wang10Department of EmergencyDepartment of EmergencyDepartment of EmergencyDepartment of EmergencyDepartment of EmergencyDepartment of EmergencyDepartment of EmergencyDepartment of EmergencyDepartment of EmergencyDepartment of EmergencyDepartment of EmergencySnakebite is a global public health concern, which often occurs in tropical and subtropical underdeveloped areas, but it is often neglected. In the southern China, Naja naja atra (Chinese cobra) is a common venomous snake that causes swelling and necrosis of local tissues, even amputation and death. Currently, the main therapy is the administration of Naja atra antivenom, which greatly reduces mortality. However, the antivenom is not particularly effective in the improvement of local tissue necrosis. Clinically, antivenom is mainly administered intravenously. We speculated that the method of injection influences the efficacy of antivenom. In this study, the rabbit model was used to explore the effects of different antivenom injection methods on systemic and local poisoning symptoms. If topical injection of antivenom contributes to ameliorate tissue necrosis, then we need to reconsider the use of Naja atra antivenom.http://dx.doi.org/10.1155/2023/3253771 |
| spellingShingle | Jie Yang Jin-Cheng Li Zhou Huang Dong-Ling Huang Fan Wang Wan-Xia Wei Ji-Fei Nong Feng Yang Xue-Ling Lu Jun-Rong Zhu Wei Wang Effect of Several Naja atra Antivenom Injection Methods on the Rabbit Model of Naja naja atra Bite Poisoning Journal of Tropical Medicine |
| title | Effect of Several Naja atra Antivenom Injection Methods on the Rabbit Model of Naja naja atra Bite Poisoning |
| title_full | Effect of Several Naja atra Antivenom Injection Methods on the Rabbit Model of Naja naja atra Bite Poisoning |
| title_fullStr | Effect of Several Naja atra Antivenom Injection Methods on the Rabbit Model of Naja naja atra Bite Poisoning |
| title_full_unstemmed | Effect of Several Naja atra Antivenom Injection Methods on the Rabbit Model of Naja naja atra Bite Poisoning |
| title_short | Effect of Several Naja atra Antivenom Injection Methods on the Rabbit Model of Naja naja atra Bite Poisoning |
| title_sort | effect of several naja atra antivenom injection methods on the rabbit model of naja naja atra bite poisoning |
| url | http://dx.doi.org/10.1155/2023/3253771 |
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