Crude Ethanol Extract of Diospyros mespiliformis Hochst. ex A. DC. Ebenaceae Leaf and Its Fractions Ameliorate Hyperglycemia and Hyperlipidemia in Alloxan-induced Diabetic Rats
This study investigated the antidiabetic activity of the crude ethanol extract of Diospyros mespiliformis (DM) and its ethyl acetate (EEF) and aqueous (AQF) fractions on alloxan-induced diabetic rats. The result indicated a significant (p < 0.05) decrease and improvement in fasting blood glucose...
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Mulawarman University
2024-12-01
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| Series: | Journal of Tropical Pharmacy and Chemistry |
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| Online Access: | https://jtpc.jurnalfamul.com/index.php/jtpc/article/view/625 |
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| author | Mubarak Muhammad Dahiru Neksumi Musa |
| author_facet | Mubarak Muhammad Dahiru Neksumi Musa |
| author_sort | Mubarak Muhammad Dahiru |
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This study investigated the antidiabetic activity of the crude ethanol extract of Diospyros mespiliformis (DM) and its ethyl acetate (EEF) and aqueous (AQF) fractions on alloxan-induced diabetic rats. The result indicated a significant (p < 0.05) decrease and improvement in fasting blood glucose (FBG) level and body weight, respectively. The treatment groups exhibited a significantly (p < 0.05) decreased aspartate aminotransferase (AST) level (100-117 IU/L) and decreased gamma-glutamyl transferase (GGT) level in the EEF (4.80 ± 1.02 IU/L) and AQF (5.80 ± 0.80 IU/L) groups only. All the extract-treated groups exhibited a significant increase (p < 0.05) in urea and creatinine levels than the naïve control group (6.94 ± 0.20 mM/L). Moreover, the Na+ remained significantly (p > 0.05) unchanged while the K+ level was significantly (p < 0.05) increased for the treatment groups. The HCO3- of the treated groups increased significantly (p < 0.05) except for the AQF (21.60 ± 1.63 mM/L) group. The total cholesterol and triglyceride levels decreased significantly (p < 0.05) for the treatment groups while the high-density lipoprotein-cholesterol (HDL-C) and low-density lipoprotein-cholesterol (LDL-C) levels remained unchanged but significantly higher than the metformin group. DM possesses significant hypoglycemic and hypolipidemic activity lowering hyperglycemia and hyperlipidemia, and improving body weight and diabetic markers.
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| format | Article |
| id | doaj-art-b767613978ca4cc88e5934f7ca91a65e |
| institution | Kabale University |
| issn | 2087-7099 2407-6090 |
| language | English |
| publishDate | 2024-12-01 |
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| spelling | doaj-art-b767613978ca4cc88e5934f7ca91a65e2025-01-27T16:19:24ZengMulawarman UniversityJournal of Tropical Pharmacy and Chemistry2087-70992407-60902024-12-018210.25026/jtpc.v8i2.625Crude Ethanol Extract of Diospyros mespiliformis Hochst. ex A. DC. Ebenaceae Leaf and Its Fractions Ameliorate Hyperglycemia and Hyperlipidemia in Alloxan-induced Diabetic RatsMubarak Muhammad Dahiru0https://orcid.org/0000-0002-1252-3699Neksumi Musa1Adamawa State Polytechnic, School Science and Technology, Department of Pharmaceutical Technology, 640101, Yola, NigeriaAdamawa State Polytechnic, School Science and Technology, Department of Science Laboratory Technology, 640101, Yola, Nigeria This study investigated the antidiabetic activity of the crude ethanol extract of Diospyros mespiliformis (DM) and its ethyl acetate (EEF) and aqueous (AQF) fractions on alloxan-induced diabetic rats. The result indicated a significant (p < 0.05) decrease and improvement in fasting blood glucose (FBG) level and body weight, respectively. The treatment groups exhibited a significantly (p < 0.05) decreased aspartate aminotransferase (AST) level (100-117 IU/L) and decreased gamma-glutamyl transferase (GGT) level in the EEF (4.80 ± 1.02 IU/L) and AQF (5.80 ± 0.80 IU/L) groups only. All the extract-treated groups exhibited a significant increase (p < 0.05) in urea and creatinine levels than the naïve control group (6.94 ± 0.20 mM/L). Moreover, the Na+ remained significantly (p > 0.05) unchanged while the K+ level was significantly (p < 0.05) increased for the treatment groups. The HCO3- of the treated groups increased significantly (p < 0.05) except for the AQF (21.60 ± 1.63 mM/L) group. The total cholesterol and triglyceride levels decreased significantly (p < 0.05) for the treatment groups while the high-density lipoprotein-cholesterol (HDL-C) and low-density lipoprotein-cholesterol (LDL-C) levels remained unchanged but significantly higher than the metformin group. DM possesses significant hypoglycemic and hypolipidemic activity lowering hyperglycemia and hyperlipidemia, and improving body weight and diabetic markers. https://jtpc.jurnalfamul.com/index.php/jtpc/article/view/625AlloxanAntidiabetic activityDiospyros mespiliformisHypoglycemiaHypolipidemia |
| spellingShingle | Mubarak Muhammad Dahiru Neksumi Musa Crude Ethanol Extract of Diospyros mespiliformis Hochst. ex A. DC. Ebenaceae Leaf and Its Fractions Ameliorate Hyperglycemia and Hyperlipidemia in Alloxan-induced Diabetic Rats Journal of Tropical Pharmacy and Chemistry Alloxan Antidiabetic activity Diospyros mespiliformis Hypoglycemia Hypolipidemia |
| title | Crude Ethanol Extract of Diospyros mespiliformis Hochst. ex A. DC. Ebenaceae Leaf and Its Fractions Ameliorate Hyperglycemia and Hyperlipidemia in Alloxan-induced Diabetic Rats |
| title_full | Crude Ethanol Extract of Diospyros mespiliformis Hochst. ex A. DC. Ebenaceae Leaf and Its Fractions Ameliorate Hyperglycemia and Hyperlipidemia in Alloxan-induced Diabetic Rats |
| title_fullStr | Crude Ethanol Extract of Diospyros mespiliformis Hochst. ex A. DC. Ebenaceae Leaf and Its Fractions Ameliorate Hyperglycemia and Hyperlipidemia in Alloxan-induced Diabetic Rats |
| title_full_unstemmed | Crude Ethanol Extract of Diospyros mespiliformis Hochst. ex A. DC. Ebenaceae Leaf and Its Fractions Ameliorate Hyperglycemia and Hyperlipidemia in Alloxan-induced Diabetic Rats |
| title_short | Crude Ethanol Extract of Diospyros mespiliformis Hochst. ex A. DC. Ebenaceae Leaf and Its Fractions Ameliorate Hyperglycemia and Hyperlipidemia in Alloxan-induced Diabetic Rats |
| title_sort | crude ethanol extract of diospyros mespiliformis hochst ex a dc ebenaceae leaf and its fractions ameliorate hyperglycemia and hyperlipidemia in alloxan induced diabetic rats |
| topic | Alloxan Antidiabetic activity Diospyros mespiliformis Hypoglycemia Hypolipidemia |
| url | https://jtpc.jurnalfamul.com/index.php/jtpc/article/view/625 |
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