Successful resection of a neuroendocrine tumor in the gallbladder: a case report
Abstract Background Gallbladder neuroendocrine tumors (GB-NETs) are extremely rare, representing only 0.5% of all NETs because no neuroectodermal cells are present in the gallbladder. In 2019, the World Health Organization updated the classification of NETs based on their molecular differences. The...
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Japan Surgical Society
2020-10-01
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| Series: | Surgical Case Reports |
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| Online Access: | http://link.springer.com/article/10.1186/s40792-020-01055-w |
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| author | Hideo Tomihara Kazuhiko Hashimoto Tomoko Wakasa Hajime Ishikawa Tomoyuki Tsujimoto Atsushi Gakuhara Shuichi Fukuda Katsuya Ohta Kotaro Kitani Jin-ichi Hida Yoshio Ohta Masao Yukawa |
| author_facet | Hideo Tomihara Kazuhiko Hashimoto Tomoko Wakasa Hajime Ishikawa Tomoyuki Tsujimoto Atsushi Gakuhara Shuichi Fukuda Katsuya Ohta Kotaro Kitani Jin-ichi Hida Yoshio Ohta Masao Yukawa |
| author_sort | Hideo Tomihara |
| collection | DOAJ |
| description | Abstract Background Gallbladder neuroendocrine tumors (GB-NETs) are extremely rare, representing only 0.5% of all NETs because no neuroectodermal cells are present in the gallbladder. In 2019, the World Health Organization updated the classification of NETs based on their molecular differences. The mutation status of DAXX and ATRX has been added to the criteria for well-differentiated NETs. Case presentation A 50-year-old man presented to our hospital for further examination of a gallbladder polyp. He had no right quadrant pain, fever, jaundice, weight loss, or carcinoid syndrome-related symptoms. The patient hoped to avoid cholecystectomy. During the 3-year observation period, the polyp gradually increased in size from 8.3 to 9.9 mm. He decided to undergo surgery, and whole cholecystectomy was successfully performed. Immunohistochemical staining revealed positivity for chromogranin A, synaptophysin, and CD56. The Ki-67 index was < 3%. Taken together, these results led to a diagnosis of a grade 1 GB-NET. We also performed immunohistochemical staining of DAXX and ATRX, which revealed that DAXX protein expression was negative. The patient’s postoperative course was uneventful, and he developed no recurrence for 8 years after surgery. Conclusion We experienced a very rare case of GB-NET. Obtaining a correct preoperative diagnosis is quite difficult at the first evaluation. A GB-NET should be considered as a differential diagnosis of gallbladder tumors. |
| format | Article |
| id | doaj-art-b775d0fdae8041fbbbf3b55f917aba52 |
| institution | Kabale University |
| issn | 2198-7793 |
| language | English |
| publishDate | 2020-10-01 |
| publisher | Japan Surgical Society |
| record_format | Article |
| series | Surgical Case Reports |
| spelling | doaj-art-b775d0fdae8041fbbbf3b55f917aba522025-08-20T03:38:40ZengJapan Surgical SocietySurgical Case Reports2198-77932020-10-01611610.1186/s40792-020-01055-wSuccessful resection of a neuroendocrine tumor in the gallbladder: a case reportHideo Tomihara0Kazuhiko Hashimoto1Tomoko Wakasa2Hajime Ishikawa3Tomoyuki Tsujimoto4Atsushi Gakuhara5Shuichi Fukuda6Katsuya Ohta7Kotaro Kitani8Jin-ichi Hida9Yoshio Ohta10Masao Yukawa11Department of Surgery, Kindai University Nara HospitalDepartment of Surgery, Kindai University Nara HospitalDepartment of Pathology and Laboratory, Kindai University Nara HospitalDepartment of Surgery, Kindai University Nara HospitalDepartment of Surgery, Kindai University Nara HospitalDepartment of Surgery, Kindai University Nara HospitalDepartment of Surgery, Kindai University Nara HospitalDepartment of Surgery, Kindai University Nara HospitalDepartment of Surgery, Kindai University Nara HospitalDepartment of Surgery, Kindai University Nara HospitalDepartment of Pathology and Laboratory, Kindai University Nara HospitalDepartment of Surgery, Kindai University Nara HospitalAbstract Background Gallbladder neuroendocrine tumors (GB-NETs) are extremely rare, representing only 0.5% of all NETs because no neuroectodermal cells are present in the gallbladder. In 2019, the World Health Organization updated the classification of NETs based on their molecular differences. The mutation status of DAXX and ATRX has been added to the criteria for well-differentiated NETs. Case presentation A 50-year-old man presented to our hospital for further examination of a gallbladder polyp. He had no right quadrant pain, fever, jaundice, weight loss, or carcinoid syndrome-related symptoms. The patient hoped to avoid cholecystectomy. During the 3-year observation period, the polyp gradually increased in size from 8.3 to 9.9 mm. He decided to undergo surgery, and whole cholecystectomy was successfully performed. Immunohistochemical staining revealed positivity for chromogranin A, synaptophysin, and CD56. The Ki-67 index was < 3%. Taken together, these results led to a diagnosis of a grade 1 GB-NET. We also performed immunohistochemical staining of DAXX and ATRX, which revealed that DAXX protein expression was negative. The patient’s postoperative course was uneventful, and he developed no recurrence for 8 years after surgery. Conclusion We experienced a very rare case of GB-NET. Obtaining a correct preoperative diagnosis is quite difficult at the first evaluation. A GB-NET should be considered as a differential diagnosis of gallbladder tumors.http://link.springer.com/article/10.1186/s40792-020-01055-wGallbladderNeuroendocrine tumorCarcinoid |
| spellingShingle | Hideo Tomihara Kazuhiko Hashimoto Tomoko Wakasa Hajime Ishikawa Tomoyuki Tsujimoto Atsushi Gakuhara Shuichi Fukuda Katsuya Ohta Kotaro Kitani Jin-ichi Hida Yoshio Ohta Masao Yukawa Successful resection of a neuroendocrine tumor in the gallbladder: a case report Surgical Case Reports Gallbladder Neuroendocrine tumor Carcinoid |
| title | Successful resection of a neuroendocrine tumor in the gallbladder: a case report |
| title_full | Successful resection of a neuroendocrine tumor in the gallbladder: a case report |
| title_fullStr | Successful resection of a neuroendocrine tumor in the gallbladder: a case report |
| title_full_unstemmed | Successful resection of a neuroendocrine tumor in the gallbladder: a case report |
| title_short | Successful resection of a neuroendocrine tumor in the gallbladder: a case report |
| title_sort | successful resection of a neuroendocrine tumor in the gallbladder a case report |
| topic | Gallbladder Neuroendocrine tumor Carcinoid |
| url | http://link.springer.com/article/10.1186/s40792-020-01055-w |
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