Effect of Collagen/Ibuprofen Hydrogel in Wound Healing: An In Vivo Study
Background and Aim. Wound healing is a complicated physiological process to preserve skin integrity after injuries and includes the proliferative phase, hemostasis/inflammatory phase, and remodeling through extracellular, intercellular, and intracellular components synchronization. The study aimed t...
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Advances in Materials Science and Engineering |
| Online Access: | http://dx.doi.org/10.1155/2022/6033815 |
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| author | Kamyar Abbasi Reza Eftekhar Ashtiani Mitra Abdolahi Maryam Hosseini Reza Sayyad Soufdoost Mostafa Alam Sadaf Fani-Hanifeh |
| author_facet | Kamyar Abbasi Reza Eftekhar Ashtiani Mitra Abdolahi Maryam Hosseini Reza Sayyad Soufdoost Mostafa Alam Sadaf Fani-Hanifeh |
| author_sort | Kamyar Abbasi |
| collection | DOAJ |
| description | Background and Aim. Wound healing is a complicated physiological process to preserve skin integrity after injuries and includes the proliferative phase, hemostasis/inflammatory phase, and remodeling through extracellular, intercellular, and intracellular components synchronization. The study aimed to examine human placental collagen/ibuprofen’s effect on wound healing in an animal model. Materials and Methods. The cell viability test was performed by MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide) assay. In this animal study, three circular excisions were made in the back of each of the 12 rats and injected with the following groups: collagen/ibuprofen, group 1; collagen, group 2; and unfilled as the control group, group 3 for two times. The healing procedures were explored via calculating wound contraction percentage after taking photographs on days 7 and 14. Also, histopathological assessments were conducted on days 7 and 14. Results. The MTT results showed no significant cytotoxicity, and macroscopic results demonstrated that the percentage of wound contraction was 85%, 79%, and 41% in the collagen/ibuprofen, collagen, and control groups on 14th day, respectively. Histopathological assessments showed that hair follicles number, fibroblasts content, and angiogenesis in the collagen/ibuprofen were remarkably more significant than collagen and control groups. Conclusion. The collagen/ibuprofen group had significant outcomes compared with collagen and the control groups in wound healing and wound contraction. Collagen/ibuprofen hydrogel can be a potential hydrogel in accelerating wound healing. |
| format | Article |
| id | doaj-art-b7636d42b80e481a88eca1ee34358975 |
| institution | Kabale University |
| issn | 1687-8442 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advances in Materials Science and Engineering |
| spelling | doaj-art-b7636d42b80e481a88eca1ee343589752025-02-03T10:59:55ZengWileyAdvances in Materials Science and Engineering1687-84422022-01-01202210.1155/2022/6033815Effect of Collagen/Ibuprofen Hydrogel in Wound Healing: An In Vivo StudyKamyar Abbasi0Reza Eftekhar Ashtiani1Mitra Abdolahi2Maryam Hosseini3Reza Sayyad Soufdoost4Mostafa Alam5Sadaf Fani-Hanifeh6Department of ProsthodonticsDepartment of ProsthodonticsDepartment of PathologySchool of DentistryDentistry Research InstituteDepartment of Oral and Maxillofacial SurgeryRajaie Cardiovascular Medical and Research CenterBackground and Aim. Wound healing is a complicated physiological process to preserve skin integrity after injuries and includes the proliferative phase, hemostasis/inflammatory phase, and remodeling through extracellular, intercellular, and intracellular components synchronization. The study aimed to examine human placental collagen/ibuprofen’s effect on wound healing in an animal model. Materials and Methods. The cell viability test was performed by MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide) assay. In this animal study, three circular excisions were made in the back of each of the 12 rats and injected with the following groups: collagen/ibuprofen, group 1; collagen, group 2; and unfilled as the control group, group 3 for two times. The healing procedures were explored via calculating wound contraction percentage after taking photographs on days 7 and 14. Also, histopathological assessments were conducted on days 7 and 14. Results. The MTT results showed no significant cytotoxicity, and macroscopic results demonstrated that the percentage of wound contraction was 85%, 79%, and 41% in the collagen/ibuprofen, collagen, and control groups on 14th day, respectively. Histopathological assessments showed that hair follicles number, fibroblasts content, and angiogenesis in the collagen/ibuprofen were remarkably more significant than collagen and control groups. Conclusion. The collagen/ibuprofen group had significant outcomes compared with collagen and the control groups in wound healing and wound contraction. Collagen/ibuprofen hydrogel can be a potential hydrogel in accelerating wound healing.http://dx.doi.org/10.1155/2022/6033815 |
| spellingShingle | Kamyar Abbasi Reza Eftekhar Ashtiani Mitra Abdolahi Maryam Hosseini Reza Sayyad Soufdoost Mostafa Alam Sadaf Fani-Hanifeh Effect of Collagen/Ibuprofen Hydrogel in Wound Healing: An In Vivo Study Advances in Materials Science and Engineering |
| title | Effect of Collagen/Ibuprofen Hydrogel in Wound Healing: An In Vivo Study |
| title_full | Effect of Collagen/Ibuprofen Hydrogel in Wound Healing: An In Vivo Study |
| title_fullStr | Effect of Collagen/Ibuprofen Hydrogel in Wound Healing: An In Vivo Study |
| title_full_unstemmed | Effect of Collagen/Ibuprofen Hydrogel in Wound Healing: An In Vivo Study |
| title_short | Effect of Collagen/Ibuprofen Hydrogel in Wound Healing: An In Vivo Study |
| title_sort | effect of collagen ibuprofen hydrogel in wound healing an in vivo study |
| url | http://dx.doi.org/10.1155/2022/6033815 |
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