Reversible Improvement of Arterial Stenosis and Wall Thickness in Takayasu Arteritis Through Treatment With Tocilizumab
Early diagnosis and initiation of treatment in Takayasu arteritis (TA) is important to prevent irreversible arterial changes. A 39-year-old female was diagnosed with active TA. Subcutaneous administration of tocilizumab (162 mg/week) was initiated in combination with prednisolone (30 mg/d). After 21...
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| Format: | Article |
| Language: | English |
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American College of Physicians
2022-11-01
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| Series: | Annals of Internal Medicine: Clinical Cases |
| Online Access: | https://www.acpjournals.org/doi/10.7326/aimcc.2022.0705 |
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| author | Shinichi Nogi Yusuke Yano Kako Kodama Hirotaka Tsuno Hideki Ogihara Masahiro Kawakami Tomoko Ohmori Shinji Sato Toshihiro Matsui |
| author_facet | Shinichi Nogi Yusuke Yano Kako Kodama Hirotaka Tsuno Hideki Ogihara Masahiro Kawakami Tomoko Ohmori Shinji Sato Toshihiro Matsui |
| author_sort | Shinichi Nogi |
| collection | DOAJ |
| description | Early diagnosis and initiation of treatment in Takayasu arteritis (TA) is important to prevent irreversible arterial changes. A 39-year-old female was diagnosed with active TA. Subcutaneous administration of tocilizumab (162 mg/week) was initiated in combination with prednisolone (30 mg/d). After 21 months, the carotid arterial stenosis and wall thickness had normalized with only slight plaque on echocardiography. After 23 months, computed tomography showed normalization of the overall aortic stenosis and wall thickness. The prednisolone dosage could be reduced to 2 mg/d without relapse for >2 years. Early combination treatment of TA with tocilizumab prevented and normalized vascular stenosis and wall thickness. |
| format | Article |
| id | doaj-art-b75f26d60f2843f28d381e34c6c4e2d4 |
| institution | OA Journals |
| issn | 2767-7664 |
| language | English |
| publishDate | 2022-11-01 |
| publisher | American College of Physicians |
| record_format | Article |
| series | Annals of Internal Medicine: Clinical Cases |
| spelling | doaj-art-b75f26d60f2843f28d381e34c6c4e2d42025-08-20T02:13:01ZengAmerican College of PhysiciansAnnals of Internal Medicine: Clinical Cases2767-76642022-11-011910.7326/aimcc.2022.0705Reversible Improvement of Arterial Stenosis and Wall Thickness in Takayasu Arteritis Through Treatment With TocilizumabShinichi Nogi0Yusuke Yano1Kako Kodama2Hirotaka Tsuno3Hideki Ogihara4Masahiro Kawakami5Tomoko Ohmori6Shinji Sato7Toshihiro Matsui81Department of Rheumatology, National Hospital Organization Sagamihara Hospital, Sagamihara, Kanagawa, Japan1Department of Rheumatology, National Hospital Organization Sagamihara Hospital, Sagamihara, Kanagawa, Japan1Department of Rheumatology, National Hospital Organization Sagamihara Hospital, Sagamihara, Kanagawa, Japan1Department of Rheumatology, National Hospital Organization Sagamihara Hospital, Sagamihara, Kanagawa, Japan1Department of Rheumatology, National Hospital Organization Sagamihara Hospital, Sagamihara, Kanagawa, Japan2Department of Clinical Laboratory, National Hospital Organization Sagamihara Hospital, Sagamihara, Kanagawa, Japan3Department of Radiology, National Hospital Organization Sagamihara Hospital, Sagamihara, Kanagawa, Japan4Division of Rheumatology, Department of Internal Medicine, Tokai University School of Medicine, Isehara, Kanagawa, Japan1Department of Rheumatology, National Hospital Organization Sagamihara Hospital, Sagamihara, Kanagawa, JapanEarly diagnosis and initiation of treatment in Takayasu arteritis (TA) is important to prevent irreversible arterial changes. A 39-year-old female was diagnosed with active TA. Subcutaneous administration of tocilizumab (162 mg/week) was initiated in combination with prednisolone (30 mg/d). After 21 months, the carotid arterial stenosis and wall thickness had normalized with only slight plaque on echocardiography. After 23 months, computed tomography showed normalization of the overall aortic stenosis and wall thickness. The prednisolone dosage could be reduced to 2 mg/d without relapse for >2 years. Early combination treatment of TA with tocilizumab prevented and normalized vascular stenosis and wall thickness.https://www.acpjournals.org/doi/10.7326/aimcc.2022.0705 |
| spellingShingle | Shinichi Nogi Yusuke Yano Kako Kodama Hirotaka Tsuno Hideki Ogihara Masahiro Kawakami Tomoko Ohmori Shinji Sato Toshihiro Matsui Reversible Improvement of Arterial Stenosis and Wall Thickness in Takayasu Arteritis Through Treatment With Tocilizumab Annals of Internal Medicine: Clinical Cases |
| title | Reversible Improvement of Arterial Stenosis and Wall Thickness in Takayasu Arteritis Through Treatment With Tocilizumab |
| title_full | Reversible Improvement of Arterial Stenosis and Wall Thickness in Takayasu Arteritis Through Treatment With Tocilizumab |
| title_fullStr | Reversible Improvement of Arterial Stenosis and Wall Thickness in Takayasu Arteritis Through Treatment With Tocilizumab |
| title_full_unstemmed | Reversible Improvement of Arterial Stenosis and Wall Thickness in Takayasu Arteritis Through Treatment With Tocilizumab |
| title_short | Reversible Improvement of Arterial Stenosis and Wall Thickness in Takayasu Arteritis Through Treatment With Tocilizumab |
| title_sort | reversible improvement of arterial stenosis and wall thickness in takayasu arteritis through treatment with tocilizumab |
| url | https://www.acpjournals.org/doi/10.7326/aimcc.2022.0705 |
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