Vancomycin-Induced DRESS Syndrome: An Important Concern in Orthopedic Surgery
DRESS (drug reaction with eosinophilia and systemic symptoms) is a potentially serious complication when prolonged courses of antibiotics are given to patients, with an average onset of 2–6 weeks after commencement. There is a high mortality rate (1–10%). We report the case of a 62-year-old male who...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Case Reports in Orthopedics |
| Online Access: | http://dx.doi.org/10.1155/2018/1439073 |
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| _version_ | 1832556633635422208 |
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| author | Emma Littlehales Odhrán Murray Robert Dunsmuir |
| author_facet | Emma Littlehales Odhrán Murray Robert Dunsmuir |
| author_sort | Emma Littlehales |
| collection | DOAJ |
| description | DRESS (drug reaction with eosinophilia and systemic symptoms) is a potentially serious complication when prolonged courses of antibiotics are given to patients, with an average onset of 2–6 weeks after commencement. There is a high mortality rate (1–10%). We report the case of a 62-year-old male who developed DRESS after seven weeks of antibiotic treatment with vancomycin for a deep spinal metalwork infection. We describe the typical rash and biochemical results, including eosinophilia, as well as the systemic signs seen in this case. The criteria for diagnosis of DRESS, including the RegiSCAR scoring system and commonly affected systems (renal, cardiac, and hepatic), are detailed, and we also discuss evidence for steroid treatment and considerations important in the use of this. |
| format | Article |
| id | doaj-art-b7661a925aad4591b3a64af48117f765 |
| institution | Kabale University |
| issn | 2090-6749 2090-6757 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Orthopedics |
| spelling | doaj-art-b7661a925aad4591b3a64af48117f7652025-02-03T05:44:55ZengWileyCase Reports in Orthopedics2090-67492090-67572018-01-01201810.1155/2018/14390731439073Vancomycin-Induced DRESS Syndrome: An Important Concern in Orthopedic SurgeryEmma Littlehales0Odhrán Murray1Robert Dunsmuir2Department of Orthopedic and Spinal Surgery, Leeds General Infirmary, Leeds, UKDepartment of Orthopedic and Spinal Surgery, Queen Elizabeth University Hospital, Glasgow, UKDepartment of Orthopedic and Spinal Surgery, Leeds General Infirmary, Leeds, UKDRESS (drug reaction with eosinophilia and systemic symptoms) is a potentially serious complication when prolonged courses of antibiotics are given to patients, with an average onset of 2–6 weeks after commencement. There is a high mortality rate (1–10%). We report the case of a 62-year-old male who developed DRESS after seven weeks of antibiotic treatment with vancomycin for a deep spinal metalwork infection. We describe the typical rash and biochemical results, including eosinophilia, as well as the systemic signs seen in this case. The criteria for diagnosis of DRESS, including the RegiSCAR scoring system and commonly affected systems (renal, cardiac, and hepatic), are detailed, and we also discuss evidence for steroid treatment and considerations important in the use of this.http://dx.doi.org/10.1155/2018/1439073 |
| spellingShingle | Emma Littlehales Odhrán Murray Robert Dunsmuir Vancomycin-Induced DRESS Syndrome: An Important Concern in Orthopedic Surgery Case Reports in Orthopedics |
| title | Vancomycin-Induced DRESS Syndrome: An Important Concern in Orthopedic Surgery |
| title_full | Vancomycin-Induced DRESS Syndrome: An Important Concern in Orthopedic Surgery |
| title_fullStr | Vancomycin-Induced DRESS Syndrome: An Important Concern in Orthopedic Surgery |
| title_full_unstemmed | Vancomycin-Induced DRESS Syndrome: An Important Concern in Orthopedic Surgery |
| title_short | Vancomycin-Induced DRESS Syndrome: An Important Concern in Orthopedic Surgery |
| title_sort | vancomycin induced dress syndrome an important concern in orthopedic surgery |
| url | http://dx.doi.org/10.1155/2018/1439073 |
| work_keys_str_mv | AT emmalittlehales vancomycininduceddresssyndromeanimportantconcerninorthopedicsurgery AT odhranmurray vancomycininduceddresssyndromeanimportantconcerninorthopedicsurgery AT robertdunsmuir vancomycininduceddresssyndromeanimportantconcerninorthopedicsurgery |